144 research outputs found

    Using neurobiological measures to predict and assess trauma-focused psychotherapy outcome in youth with posttraumatic stress disorder

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    In this thesis we examined different predictive neurobiological measures of traumafocused psychotherapy response and investigated the biological mechanisms underlying trauma-focused psychotherapy response in youth with PTSD. Our results suggest that activity of the major neuroendocrine stress response systems and brain functional connectivity before treatment are indeed associated with trauma-focused treatment response. Moreover, trauma-focused psychotherapy response seems to be related to longitudinal changes in autonomic nervous system activity during stress and brain structure. Together, these findings improve our understanding of the relationship between neurobiological measures and traumafocused psychotherapy response in youth with PTSD. However, these insights have currently limited to no clinical value because the current state of evidence does not support implementation of neurobiological biomarkers for treatment selection and necessary trials of (augmentation) treatments targeting neurobiological mechanisms related to treatment response have not been performed yet. The way forward now, is to perform individual prediction studies in less heterogeneous patient samples and to perform developmentally informed long-term studies examining (neuro) developmental trajectories related to PTSD and treatment response. These studies are necessary to address whether neurobiological measures can eventually improve treatment outcome and reduce the burden of PTSD in affected youth

    Advances and Applications of DSmT for Information Fusion. Collected Works, Volume 5

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    This fifth volume on Advances and Applications of DSmT for Information Fusion collects theoretical and applied contributions of researchers working in different fields of applications and in mathematics, and is available in open-access. The collected contributions of this volume have either been published or presented after disseminating the fourth volume in 2015 in international conferences, seminars, workshops and journals, or they are new. The contributions of each part of this volume are chronologically ordered. First Part of this book presents some theoretical advances on DSmT, dealing mainly with modified Proportional Conflict Redistribution Rules (PCR) of combination with degree of intersection, coarsening techniques, interval calculus for PCR thanks to set inversion via interval analysis (SIVIA), rough set classifiers, canonical decomposition of dichotomous belief functions, fast PCR fusion, fast inter-criteria analysis with PCR, and improved PCR5 and PCR6 rules preserving the (quasi-)neutrality of (quasi-)vacuous belief assignment in the fusion of sources of evidence with their Matlab codes. Because more applications of DSmT have emerged in the past years since the apparition of the fourth book of DSmT in 2015, the second part of this volume is about selected applications of DSmT mainly in building change detection, object recognition, quality of data association in tracking, perception in robotics, risk assessment for torrent protection and multi-criteria decision-making, multi-modal image fusion, coarsening techniques, recommender system, levee characterization and assessment, human heading perception, trust assessment, robotics, biometrics, failure detection, GPS systems, inter-criteria analysis, group decision, human activity recognition, storm prediction, data association for autonomous vehicles, identification of maritime vessels, fusion of support vector machines (SVM), Silx-Furtif RUST code library for information fusion including PCR rules, and network for ship classification. Finally, the third part presents interesting contributions related to belief functions in general published or presented along the years since 2015. These contributions are related with decision-making under uncertainty, belief approximations, probability transformations, new distances between belief functions, non-classical multi-criteria decision-making problems with belief functions, generalization of Bayes theorem, image processing, data association, entropy and cross-entropy measures, fuzzy evidence numbers, negator of belief mass, human activity recognition, information fusion for breast cancer therapy, imbalanced data classification, and hybrid techniques mixing deep learning with belief functions as well

    Orvosképzés 2023

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    Analysis of Cellular and Subcellular Morphology using Machine Learning in Microscopy Images

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    Human cells undergo various morphological changes due to progression in the cell-cycle or environmental factors. Classification of these morphological states is vital for effective clinical decisions. Automated classification systems based on machine learning models are data-driven and efficient and help to avoid subjective outcomes. However, the efficacy of these models is highly dependent on the feature description along with the amount and nature of the training data. This thesis presents three studies of automated image-based classification of cellular and subcellular morphologies. The first study presents 3D Sorted Random Projections (SRP) which includes the proposed approach to compute 3D plane information for texture description of 3D nuclear images. The proposed 3D SRP is used to classify nuclear morphology and measure changes in heterochromatin, which in turn helps to characterise cellular states. Classification performance evaluated on 3D images of the human fibroblast and prostate cancer cell lines shows that 3D SRP provides better classification than other feature descriptors. The second study is on imbalanced multiclass and single-label classification of blood cell images. The scarcity of minority sam ples causes a drop in classification performance on minority classes. This study proposes oversampling of minority samples us ing data augmentation approaches, namely mixup, WGAN-div and novel nonlinear mixup, along with a minority class focussed sampling strategy. Classification performance evaluated using F1-score shows that the proposed deep learning framework out performs state-of-the art approaches on publicly available images of human T-lymphocyte cells and red blood cells. The third study is on protein subcellular localisation, which is an imbalanced multiclass and multilabel classification problem. In order to handle data imbalance, this study proposes an oversampling method which includes synthetic images constructed using nonlinear mixup and geometric/colour transformations. The regularisation capability of nonlinear mixup is further improved for protein images. In addition, an imbalance aware sampling strategy is proposed to identify minority and medium classes in the dataset and include them during training. Classification performance evaluated on the Human Protein Atlas Kaggle challenge dataset using F1-score shows that the proposed deep learning framework achieves better predictions than existing methods

    Deep learning applied to computational mechanics: A comprehensive review, state of the art, and the classics

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    Three recent breakthroughs due to AI in arts and science serve as motivation: An award winning digital image, protein folding, fast matrix multiplication. Many recent developments in artificial neural networks, particularly deep learning (DL), applied and relevant to computational mechanics (solid, fluids, finite-element technology) are reviewed in detail. Both hybrid and pure machine learning (ML) methods are discussed. Hybrid methods combine traditional PDE discretizations with ML methods either (1) to help model complex nonlinear constitutive relations, (2) to nonlinearly reduce the model order for efficient simulation (turbulence), or (3) to accelerate the simulation by predicting certain components in the traditional integration methods. Here, methods (1) and (2) relied on Long-Short-Term Memory (LSTM) architecture, with method (3) relying on convolutional neural networks. Pure ML methods to solve (nonlinear) PDEs are represented by Physics-Informed Neural network (PINN) methods, which could be combined with attention mechanism to address discontinuous solutions. Both LSTM and attention architectures, together with modern and generalized classic optimizers to include stochasticity for DL networks, are extensively reviewed. Kernel machines, including Gaussian processes, are provided to sufficient depth for more advanced works such as shallow networks with infinite width. Not only addressing experts, readers are assumed familiar with computational mechanics, but not with DL, whose concepts and applications are built up from the basics, aiming at bringing first-time learners quickly to the forefront of research. History and limitations of AI are recounted and discussed, with particular attention at pointing out misstatements or misconceptions of the classics, even in well-known references. Positioning and pointing control of a large-deformable beam is given as an example.Comment: 275 pages, 158 figures. Appeared online on 2023.03.01 at CMES-Computer Modeling in Engineering & Science

    Predictive and prescriptive modeling for the clinical management of dengue: a case study in Colombia

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    En esta investigación, abordamos el problema del manejo clínico del dengue, que se compone del diagnóstico y el tratamiento de la enfermedad. El dengue es una enfermedad tropical transmitida por vectores que está ampliamente distribuida en todo el mundo. El desarrollo de enfoques que ayuden a la toma de decisiones en enfermedades de interés para la salud pública –como el dengue– es necesario para reducir las tasas de morbilidad y mortalidad. A pesar de la existencia de guías para el manejo clínico, el diagnóstico y el tratamiento del dengue siguen siendo un reto. Para abordar este problema, nuestro objetivo fue desarrollar metodologías, modelos y enfoques para apoyar la toma de decisiones en relación con el manejo clínico de esta infección. Nosotros desarrollamos varios artículos de investigación para cumplir los objetivos propuestos de esta tesis. El primer articulo revisó las últimas tendencias del modelamiento de dengue usando técnicas de aprendizaje automático. El segundo artículo propuso un sistema de apoyo a la decisión para el diagnóstico del dengue utilizando mapas cognitivos difusos. El tercer artículo propuso un ciclo autónomo de tareas de análisis de datos para apoyar tanto el diagnóstico como el tratamiento de la enfermedad. El cuarto artículo presentó una metodología basada en mapas cognitivos difusos y algoritmos de optimización para generar modelos prescriptivos en entornos clínicos. El quinto artículo puso a prueba la metodología anteriormente mencionada en otros dominios de la ciencia como, por ejemplo, los negocios y la educación. Finalmente, el último artículo propuso tres enfoques de aprendizaje federado para garantizar la seguridad y privacidad de los datos relacionados con el manejo clínico del dengue. En cada artículo evaluamos dichas estrategias utilizando diversos conjuntos de datos con signos, síntomas, pruebas de laboratorio e información relacionada con el tratamiento de la enfermedad. Los resultados mostraron la capacidad de las metodologías y modelos desarrollados para predecir la enfermedad, clasificar a los pacientes según su severidad, evaluar el comportamiento de las variables relacionadas con la severidad y recomendar tratamientos basados en las directrices de la Organización Mundial de la Salud.In this research, we address the problem of clinical management of dengue, which is composed of diagnosis and treatment of the disease. Dengue is a vector-borne tropical disease that is widely distributed worldwide. The development of approaches to aid in decision-making for diseases of public health concern –such as dengue– are necessary to reduce morbidity and mortality rates. Despite the existence of clinical management guidelines, the diagnosis and treatment of dengue remains a challenge. To address this problem, our objective was to develop methodologies, models, and approaches to support decision-making regarding the clinical management of this infection. We developed several research articles to meet the proposed objectives of this thesis. The first article reviewed the latest trends in dengue modeling using machine learning (ML) techniques. The second article proposed a decision support system for the diagnosis of dengue using fuzzy cognitive maps (FCMs). The third article proposed an autonomous cycle of data analysis tasks to support both diagnosis and treatment of the disease. The fourth article presented a methodology based on FCMs and optimization algorithms to generate prescriptive models in clinical settings. The fifth article tested the previously mentioned methodology in other science domains such as, business and education. Finally, the last article proposed three federated learning approaches to guarantee the security and privacy of data related to the clinical management of dengue. In each article, we evaluated such strategies using diverse datasets with signs, symptoms, laboratory tests, and information related to the treatment of the disease. The results showed the ability of the developed methodologies and models to predict disease, classify patients according to severity, evaluate the behavior of severity-related variables, and recommend treatments based on World Health Organization (WHO) guidelines

    Smart models to improve agrometeorological estimations and predictions

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    La población mundial, en continuo crecimiento, alcanzará de forma estimada los 9,7 mil millones de habitantes en el 2050. Este incremento, combinado con el aumento en los estándares de vida y la situación de emergencia climática (aumento de la temperatura, intensificación del ciclo del agua, etc.) nos enfrentan al enorme desafío de gestionar de forma sostenible los cada vez más escasos recursos disponibles. El sector agrícola tiene que afrontar retos tan importantes como la mejora en la gestión de los recursos naturales, la reducción de la degradación medioambiental o la seguridad alimentaria y nutricional. Todo ello condicionado por la escasez de agua y las condiciones de aridez: factores limitantes en la producción de cultivos. Para garantizar una producción agrícola sostenible bajo estas condiciones, es necesario que todas las decisiones que se tomen estén basadas en el conocimiento, la innovación y la digitalización de la agricultura de forma que se garantice la resiliencia de los agroecosistemas, especialmente en entornos áridos, semi-áridos y secos sub-húmedos en los que el déficit de agua es estructural. Por todo esto, el presente trabajo se centra en la mejora de la precisión de los actuales modelos agrometeorológicos, aplicando técnicas de inteligencia artificial. Estos modelos pueden proporcionar estimaciones y predicciones precisas de variables clave como la precipitación, la radiación solar y la evapotranspiración de referencia. A partir de ellas, es posible favorecer estrategias agrícolas más sostenibles, gracias a la posibilidad de reducir el consumo de agua y energía, por ejemplo. Además, se han reducido el número de mediciones requeridas como parámetros de entrada para estos modelos, haciéndolos más accesibles y aplicables en áreas rurales y países en desarrollo que no pueden permitirse el alto costo de la instalación, calibración y mantenimiento de estaciones meteorológicas automáticas completas. Este enfoque puede ayudar a proporcionar información valiosa a los técnicos, agricultores, gestores y responsables políticos de la planificación hídrica y agraria en zonas clave. Esta tesis doctoral ha desarrollado y validado nuevas metodologías basadas en inteligencia artificial que han ser vido para mejorar la precision de variables cruciales en al ámbito agrometeorológico: precipitación, radiación solar y evapotranspiración de referencia. En particular, se han modelado sistemas de predicción y rellenado de huecos de precipitación a diferentes escalas utilizando redes neuronales. También se han desarrollado modelos de estimación de radiación solar utilizando exclusivamente parámetros térmicos y validados en zonas con características climáticas similares a lugar de entrenamiento, sin necesidad de estar geográficamente en la misma región o país. Analógamente, se han desarrollado modelos de estimación y predicción de evapotranspiración de referencia a nivel local y regional utilizando también solamente datos de temperatura para todo el proceso: regionalización, entrenamiento y validación. Y finalmente, se ha creado una librería de Python de código abierto a nivel internacional (AgroML) que facilita el proceso de desarrollo y aplicación de modelos de inteligencia artificial, no solo enfocadas al sector agrometeorológico, sino también a cualquier modelo supervisado que mejore la toma de decisiones en otras áreas de interés.The world population, which is constantly growing, is estimated to reach 9.7 billion people in 2050. This increase, combined with the rise in living standards and the climate emergency situation (increase in temperature, intensification of the water cycle, etc.), presents us with the enormous challenge of managing increasingly scarce resources in a sustainable way. The agricultural sector must face important challenges such as improving natural resource management, reducing environmental degradation, and ensuring food and nutritional security. All of this is conditioned by water scarcity and aridity, limiting factors in crop production. To guarantee sustainable agricultural production under these conditions, it is necessary to based all the decision made on knowledge, innovation, and the digitization of agriculture to ensure the resilience of agroecosystems, especially in arid, semi-arid, and sub-humid dry environments where water deficit is structural. Therefore, this work focuses on improving the precision of current agrometeorological models by applying artificial intelligence techniques. These models can provide accurate estimates and predictions of key variables such as precipitation, solar radiation, and reference evapotranspiration. This way, it is possible to promote more sustainable agricultural strategies by reducing water and energy consumption, for example. In addition, the number of measurements required as input parameters for these models has been reduced, making them more accessible and applicable in rural areas and developing countries that cannot afford the high cost of installing, calibrating, and maintaining complete automatic weather stations. This approach can help provide valuable information to technicians, farmers, managers, and policy makers in key wáter and agricultural planning areas. This doctoral thesis has developed and validated new methodologies based on artificial intelligence that have been used to improve the precision of crucial variables in the agrometeorological field: precipitation, solar radiation, and reference evapotranspiration. Specifically, prediction systems and gap-filling models for precipitation at different scales have been modeled using neural networks. Models for estimating solar radiation using only thermal parameters have also been developed and validated in areas with similar climatic characteristics to the training location, without the need to be geographically in the same region or country. Similarly, models for estimating and predicting reference evapotranspiration at the local and regional level have been developed using only temperature data for the entire process: regionalization, training, and validation. Finally, an internationally open-source Python library (AgroML) has been created to facilitate the development and application of artificial intelligence models, not only focused on the agrometeorological sector but also on any supervised model that improves decision-making in other areas of interest

    Modelling, Monitoring, Control and Optimization for Complex Industrial Processes

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    This reprint includes 22 research papers and an editorial, collected from the Special Issue "Modelling, Monitoring, Control and Optimization for Complex Industrial Processes", highlighting recent research advances and emerging research directions in complex industrial processes. This reprint aims to promote the research field and benefit the readers from both academic communities and industrial sectors

    LIPIcs, Volume 277, GIScience 2023, Complete Volume

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    LIPIcs, Volume 277, GIScience 2023, Complete Volum
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