16,486 research outputs found
Fractionally Predictive Spiking Neurons
Recent experimental work has suggested that the neural firing rate can be
interpreted as a fractional derivative, at least when signal variation induces
neural adaptation. Here, we show that the actual neural spike-train itself can
be considered as the fractional derivative, provided that the neural signal is
approximated by a sum of power-law kernels. A simple standard thresholding
spiking neuron suffices to carry out such an approximation, given a suitable
refractory response. Empirically, we find that the online approximation of
signals with a sum of power-law kernels is beneficial for encoding signals with
slowly varying components, like long-memory self-similar signals. For such
signals, the online power-law kernel approximation typically required less than
half the number of spikes for similar SNR as compared to sums of similar but
exponentially decaying kernels. As power-law kernels can be accurately
approximated using sums or cascades of weighted exponentials, we demonstrate
that the corresponding decoding of spike-trains by a receiving neuron allows
for natural and transparent temporal signal filtering by tuning the weights of
the decoding kernel.Comment: 13 pages, 5 figures, in Advances in Neural Information Processing
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Time Resolution Dependence of Information Measures for Spiking Neurons: Atoms, Scaling, and Universality
The mutual information between stimulus and spike-train response is commonly
used to monitor neural coding efficiency, but neuronal computation broadly
conceived requires more refined and targeted information measures of
input-output joint processes. A first step towards that larger goal is to
develop information measures for individual output processes, including
information generation (entropy rate), stored information (statistical
complexity), predictable information (excess entropy), and active information
accumulation (bound information rate). We calculate these for spike trains
generated by a variety of noise-driven integrate-and-fire neurons as a function
of time resolution and for alternating renewal processes. We show that their
time-resolution dependence reveals coarse-grained structural properties of
interspike interval statistics; e.g., -entropy rates that diverge less
quickly than the firing rate indicate interspike interval correlations. We also
find evidence that the excess entropy and regularized statistical complexity of
different types of integrate-and-fire neurons are universal in the
continuous-time limit in the sense that they do not depend on mechanism
details. This suggests a surprising simplicity in the spike trains generated by
these model neurons. Interestingly, neurons with gamma-distributed ISIs and
neurons whose spike trains are alternating renewal processes do not fall into
the same universality class. These results lead to two conclusions. First, the
dependence of information measures on time resolution reveals mechanistic
details about spike train generation. Second, information measures can be used
as model selection tools for analyzing spike train processes.Comment: 20 pages, 6 figures;
http://csc.ucdavis.edu/~cmg/compmech/pubs/trdctim.ht
Sleep-like slow oscillations improve visual classification through synaptic homeostasis and memory association in a thalamo-cortical model
The occurrence of sleep passed through the evolutionary sieve and is
widespread in animal species. Sleep is known to be beneficial to cognitive and
mnemonic tasks, while chronic sleep deprivation is detrimental. Despite the
importance of the phenomenon, a complete understanding of its functions and
underlying mechanisms is still lacking. In this paper, we show interesting
effects of deep-sleep-like slow oscillation activity on a simplified
thalamo-cortical model which is trained to encode, retrieve and classify images
of handwritten digits. During slow oscillations,
spike-timing-dependent-plasticity (STDP) produces a differential homeostatic
process. It is characterized by both a specific unsupervised enhancement of
connections among groups of neurons associated to instances of the same class
(digit) and a simultaneous down-regulation of stronger synapses created by the
training. This hierarchical organization of post-sleep internal representations
favours higher performances in retrieval and classification tasks. The
mechanism is based on the interaction between top-down cortico-thalamic
predictions and bottom-up thalamo-cortical projections during deep-sleep-like
slow oscillations. Indeed, when learned patterns are replayed during sleep,
cortico-thalamo-cortical connections favour the activation of other neurons
coding for similar thalamic inputs, promoting their association. Such mechanism
hints at possible applications to artificial learning systems.Comment: 11 pages, 5 figures, v5 is the final version published on Scientific
Reports journa
Biologically plausible deep learning -- but how far can we go with shallow networks?
Training deep neural networks with the error backpropagation algorithm is
considered implausible from a biological perspective. Numerous recent
publications suggest elaborate models for biologically plausible variants of
deep learning, typically defining success as reaching around 98% test accuracy
on the MNIST data set. Here, we investigate how far we can go on digit (MNIST)
and object (CIFAR10) classification with biologically plausible, local learning
rules in a network with one hidden layer and a single readout layer. The hidden
layer weights are either fixed (random or random Gabor filters) or trained with
unsupervised methods (PCA, ICA or Sparse Coding) that can be implemented by
local learning rules. The readout layer is trained with a supervised, local
learning rule. We first implement these models with rate neurons. This
comparison reveals, first, that unsupervised learning does not lead to better
performance than fixed random projections or Gabor filters for large hidden
layers. Second, networks with localized receptive fields perform significantly
better than networks with all-to-all connectivity and can reach backpropagation
performance on MNIST. We then implement two of the networks - fixed, localized,
random & random Gabor filters in the hidden layer - with spiking leaky
integrate-and-fire neurons and spike timing dependent plasticity to train the
readout layer. These spiking models achieve > 98.2% test accuracy on MNIST,
which is close to the performance of rate networks with one hidden layer
trained with backpropagation. The performance of our shallow network models is
comparable to most current biologically plausible models of deep learning.
Furthermore, our results with a shallow spiking network provide an important
reference and suggest the use of datasets other than MNIST for testing the
performance of future models of biologically plausible deep learning.Comment: 14 pages, 4 figure
Repeating Spatial-Temporal Motifs of CA3 Activity Dependent on Engineered Inputs from Dentate Gyrus Neurons in Live Hippocampal Networks.
Anatomical and behavioral studies, and in vivo and slice electrophysiology of the hippocampus suggest specific functions of the dentate gyrus (DG) and the CA3 subregions, but the underlying activity dynamics and repeatability of information processing remains poorly understood. To approach this problem, we engineered separate living networks of the DG and CA3 neurons that develop connections through 51 tunnels for axonal communication. Growing these networks on top of an electrode array enabled us to determine whether the subregion dynamics were separable and repeatable. We found spontaneous development of polarized propagation of 80% of the activity in the native direction from DG to CA3 and different spike and burst dynamics for these subregions. Spatial-temporal differences emerged when the relationships of target CA3 activity were categorized with to the number and timing of inputs from the apposing network. Compared to times of CA3 activity when there was no recorded tunnel input, DG input led to CA3 activity bursts that were 7Ă— more frequent, increased in amplitude and extended in temporal envelope. Logistic regression indicated that a high number of tunnel inputs predict CA3 activity with 90% sensitivity and 70% specificity. Compared to no tunnel input, patterns of >80% tunnel inputs from DG specified different patterns of first-to-fire neurons in the CA3 target well. Clustering dendrograms revealed repeating motifs of three or more patterns at up to 17 sites in CA3 that were importantly associated with specific spatial-temporal patterns of tunnel activity. The number of these motifs recorded in 3 min was significantly higher than shuffled spike activity and not seen above chance in control networks in which CA3 was apposed to CA3 or DG to DG. Together, these results demonstrate spontaneous input-dependent repeatable coding of distributed activity in CA3 networks driven by engineered inputs from DG networks. These functional configurations at measured times of activation (motifs) emerge from anatomically accurate feed-forward connections from DG through tunnels to CA3
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