Bridging spatiotemporal scales in biomechanical models for living tissues : from the contracting Esophagus to cardiac growth

Appropriate functioning of our body is determined by the mechanical behavior of our organs. An improved understanding of the biomechanical functioning of the soft tissues making up these organs is therefore crucial for the choice for, and development of, efficient clinical treatment strategies focused on patient-specific pathophysiology. This doctoral dissertation describes the passive and active biomechanical behavior of gastrointestinal and cardiovascular tissue, both in the short and long term, through computer models that bridge the cell, tissue and organ scale. Using histological characterization, mechanical testing and medical imaging techniques, virtual esophagus and heart models are developed that simulate the patient-specific biomechanical organ behavior as accurately as possible. In addition to the diagnostic value of these models, the developed modeling technology also allows us to predict the acute and chronic effect of various treatment techniques, through e.g. drugs, surgery and/or medical equipment. Consequently, this dissertation offers insights that will have an unmistakable impact on the personalized medicine of the future.Het correct functioneren van ons lichaam wordt bepaald door het mechanisch gedrag van onze organen. Een verbeterd inzicht in het biomechanisch functioneren van deze zachte weefsels is daarom van cruciale waarde voor de keuze voor, en ontwikkeling van, efficiënte klinische behandelingsstrategieën gefocust op de patiënt-specifieke pathofysiologie. Deze doctoraatsthesis brengt het passieve en actieve biomechanisch gedrag van gastro-intestinaal en cardiovasculair weefsel, zowel op korte als lange termijn, in kaart via computermodellen die een brug vormen tussen cel-, weefsel- en orgaanniveau. Aan de hand van histologische karakterisering, mechanische testen en medische beeldvormingstechnieken worden virtuele slokdarm- en hartmodellen ontwikkeld die het patiënt-specifieke orgaangedrag zo accuraat mogelijk simuleren. Naast de diagnostische waarde van deze modellen, laat de ontwikkelde modelleringstechnologie ook toe om het effect van verschillende behandelingstechnieken, via medicatie, chirurgie en/of medische apparatuur bijvoorbeeld, acuut en chronisch te voorspellen. Bijgevolg biedt deze doctoraatsthesis inzichten die een onmiskenbare impact zullen hebben op de gepersonaliseerde geneeskunde van de toekomst

Stenting as porous media in anatomically accurate geometries: A comparison of models and spatial heterogeneity

Modelling intracranial aneurysm blood flow after flow diverter treatment has proven to be of great scientific and clinical interest. One of the reasons for not having CFD as an everyday clinical tool yet is the time required to set-up such simulations plus the required computational time. The speed-up of these simulations can have a considerable impact during treatment planning and device selection. Modelling flow diverters as a porous medium (PM) can considerably improve the computational time. Many models have been presented in literature, but quantitative comparisons between models are scarce.In this study, the untreated case, the explicit definition of the flow diverter wires as no-slip boundary condition and five different porous medium models were chosen for comparison, and evaluated on intracranial aneurysm of 14 patients with different shapes, sizes, and locations. CFD simulations were made using finite volume method on steady flow conditions. Velocities, kinetic energy, wall shear stress, and computational time were assessed for each model. Then, all models are compared against the no-slip boundary condition using non parametric Kolmogorov–Smirnov test.The model with least performance showed a mean K-S statistic of 0.31 and deviance of 0.2, while the model with best values always gave K-S statistics below 0.2. Kinetic energy between PM models varied between an over estimation of 218.3% and an under estimation of 73.06%. Also, speedups were between 4.75x and 5.3x (stdev: 0.38x and 0.15x) when using PM models.Flow diverters can be simulated with PM with a good agreement to standard CFD simulations were FD wires are represented with no-slip boundary condition in less than a quarter of the time. Best results were obtained on PM models based on geometrical properties, in particular, when using a heterogeneous medium based on equations for flat rhomboidal wire frames.Fil: Dazeo, Nicolás Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; ArgentinaFil: Dottori, Javier Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; ArgentinaFil: Boroni, Gustavo Adolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; ArgentinaFil: Narata, Ana Paula. Universite de Tours; FranciaFil: Larrabide, Ignacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Exactas. Grupo de Plasmas Densos Magnetizados. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Grupo de Plasmas Densos Magnetizados; Argentin

Assessment of landslide susceptibility in Structurally Complex Formations by integration of different A-DInSAR techniques

Instability events are recurring phenomena in Southern Italy due to its geological history and tectonic-geomorphological evolution leading to the occurrence of several formations identified as Structurally Complex Formations (SCFs; Esu, 1977) in a territory mainly composed of densely populated areas also in mountainous and hilly regions. SCFs are clay-dominant terrains that, usually, give origin from very-slow to extremely-slow phenomena (Cruden and Varnes, 1996) with a long evolutionary history made up of multiple reactivations that makes difficult their identification, monitoring and susceptibility evaluation. The study has been carried out from point-wise (Bisaccia, Costa della Gaveta and Nerano cases) to wide areas (Palermo province case) where crops out SCFs as the Termini sandstones Formation (CARG, 2011), the Varicoloured Clays of Calaggio Formation (Ciaranfi et al., 1973), the Varicoloured Clays Unit (Mattioni et al., 2006) the Sicilide Unit (Vitale and Ciarcia, 2013 and references therein), the Numidian Flysch (Johansson et al., 1998) and the Corleone Calcarenites (Catalano R. et al., 2002). The aim of this thesis is to produce updated Landslide Inventory Maps and, whenever possible, Landslide Susceptibility Maps following a new approach during the landslide mapping and landslide monitoring stages. The Landslide Inventory Maps have taken into account the combination of geological, geomorphological, and stereoscopic surveys, as well as engineering geological investigations, namely conventional techniques. In addition innovative Advanced-Differential Interferometry Synthetic Aperture Radar (A-DInSAR) techniques have been used: the Coherent Pixels Technique – CPT (Mora et al., 2003; Blanco et al., 2008), the Intermittent Small BAseline Subset – ISBAS (Sowter et al., 2013) and the Ground-Based Synthetic Aperture Radar. Finally, the Weight of Evidence method (van Westen, 1993) has been chosen to generate the Landslide Susceptibility Maps only for the point-wise studies. In the case of Nerano (Province of Naples), the ISBAS analysis on ENVISAT images (for the period 2003-2010) has been carried out and compared with inclinometric and rainfall data. These have revealed several reactivations of a rotational slide + earth flow (Cruden and Varnes, 1996) that involves reworked clay olistostromes and limestone olistoliths inside the Termini sandstones Formation; even in recent years the landslide, despite many engineering works, has given evidence of a continuing activity. The results highlight a very slow movement in the detachment zone (<1 mm/yr), which assumes slightly higher values in the accumulation area (5 mm/yr). The Landslide Susceptibility Map confirms the high levels in the flow track and the accumulation area. In Bisaccia (Province of Avellino), a conglomeratic slab undergoes a Deep Seated Gravitational Slope Deformation (DSGSD; Pasuto and Soldati, 2013 and references therein) due to the bedrock consolidation, made of the Varicoloured Clays of Calaggio Formation. Here the CPT processing on ENVISAT images (covering the period between 2002 and 2010), displays a vertical displacement for the town center, suffering a progressively increasing velocity from the southern (4.2 mm/yr) to the northern (15.5 mm/yr) portion of the slab that localizes four different sectors. The pattern is confirmed from the building damage map. The landslides susceptibility reaches the highest values in the adjacent valleys and at the edges of each sector. Multiple datasets have been employed for the Costa della Gaveta case-study (Province of Potenza), these encompass: ENVISAT, TerraSAR-X and COSMO-SkyMed constellations together with Ground Based Synthetic Aperture Radar (GBSAR). The A-DInSAR data have been compared with stereoscopic analysis and the available rainfall and inclinometric data. The analysis allows for the identification of 16 landslides (complexes and earth flows; Cruden and Varnes, 1996) developed in the Varicoloured Clays Unit that show, according to all the existing instruments, velocities between 1.5 and 30 mm/yr. The western side of Costa della Gaveta slope is the portion which suffers the highest landslides susceptibility levels. In the Province of Palermo (northwestern Sicily) information deriving from A-DInSAR processing, specifically the ISBAS technique, have been focused on three subareas (Piana degli Albanesi, Marineo and Ventimiglia di Sicilia) for a total extension of 182 Km2 where standard A-DInSAR algorithms showed limitations due to the widespread presence of densely vegetated areas. The radar-detected landslides have been validated through field geomorphological mapping and stereoscopic analysis proving to be highly consistent especially with slow phenomena. The outcome has allowed to confirm 152 preexisting landslides, to detect 81 new events and to change 133 previously mapped landslides, modifying their typology, boundary and/or state of activity. The study demonstrates how a better knowledge of landslide development and their cause-effect mechanisms provided by new Earth Observation techniques is useful for Landslide Inventory and Susceptibility Maps. The research project has been carried out at the University of Naples "Federico II", including nine months (September 2013 – May 2014) spent in the United Kingdom, at the British Geological Survey under the supervision of Dr. Francesca Cigna and Dr. Jordan Colm and at the University of Nottingham (Department of Civil Engineering), under the supervision of Dr. Andrew Sowter where the ISBAS technique has been recently developed