Teleoperation of MRI-Compatible Robots with Hybrid Actuation and Haptic Feedback

Image guided surgery (IGS), which has been developing fast recently, benefits significantly from the superior accuracy of robots and magnetic resonance imaging (MRI) which is a great soft tissue imaging modality. Teleoperation is especially desired in the MRI because of the highly constrained space inside the closed-bore MRI and the lack of haptic feedback with the fully autonomous robotic systems. It also very well maintains the human in the loop that significantly enhances safety. This dissertation describes the development of teleoperation approaches and implementation on an example system for MRI with details of different key components. The dissertation firstly describes the general teleoperation architecture with modular software and hardware components. The MRI-compatible robot controller, driving technology as well as the robot navigation and control software are introduced. As a crucial step to determine the robot location inside the MRI, two methods of registration and tracking are discussed. The first method utilizes the existing Z shaped fiducial frame design but with a newly developed multi-image registration method which has higher accuracy with a smaller fiducial frame. The second method is a new fiducial design with a cylindrical shaped frame which is especially suitable for registration and tracking for needles. Alongside, a single-image based algorithm is developed to not only reach higher accuracy but also run faster. In addition, performance enhanced fiducial frame is also studied by integrating self-resonant coils. A surgical master-slave teleoperation system for the application of percutaneous interventional procedures under continuous MRI guidance is presented. The slave robot is a piezoelectric-actuated needle insertion robot with fiber optic force sensor integrated. The master robot is a pneumatic-driven haptic device which not only controls the position of the slave robot, but also renders the force associated with needle placement interventions to the surgeon. Both of master and slave robots mechanical design, kinematics, force sensing and feedback technologies are discussed. Force and position tracking results of the master-slave robot are demonstrated to validate the tracking performance of the integrated system. MRI compatibility is evaluated extensively. Teleoperated needle steering is also demonstrated under live MR imaging. A control system of a clinical grade MRI-compatible parallel 4-DOF surgical manipulator for minimally invasive in-bore prostate percutaneous interventions through the patient’s perineum is discussed in the end. The proposed manipulator takes advantage of four sliders actuated by piezoelectric motors and incremental rotary encoders, which are compatible with the MRI environment. Two generations of optical limit switches are designed to provide better safety features for real clinical use. The performance of both generations of the limit switch is tested. MRI guided accuracy and MRI-compatibility of whole robotic system is also evaluated. Two clinical prostate biopsy cases have been conducted with this assistive robot

SCADA and related technologies for irrigation district modernization

Presented at SCADA and related technologies for irrigation district modernization: a USCID water management conference on October 26-29, 2005 in Vancouver, Washington.Includes bibliographical references.Overview of Supervisory Control and Data Acquisition (SCADA) -- Total Channel Control™ - The value of automation in irrigation distribution systems -- Design and implementation of an irrigation canal SCADA -- All American Canal Monitoring Project -- Taking closed piping flowmeters to the next level - new technologies support trends in data logging and SCADA systems -- Real-time model-based dam automation: a case study of the Piute Dam -- Effective implementation of algorithm theory into PLCs -- Optimal fuzzy control for canal control structures -- SCADA over Zigbee™ -- Synchronous radio modem technology for affordable irrigation SCADA systems -- A suggested criteria for the selection of RTUs and sensors -- Irrigation canals in Spain: the integral process of modernization -- Ten years of SCADA data quality control and utilization for system management and planning modernization -- Moderately priced SCADA implementation -- Increasing peak power generation using SCADA and automation: a case study of the Kaweah River Power Authority -- Eastern Irrigation District canal automation and Supervisory Control and Data Acquisition (SCADA) -- Case study on design and construction of a regulating reservoir pumping station -- Saving water with Total Channel Control® in the Macalister Irrigation District, Australia -- Leveraging SCADA to modernize operations in the Klamath Irrigation Project -- A 2005 update on the installation of a VFD/SCADA system at Sutter Mutual Water Company -- Truckee Carson Irrigation District Turnout Water Measurement Program -- The myth of a "Turnkey" SCADA system and other lessons learned -- Canal modernization in Central California Irrigation District - case study -- Remote monitoring and operation at the Colorado River Irrigation District -- Web-based GIS decision support system for irrigation districts -- Using RiverWare as a real time river systems management tool -- Submerged venturi flume -- Ochoco Irrigation District telemetry case study -- Uinta Basin Replacement Project: a SCADA case study in managing multiple interests and adapting to loss of storage -- Training SCADA operators with real-time simulation -- Demonstration of gate control with SCADA system in Lower Rio Grande Valley, in Texas -- Incorporating sharp-crested weirs into irrigation SCADA systems

Development of a Multi-Objective Optimization Capability for Heterogeneous Light Water Reactor Fuel Assemblies

As pressure grows on developed nations to move away from fossil fuel-based energy sources, so does the potential for nuclear energy to make its resurgence. However, the complex nature of the design process in nuclear engineering and a regulatory culture of ever-increasing safety standards create unique challenges to the nuclear industry. As in many engineering disciplines, the question is one of trade-offs between safety, performance, cost, and time required to develop the design from paper to real life operation. The possibilities facing a designer are virtually unlimited, with fuel choice, layout and operating conditions just three of the many categories which interact with one another in a highly non-linear manner, making it difficult to quantitatively define these trade-offs. Deciding upon an ‘optimal’ design is therefore traditionally done through expert judgement and an iterative design process. Mathematical optimization methods offer a more formal way to optimize designs by employing algorithms to explore the myriad of possibilities in a methodical manner which can yield increased performance over expert designs. In this thesis, an extensive review of the literature revealed gaps which present opportunities for novel research. Two new algorithms are created with the ability to solve optimization problems with multiple objectives simultaneously without requiring weighting or bias from the designer. They are then applied to a series of problems drawn from both the literature and real world designs. The results demonstrate the algorithms’ effectiveness and robustness as well as their ability to handle complex multi-physics problems with reasonably low computational requirements. This research offers an original and effective tool for performing optimization on nuclear fuel assembly design problems and has advanced the state of the art in both multi-objective optimization and its application to the nuclear engineering industry

Cost-Effective, Commercial Scale Production of Tanespimycin

Recent approaches to cancer therapy have centered on developing small molecule inhibitors for signaling pathways deranged in common cancers; these compounds are sometimes referred to as tumor antibiotics. One promising target for tumor antibiotics is Hsp90, a heat shock protein that plays a central role in promoting the functionality and stability of a group of proteins associated with cancer called client proteins. Hsp90 inhibitors have been receiving extensive research attention, with geldanamycin, tanespimycin, and their derivatives at the forefront. This report describes a novel, cost-effective, commercial scale process design for the production of tanespimycin. The proposed production facility is designed to deliver 1,084 kg/year through 55 batches, requiring operation of 293 days/year. Detailed economic analysis suggest the recuperation of funds after an initial investment into the biopharmaceutical plant and Phase III trials, which suggest that further investment in this process design would be highly profitable

Design of low complexity fault tolerance for life critical situation awareness systems

In cyber-human-medical environments, coordinating supervisory medical systems and medical staff to perform treatment in accordance with best practice is essential for patient safety. However, the dynamics of patient conditions and the non-deterministic nature of potential side effects of treatment pose significant challenges. This work covers my contribution to one such system in development of its low complexity workflow which enhances situation awareness and in the design and implementation of it fault tolerance. In the first part of this document, we cover a validation protocol to enforce the correct execution sequence of treatments, preconditions validation, side effects monitoring and checking expected responses based on patho-physiological models. The proposed protocol organizes the medical information concisely and comprehensively to help medical staff validate treatments.The proposed protocol dynamically adapts to the patient conditions and side effects of treatments. A cardiac arrest scenario is used as a case study to verify the safety properties of the proposed protocol. In the second part of this document, we describe the integration of some well understood fault tolerance strategies in context of safety critical systems. We list out the requirements of our system and explore the traditional Active/Standby in context of certain guiding design principles to fit our specific requirement. Like any software engineering project, we design test suites to ensure QOS. We go a step further and try to make this design verifiable using model checking tools like UPPAAL to demonstrate the correctness of our system architecture under conditions of normal operation and failure

Health-aware predictive control schemes based on industrial processes

Aplicat embargament des de la data de defensa fins el dia 30 de desembre de 2021The research is motivated by real applications, such as pasteurization plant, water networks and autonomous system, which each of them require a specific control system to provide proper management able to take into account their particular features and operating limits in presence of uncertainties related to their operation and failures from component breakdowns. According to that most of the real systems have nonlinear behaviors, it can be approximated them by polytopic linear uncertain models such as Linear Parameter Varying (LPV) and Takagi-Sugeno (TS) models. Therefore, a new economic Model Predictive Control (MPC) approach based on LPV/TS models is proposed and the stability of the proposed approach is certified by using a region constraint on the terminal state. Besides, the MPC-LPV strategy is extended based on the system with varying delays affecting states and inputs. The control approach allows the controller to accommodate the scheduling parameters and delay change. By computing the prediction of the state variables and delay along a prediction time horizon, the system model can be modified according to the evaluation of the estimated state and delay at each time instant. To increase the system reliability, anticipate the appearance of faults and reduce the operational costs, actuator health monitoring should be considered. Regarding several types of system failures, different strategies are studied for obtaining system failures. First, the damage is assessed with the rainflow-counting algorithm that allows estimating the component’s fatigue and control objective is modified by adding an extra criterion that takes into account the accumulated damage. Besides, two different health-aware economic predictive control strategies that aim to minimize the damage of components are presented. Then, economic health-aware MPC controller is developed to compute the components and system reliability in the MPC model using an LPV modeling approach and maximizes the availability of the system by estimating system reliability. Additionally, another improvement considers chance-constraint programming to compute an optimal list replenishment policy based on a desired risk acceptability level, managing to dynamically designate safety stocks in flowbased networks to satisfy non-stationary flow demands. Finally, an innovative health-aware control approach for autonomous racing vehicles to simultaneously control it to the driving limits and to follow the desired path based on maximization of the battery RUL. The proposed approach is formulated as an optimal on-line robust LMI based MPC driven from Lyapunov stability and controller gain synthesis solved by LPV-LQR problem in LMI formulation with integral action for tracking the trajectory.Esta tesis pretende proporcionar contribuciones teóricas y prácticas sobre seguridad y control de sistemas industriales, especialmente en la forma maten ática de sistemas inciertos. La investigación está motivada por aplicaciones reales, como la planta de pasteurización, las redes de agua y el sistema autónomo, cada uno de los cuales requiere un sistema de control específico para proporcionar una gestión adecuada capaz de tener en cuenta sus características particulares y limites o de operación en presencia de incertidumbres relacionadas con su operación y fallas de averías de componentes. De acuerdo con que la mayoría de los sistemas reales tienen comportamientos no lineales, puede aproximarse a ellos mediante modelos inciertos lineales politopicos como los modelos de Lineal Variación de Parámetros (LPV) y Takagi-Sugeno (TS). Por lo tanto, se propone un nuevo enfoque de Control Predictivo del Modelo (MPC) económico basado en modelos LPV/TS y la estabilidad del enfoque propuesto se certifica mediante el uso de una restricción de región en el estado terminal. Además, la estrategia MPC-LPV se extiende en función del sistema con diferentes demoras que afectan los estados y las entradas. El enfoque de control permite al controlador acomodar los parámetros de programación y retrasar el cambio. Al calcular la predicción de las variables de estado y el retraso a lo largo de un horizonte de tiempo de predicción, el modelo del sistema se puede modificar de acuerdo con la evaluación del estado estimado y el retraso en cada instante de tiempo. Para aumentar la confiabilidad del sistema, anticipar la aparición de fallas y reducir los costos operativos, se debe considerar el monitoreo del estado del actuador. Con respecto a varios tipos de fallas del sistema, se estudian diferentes estrategias para obtener fallas del sistema. Primero, el daño se evalúa con el algoritmo de conteo de flujo de lluvia que permite estimar la fatiga del componente y el objetivo de control se modifica agregando un criterio adicional que tiene en cuenta el daño acumulado. Además, se presentan dos estrategias diferentes de control predictivo económico que tienen en cuenta la salud y tienen como objetivo minimizar el daño de los componentes. Luego, se desarrolla un controlador MPC económico con conciencia de salud para calcular los componentes y la confiabilidad del sistema en el modelo MPC utilizando un enfoque de modelado LPV y maximiza la disponibilidad del sistema mediante la estimación de la confiabilidad del sistema. Además, otra mejora considera la programación de restricción de posibilidades para calcular una política ´optima de reposición de listas basada en un nivel de aceptabilidad de riesgo deseado, logrando designar dinámicamente existencias de seguridad en redes basadas en flujo para satisfacer demandas de flujo no estacionarias. Finalmente, un enfoque innovador de control consciente de la salud para vehículos de carreras autónomos para controlarlo simultáneamente hasta los límites de conducción y seguir el camino deseado basado en la maximización de la bacteria RUL. El diseño del control se divide en dos capas con diferentes escalas de tiempo, planificador de ruta y controlador. El enfoque propuesto está formulado como un MPC robusto en línea optimo basado en LMI impulsado por la estabilidad de Lyapunov y la síntesis de ganancia del controlador resuelta por el problema LPV-LQR en la formulación de LMI con acción integral para el seguimiento de la trayectoria.Postprint (published version

The design and development of an educational controls laboratory : electromagnetic module, control software, and graphical user interface

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1995.Includes bibliographical references (leaves 106-108).by Richard Dick Wang.M.S

NASA Tech Briefs, July 2002

Topics include: a technology focus sensors, software, electronic components and systems, materials, mechanics, machinery/automation, manufacturing, bio-medical, physical sciences, information sciences, book and reports, and a special section of Photonics Tech Briefs