10,858 research outputs found
Predictability of evolutionary trajectories in fitness landscapes
Experimental studies on enzyme evolution show that only a small fraction of
all possible mutation trajectories are accessible to evolution. However, these
experiments deal with individual enzymes and explore a tiny part of the fitness
landscape. We report an exhaustive analysis of fitness landscapes constructed
with an off-lattice model of protein folding where fitness is equated with
robustness to misfolding. This model mimics the essential features of the
interactions between amino acids, is consistent with the key paradigms of
protein folding and reproduces the universal distribution of evolutionary rates
among orthologous proteins. We introduce mean path divergence as a quantitative
measure of the degree to which the starting and ending points determine the
path of evolution in fitness landscapes. Global measures of landscape roughness
are good predictors of path divergence in all studied landscapes: the mean path
divergence is greater in smooth landscapes than in rough ones. The
model-derived and experimental landscapes are significantly smoother than
random landscapes and resemble additive landscapes perturbed with moderate
amounts of noise; thus, these landscapes are substantially robust to mutation.
The model landscapes show a deficit of suboptimal peaks even compared with
noisy additive landscapes with similar overall roughness. We suggest that
smoothness and the substantial deficit of peaks in the fitness landscapes of
protein evolution are fundamental consequences of the physics of protein
folding.Comment: 14 pages, 7 figure
Incremental embodied chaotic exploration of self-organized motor behaviors with proprioceptor adaptation
This paper presents a general and fully dynamic embodied artificial neural system, which incrementally explores and learns motor behaviors through an integrated combination of chaotic search and reflex learning. The former uses adaptive bifurcation to exploit the intrinsic chaotic dynamics arising from neuro-body-environment interactions, while the latter is based around proprioceptor adaptation. The overall iterative search process formed from this combination is shown to have a close relationship to evolutionary methods. The architecture developed here allows realtime goal-directed exploration and learning of the possible motor patterns (e.g., for locomotion) of embodied systems of arbitrary morphology. Examples of its successful application to a simple biomechanical model, a simulated swimming robot, and a simulated quadruped robot are given. The tractability of the biomechanical systems allows detailed analysis of the overall dynamics of the search process. This analysis sheds light on the strong parallels with evolutionary search
Statistical Laws Governing Fluctuations in Word Use from Word Birth to Word Death
We analyze the dynamic properties of 10^7 words recorded in English, Spanish
and Hebrew over the period 1800--2008 in order to gain insight into the
coevolution of language and culture. We report language independent patterns
useful as benchmarks for theoretical models of language evolution. A
significantly decreasing (increasing) trend in the birth (death) rate of words
indicates a recent shift in the selection laws governing word use. For new
words, we observe a peak in the growth-rate fluctuations around 40 years after
introduction, consistent with the typical entry time into standard dictionaries
and the human generational timescale. Pronounced changes in the dynamics of
language during periods of war shows that word correlations, occurring across
time and between words, are largely influenced by coevolutionary social,
technological, and political factors. We quantify cultural memory by analyzing
the long-term correlations in the use of individual words using detrended
fluctuation analysis.Comment: Version 1: 31 pages, 17 figures, 3 tables. Version 2 is streamlined,
eliminates substantial material and incorporates referee comments: 19 pages,
14 figures, 3 table
Virus Replication as a Phenotypic Version of Polynucleotide Evolution
In this paper we revisit and adapt to viral evolution an approach based on
the theory of branching process advanced by Demetrius, Schuster and Sigmund
("Polynucleotide evolution and branching processes", Bull. Math. Biol. 46
(1985) 239-262), in their study of polynucleotide evolution. By taking into
account beneficial effects we obtain a non-trivial multivariate generalization
of their single-type branching process model. Perturbative techniques allows us
to obtain analytical asymptotic expressions for the main global parameters of
the model which lead to the following rigorous results: (i) a new criterion for
"no sure extinction", (ii) a generalization and proof, for this particular
class of models, of the lethal mutagenesis criterion proposed by Bull,
Sanju\'an and Wilke ("Theory of lethal mutagenesis for viruses", J. Virology 18
(2007) 2930-2939), (iii) a new proposal for the notion of relaxation time with
a quantitative prescription for its evaluation, (iv) the quantitative
description of the evolution of the expected values in in four distinct
"stages": extinction threshold, lethal mutagenesis, stationary "equilibrium"
and transient. Finally, based on these quantitative results we are able to draw
some qualitative conclusions.Comment: 23 pages, 1 figure, 2 tables. arXiv admin note: substantial text
overlap with arXiv:1110.336
Evolvability signatures of generative encodings: beyond standard performance benchmarks
Evolutionary robotics is a promising approach to autonomously synthesize
machines with abilities that resemble those of animals, but the field suffers
from a lack of strong foundations. In particular, evolutionary systems are
currently assessed solely by the fitness score their evolved artifacts can
achieve for a specific task, whereas such fitness-based comparisons provide
limited insights about how the same system would evaluate on different tasks,
and its adaptive capabilities to respond to changes in fitness (e.g., from
damages to the machine, or in new situations). To counter these limitations, we
introduce the concept of "evolvability signatures", which picture the
post-mutation statistical distribution of both behavior diversity (how
different are the robot behaviors after a mutation?) and fitness values (how
different is the fitness after a mutation?). We tested the relevance of this
concept by evolving controllers for hexapod robot locomotion using five
different genotype-to-phenotype mappings (direct encoding, generative encoding
of open-loop and closed-loop central pattern generators, generative encoding of
neural networks, and single-unit pattern generators (SUPG)). We observed a
predictive relationship between the evolvability signature of each encoding and
the number of generations required by hexapods to adapt from incurred damages.
Our study also reveals that, across the five investigated encodings, the SUPG
scheme achieved the best evolvability signature, and was always foremost in
recovering an effective gait following robot damages. Overall, our evolvability
signatures neatly complement existing task-performance benchmarks, and pave the
way for stronger foundations for research in evolutionary robotics.Comment: 24 pages with 12 figures in the main text, and 4 supplementary
figures. Accepted at Information Sciences journal (in press). Supplemental
videos are available online at, see http://goo.gl/uyY1R
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