A Prediction Model of Blood Pressure for Telemedicine

This paper presents a new study based on a machine learning technique, specifically an artificial neural network, for predicting systolic blood pressure through the correlation of variables (age, BMI, exercise level, alcohol consumption level, smoking status, stress level, and salt intake level). The study was carried out using a database containing a variety of variables/factors. Each database of raw data was split into two parts: one part for training the neural network and the remaining part for testing the performance of the network. Two neural network algorithms, back-propagation and radial basis function, were used to construct and validate the prediction system. According to the experiment, the accuracy of our predictions of systolic blood pressure values exceeded 90%. Our experimental results show that artificial neural networks are suitable for modeling and predicting systolic blood pressure. This new method of predicting systolic blood pressure helps to give an early warning to adults, who may not get regular blood pressure measurements that their blood pressure might be at an unhealthy level. Also, because an isolated measurement of blood pressure is not always very accurate due to daily fluctuations, our predictor can provide the predicted value as another figure for medical staff to refer to.postprin

A Study on the Correlation Between Hand Grip and Age Using Statistical and Machine Learning Analysis

Handgrip strength (HGS) is an easy-to-use instrument for monitoring people's health status. Numerous researchers in many countries have done a study on handgrip disease or demographic data. This study focused on classifying aged groups referring to handgrip value using machine learning. A total of fifty-four participants had involved in this study, ages ranging from 24 years to 57 years old. Digital Pinch Grip Analyzer had been used to measure the handgrip measurement three times to get more accurate results. The result is then recorded by Clinical Analysis Software (CAS) that is built into the analyzer. An independent t-test is used to investigate the significant factor for age group classification. The data were then classified using machine learning analysis which are Support Vector Machine (SVM), Random Forest (RF), and Naïve Bayes. The overall dataset shows that the Support Vector Machine is the most suitable classification technique with average accuracy between 5 groups of age is 98%, specificity of 0.79, the sensitivity of 0.9814 and 0.0185 of mean absolute error. SVM also give the lowest mean absolute error compared to RF and Naïve Bayes. This study is consistent with the previous work that there is a relationship between handgrip and age

A Study on the Correlation Between Hand Grip and Age Using Statistical and Machine Learning Analysis

Handgrip strength (HGS) is an easy-to-use instrument for monitoring people's health status. Numerous researchers in many countries have done a study on handgrip disease or demographic data. This study focused on classifying aged groups referring to handgrip value using machine learning. A total of fifty-four participants had involved in this study, ages ranging from 24 years to 57 years old. Digital Pinch Grip Analyzer had been used to measure the handgrip measurement three times to get more accurate results. The result is then recorded by Clinical Analysis Software (CAS) that is built into the analyzer. An independent t-test is used to investigate the significant factor for age group classification. The data were then classified using machine learning analysis which are Support Vector Machine (SVM), Random Forest (RF), and Naïve Bayes. The overall dataset shows that the Support Vector Machine is the most suitable classification technique with average accuracy between 5 groups of age is 98%, specificity of 0.79, the sensitivity of 0.9814 and 0.0185 of mean absolute error. SVM also give the lowest mean absolute error compared to RF and Naïve Bayes. This study is consistent with the previous work that there is a relationship between handgrip and age

Towards the interpretability of deep learning models for human neuroimaging

Brain-age (BA) estimates based on deep learning are increasingly used as neuroimaging biomarker for brain health; however, the underlying neural features have remained unclear.We combined ensembles of convolutional neural networks with Layer-wise Relevance Propagation (LRP) to detect which brain features contribute to BA. Trained on magnetic resonance imaging (MRI) data of a population-based study (n=2637, 18-82 years), our models estimated age accurately based on single and multiple modalities, regionally restricted and whole-brain images (mean absolute errors 3.37-3.86 years). We find that BA estimates capture aging at both small and large-scale changes, revealing gross enlargements of ventricles and subarachnoid spaces, as well as lesions, iron accumulations and atrophies that appear throughout the brain. Divergence from expected aging reflected cardiovascular riskfactors and accelerated aging was more pronounced in the frontal lobe. Applying LRP, our study demonstrates how superior deep learning models detect brain-aging in healthy and at-risk individuals throughout adulthood

Artificial intelligence for dementia prevention

INTRODUCTION: A wide range of modifiable risk factors for dementia have been identified. Considerable debate remains about these risk factors, possible interactions between them or with genetic risk, and causality, and how they can help in clinical trial recruitment and drug development. Artificial intelligence (AI) and machine learning (ML) may refine understanding.// METHODS: ML approaches are being developed in dementia prevention. We discuss exemplar uses and evaluate the current applications and limitations in the dementia prevention field.// RESULTS: Risk-profiling tools may help identify high-risk populations for clinical trials; however, their performance needs improvement. New risk-profiling and trial-recruitment tools underpinned by ML models may be effective in reducing costs and improving future trials. ML can inform drug-repurposing efforts and prioritization of disease-modifying therapeutics.// DISCUSSION: ML is not yet widely used but has considerable potential to enhance precision in dementia prevention

Multi-sensor physical activity measurement in early childhood

The purpose of this dissertation was to develop, validate, and implement multi-sensor approaches for measuring physical activity and social/contextual covariates in 2-5 year-old children via wearable-, wireless communication-, and infrared-depth camera-based technologies. In Chapter 2, a three-phased study design was used to validate a method for estimating metered distances between wearable devices using accelerometer-derived Bluetooth signals. Results showed that distances, up to 20 meters, can be predicted between a single Bluetooth beacon and receiver using a Random Forest algorithm. When multiple Bluetooth beacons and receivers were used within the same environment, a moving average filter was required to recover observations lost due to noise. Overall, simulation and validation data suggest that accelerometer-derived Bluetooth signals can be used in studies of physical activity co-participation to 1) estimate metered distances between devices using a single beacon-receiver paradigm, as well as to 2) estimate the proportion of time that devices are proximal when using multiple beacons and receivers. Chapter 3 characterized the relationship between objectively measured physical activity and dyadic spatial proximities in 2 year-olds and their parents. Data revealed that the overall proportions of time that children and their parents spent in total physical activity were positively associated, and time series data revealed that this relationship remained consistent when analyzed hour-to-hour. Time spent engaged in sedentary behavior was also positively associated between children and parents; however, there was no association between child and parent moderate-vigorous physical activity volumes. Dyadic proximity results showed that girls spent more time in joint physical activity with their mothers than boys. Furthermore, children who engaged in >60 minutes of daily moderate-vigorous physical activity spent an additional 30 minutes in joint total physical activity with their mothers each day, on average, when compared to children who engaged in 60 minutes of daily moderate-vigorous physical activity participated in joint physical activity with their mothers across wider relative distances, on average, than did boys who engaged in physical activity at closer relative distances to their mothers. In Chapter 4, an original computer vision algorithm was applied to infrared-depth camera data for the purpose of converting three-dimensional videos into triaxial physical activity signals in young children. Physical activity data were collected in 2-5 year-old children during 20-minute semi-structured, indoor child-parent dyadic play sessions. Play session video data were converted into triaxial physical activity signals using a multi-phased computer vision algorithm for each child. Computer vision-derived triaxial physical activity cut points for 2-5 year-olds were calibrated against a direct observation reference system using a machine learning algorithm. Results revealed that triaxial activity signals, as measured by a dual-sensor camera, can be used to estimate both physical activity intensities and volumes in young children without the use of wearable technology. Collectively, these studies show that multi-sensor approaches to physical activity measurement are a valid means by which to measure physical activity and social/contextual covariates in young children using either wearable sensors or computer vision

Influence of Vitamin D Deficiency on Cardiometabolic Risk in Obesity

Vitamin D deficiency and dysfunctional adipose tissue are involved in the development of cardiometabolic disturbances (eg, hypertension, insulin resistance, type 2 diabetes mellitus, obesity, and dyslipidemia). We studied 50 obese (body mass index [BMI]: 43.5 ± 9.2 kg/m2 ) and 36 normal weight participants (BMI: 22.6 ± 1.9 kg/m2 ). Obese individuals were classified into different subgroups according to medians of observed anthropometric parameters (BMI, body fat percentage, waist circumference, and trunk fat mass). The prevalence of vitamin D deficiency (25-hydroxyvitamin D, 25 (OH)D < 50 nmol/L) was 88% among obese patients and 31% among nonobese individuals; 25(OH)D were lower in the obese group (27.3 ± 13.7 vs 64.6 ± 21.3 nmol/L, p < .001). There was a negative correlation between vitamin D and anthropometric indicators of obesity: BMI: (r = - 0.64, p < .001), waist circumference (r = -0.59; p < .001), and body fat percentage (r = -0.64; p < .001) as well with fasting plasma insulin (r = -0.35; p < .001) and homeostasis model assessment of insulin resistance (r = - 0.35; p < .001). There was a negative correlation between vitamin D level and leptin and resistin (r = -.61; p < .01), while a positive association with adiponectin concentrations were found (r = .7; p < .001). Trend estimation showed that increase in vitamin D level is accompanied by intensive increase in adiponectin concentrations (growth coefficient: 12.13). In conclusion, we observed a higher prevalence of vitamin D deficiency among obese participants and this was associated with a proatherogenic cardiometabolic risk profile. In contrast, a positive trend was established between vitamin D and the protective adipocytokine adiponectin. The clinical relevance of this relationship needs to be investigated in larger studies

Towards the interpretability of deep learning models for multi-modal neuroimaging: Finding structural changes of the ageing brain

Brain-age (BA) estimates based on deep learning are increasingly used as neuroimaging biomarker for brain health; however, the underlying neural features have remained unclear. We combined ensembles of convolutional neural networks with Layer-wise Relevance Propagation (LRP) to detect which brain features contribute to BA. Trained on magnetic resonance imaging (MRI) data of a population-based study (n=2637, 18-82 years), our models estimated age accurately based on single and multiple modalities, regionally restricted and whole-brain images (mean absolute errors 3.37-3.86 years). We find that BA estimates capture aging at both small and large-scale changes, revealing gross enlargements of ventricles and subarachnoid spaces, as well as white matter lesions, and atrophies that appear throughout the brain. Divergence from expected aging reflected cardiovascular risk factors and accelerated aging was more pronounced in the frontal lobe. Applying LRP, our study demonstrates how superior deep learning models detect brain-aging in healthy and at-risk individuals throughout adulthood