Prediction of progression in idiopathic pulmonary fibrosis using CT scans atbaseline: A quantum particle swarm optimization - Random forest approach

Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease characterized by an unpredictable progressive declinein lung function. Natural history of IPF is unknown and the prediction of disease progression at the time ofdiagnosis is notoriously difficult. High resolution computed tomography (HRCT) has been used for the diagnosisof IPF, but not generally for monitoring purpose. The objective of this work is to develop a novel predictivemodel for the radiological progression pattern at voxel-wise level using only baseline HRCT scans. Mainly, thereare two challenges: (a) obtaining a data set of features for region of interest (ROI) on baseline HRCT scans andtheir follow-up status; and (b) simultaneously selecting important features from high-dimensional space, andoptimizing the prediction performance. We resolved the first challenge by implementing a study design andhaving an expert radiologist contour ROIs at baseline scans, depending on its progression status in follow-upvisits. For the second challenge, we integrated the feature selection with prediction by developing an algorithmusing a wrapper method that combines quantum particle swarm optimization to select a small number of featureswith random forest to classify early patterns of progression. We applied our proposed algorithm to analyzeanonymized HRCT images from 50 IPF subjects from a multi-center clinical trial. We showed that it yields aparsimonious model with 81.8% sensitivity, 82.2% specificity and an overall accuracy rate of 82.1% at the ROIlevel. These results are superior to other popular feature selections and classification methods, in that ourmethod produces higher accuracy in prediction of progression and more balanced sensitivity and specificity witha smaller number of selected features. Our work is the first approach to show that it is possible to use onlybaseline HRCT scans to predict progressive ROIs at 6 months to 1year follow-ups using artificial intelligence

Handling boundary constraints for particle swarm optimization in high-dimensional search space

Despite the fact that the popular particle swarm optimizer (PSO) is currently being extensively applied to many real-world problems that often have high-dimensional and complex fitness landscapes, the effects of boundary constraints on PSO have not attracted adequate attention in the literature. However, in accordance with the theoretical analysis in [11], our numerical experiments show that particles tend to fly outside of the boundary in the first few iterations at a very high probability in high-dimensional search spaces. Consequently, the method used to handle boundary violations is critical to the performance of PSO. In this study, we reveal that the widely used random and absorbing bound-handling schemes may paralyze PSO for high-dimensional and complex problems. We also explore in detail the distinct mechanisms responsible for the failures of these two bound-handling schemes. Finally, we suggest that using high-dimensional and complex benchmark functions, such as the composition functions in [19], is a prerequisite to identifying the potential problems in applying PSO to many real-world applications because certain properties of standard benchmark functions make problems inexplicit. © 2011 Elsevier Inc. All rights reserved

Chaotic Quantum Double Delta Swarm Algorithm using Chebyshev Maps: Theoretical Foundations, Performance Analyses and Convergence Issues

Quantum Double Delta Swarm (QDDS) Algorithm is a new metaheuristic algorithm inspired by the convergence mechanism to the center of potential generated within a single well of a spatially co-located double-delta well setup. It mimics the wave nature of candidate positions in solution spaces and draws upon quantum mechanical interpretations much like other quantum-inspired computational intelligence paradigms. In this work, we introduce a Chebyshev map driven chaotic perturbation in the optimization phase of the algorithm to diversify weights placed on contemporary and historical, socially-optimal agents' solutions. We follow this up with a characterization of solution quality on a suite of 23 single-objective functions and carry out a comparative analysis with eight other related nature-inspired approaches. By comparing solution quality and successful runs over dynamic solution ranges, insights about the nature of convergence are obtained. A two-tailed t-test establishes the statistical significance of the solution data whereas Cohen's d and Hedge's g values provide a measure of effect sizes. We trace the trajectory of the fittest pseudo-agent over all function evaluations to comment on the dynamics of the system and prove that the proposed algorithm is theoretically globally convergent under the assumptions adopted for proofs of other closely-related random search algorithms.Comment: 27 pages, 4 figures, 19 table

Improved dynamical particle swarm optimization method for structural dynamics

A methodology to the multiobjective structural design of buildings based on an improved particle swarm optimization algorithm is presented, which has proved to be very efficient and robust in nonlinear problems and when the optimization objectives are in conflict. In particular, the behaviour of the particle swarm optimization (PSO) classical algorithm is improved by dynamically adding autoadaptive mechanisms that enhance the exploration/exploitation trade-off and diversity of the proposed algorithm, avoiding getting trapped in local minima. A novel integrated optimization system was developed, called DI-PSO, to solve this problem which is able to control and even improve the structural behaviour under seismic excitations. In order to demonstrate the effectiveness of the proposed approach, the methodology is tested against some benchmark problems. Then a 3-story-building model is optimized under different objective cases, concluding that the improved multiobjective optimization methodology using DI-PSO is more efficient as compared with those designs obtained using single optimization.Peer ReviewedPostprint (published version

Genetic learning particle swarm optimization

Social learning in particle swarm optimization (PSO) helps collective efficiency, whereas individual reproduction in genetic algorithm (GA) facilitates global effectiveness. This observation recently leads to hybridizing PSO with GA for performance enhancement. However, existing work uses a mechanistic parallel superposition and research has shown that construction of superior exemplars in PSO is more effective. Hence, this paper first develops a new framework so as to organically hybridize PSO with another optimization technique for “learning.” This leads to a generalized “learning PSO” paradigm, the *L-PSO. The paradigm is composed of two cascading layers, the first for exemplar generation and the second for particle updates as per a normal PSO algorithm. Using genetic evolution to breed promising exemplars for PSO, a specific novel *L-PSO algorithm is proposed in the paper, termed genetic learning PSO (GL-PSO). In particular, genetic operators are used to generate exemplars from which particles learn and, in turn, historical search information of particles provides guidance to the evolution of the exemplars. By performing crossover, mutation, and selection on the historical information of particles, the constructed exemplars are not only well diversified, but also high qualified. Under such guidance, the global search ability and search efficiency of PSO are both enhanced. The proposed GL-PSO is tested on 42 benchmark functions widely adopted in the literature. Experimental results verify the effectiveness, efficiency, robustness, and scalability of the GL-PSO