医用超音波における散乱体分布の高解像かつ高感度な画像化に関する研究

Ultrasound imaging as an effective method is widely used in medical diagnosis andNDT (non-destructive testing). In particular, ultrasound imaging plays an important role in medical diagnosis due to its safety, noninvasive, inexpensiveness and real-time compared with other medical imaging techniques. However, in general the ultrasound imaging has more speckles and is low definition than the MRI (magnetic resonance imaging) and X-ray CT (computerized tomography). Therefore, it is important to improve the ultrasound imaging quality. In this study, there are three newproposals. The first is the development of a high sensitivity transducer that utilizes piezoelectric charge directly for FET (field effect transistor) channel control. The second is a proposal of a method for estimating the distribution of small scatterers in living tissue using the empirical Bayes method. The third is a super-resolution imagingmethod of scatterers with strong reflection such as organ boundaries and blood vessel walls. The specific description of each chapter is as follows: Chapter 1: The fundamental characteristics and the main applications of ultrasound are discussed, then the advantages and drawbacks of medical ultrasound are high-lighted. Based on the drawbacks, motivations and objectives of this study are stated. Chapter 2: To overcome disadvantages of medical ultrasound, we advanced our studyin two directions: designing new transducer improves the acquisition modality itself, onthe other hand new signal processing improve the acquired echo data. Therefore, the conventional techniques related to the two directions are reviewed. Chapter 3: For high performance piezoelectric, a structure that enables direct coupling of a PZT (lead zirconate titanate) element to the gate of a MOSFET (metal-oxide semiconductor field-effect transistor) to provide a device called the PZT-FET that acts as an ultrasound receiver was proposed. The experimental analysis of the PZT-FET, in terms of its reception sensitivity, dynamic range and -6 dB reception bandwidth have been investigated. The proposed PZT-FET receiver offers high sensitivity, wide dynamic range performance when compared to the typical ultrasound transducer. Chapter 4: In medical ultrasound imaging, speckle patterns caused by reflection interference from small scatterers in living tissue are often suppressed by various methodologies. However, accurate imaging of small scatterers is important in diagnosis; therefore, we investigated influence of speckle pattern on ultrasound imaging by the empirical Bayesian learning. Since small scatterers are spatially correlated and thereby constitute a microstructure, we assume that scatterers are distributed according to the AR (auto regressive) model with unknown parameters. Under this assumption, the AR parameters are estimated by maximizing the marginal likelihood function, and the scatterers distribution is estimated as a MAP (maximum a posteriori) estimator. The performance of our method is evaluated by simulations and experiments. Through the results, we confirmed that the band limited echo has sufficient information of the AR parameters and the power spectrum of the echoes from the scatterers is properly extrapolated. Chapter 5: The medical ultrasound imaging of strong reflectance scatterers based on the MUSIC algorithm is the main subject of Chapter 5. Previously, we have proposed a super-resolution ultrasound imaging based on multiple TRs (transmissions/receptions) with different carrier frequencies called SCM (super resolution FM-chirp correlation method). In order to reduce the number of required TRs for the SCM, the method has been extended to the SA (synthetic aperture) version called SA-SCM. However, since super-resolution processing is performed for each line data obtained by the RBF (reception beam forming) in the SA-SCM, image discontinuities tend to occur in the lateral direction. Therefore, a new method called SCM-weighted SA is proposed, in this version the SCM is performed on each transducer element, and then the SCM result is used as the weight for RBF. The SCM-weighted SA can generate multiple B-mode images each of which corresponds to each carrier frequency, and the appropriate low frequency images among them have no grating lobes. For a further improvement, instead of simple averaging, the SCM applied to the result of the SCM-weighted SA for all frequencies again, which is called SCM-weighted SA-SCM. We evaluated the effectiveness of all the methods by simulations and experiments. From the results, it can be confirmed that the extension of the SCM framework can help ultrasound imaging reduce grating lobes, perform super-resolution and better SNR(signal-to-noise ratio). Chapter 6: A discussion of the overall content of the thesis as well as suggestions for further development together with the remaining problems are summarized.首都大学東京, 2019-03-25, 博士（工学）首都大学東

Sensor Signal and Information Processing II

In the current age of information explosion, newly invented technological sensors and software are now tightly integrated with our everyday lives. Many sensor processing algorithms have incorporated some forms of computational intelligence as part of their core framework in problem solving. These algorithms have the capacity to generalize and discover knowledge for themselves and learn new information whenever unseen data are captured. The primary aim of sensor processing is to develop techniques to interpret, understand, and act on information contained in the data. The interest of this book is in developing intelligent signal processing in order to pave the way for smart sensors. This involves mathematical advancement of nonlinear signal processing theory and its applications that extend far beyond traditional techniques. It bridges the boundary between theory and application, developing novel theoretically inspired methodologies targeting both longstanding and emergent signal processing applications. The topic ranges from phishing detection to integration of terrestrial laser scanning, and from fault diagnosis to bio-inspiring filtering. The book will appeal to established practitioners, along with researchers and students in the emerging field of smart sensors processing

Vital Signs Monitoring Based On UWB Radar

Contactless detection of human vital sign using radar sensors appears to be a promising technology which integrates communication, biomedicine, computer science etc. The radar-based vital sign detection has been actively investigated in the past decade. Due to the advantages such as wide bandwidth, high resolution, small and portable size etc., ultra-wideband (UWB) radar has received a great deal of attention in the health care field. In this thesis, an X4 series UWB radar developed by Xethru Company is adopted to detect human breathing signals through the radar echo reflected by the chest wall movement caused by breath and heartbeat. The emphasis is placed on the estimation of breathing and heart rate based on several signal processing algorithms. Firstly, the research trend of vital sign detection using radar technology is reviewed, based on which the advantages of contactless detection and UWB radar-based technology are highlighted. Then theoretical basis and core algorithms of radar signals detection are presented. Meanwhile, the detection system based on Xethru UWB radar is introduced. Next, several preprocessing methods including SVD-based clutter and noise removal algorithms, the largest variance-based target detection method, and the autocorrelation-based breathing-like signal identification method are investigated, to extract the significant component containing the vital signs from the received raw radar echo signal. Then the thesis investigates four time-frequency analysis algorithms (fast Fourier transform + band-pass filter (FFT+BPF), empirical mode decomposition (EMD), ensemble empirical mode decomposition (EEMD) and variational mode decomposition (VMD) and compare their performances in estimating breathing rate (BR) and heart rate (HR) in different application scenarios. A python-based vital signs detection system is designed to implement the above-mentioned preprocessing and BR and HR estimation algorithms, based on which a large number of single target experiments are undertaken to evaluate the four estimation algorithms. Specifically, the single target experiments are divided into simple setup and challenging setup. In the simple setup, testees face to radar and keep normal breathing in an almost stationary posture, while in the challenging setup, the testee is allowed to do more actions, such as site sitting, changing the breathing frequency, deep hold the breathing. It is shown that the FFT+BPF algorithm gives the highest accuracy and the fastest calculation speed under the simple setup, while in a challenging setup, the VMD algorithm has the highest accuracy and the widest applicability. Finally, double targets breathing signal detection at different distances to the radar are undertaken, aiming to observe whether the breathing signals of two targets will interfere with each other. We found that when two objects are not located at the same distance to the radar, the object closer to the radar will not affect the breath detection of the object far from the radar. When the two targets are located at the same distance, the 'Shading effect' appears in the two breathing signals and only VMD algorithm can separate the breathing signals of the targets