Large-scale event extraction from literature with multi-level gene normalization

Text mining for the life sciences aims to aid database curation, knowledge summarization and information retrieval through the automated processing of biomedical texts. To provide comprehensive coverage and enable full integration with existing biomolecular database records, it is crucial that text mining tools scale up to millions of articles and that their analyses can be unambiguously linked to information recorded in resources such as UniProt, KEGG, BioGRID and NCBI databases. In this study, we investigate how fully automated text mining of complex biomolecular events can be augmented with a normalization strategy that identifies biological concepts in text, mapping them to identifiers at varying levels of granularity, ranging from canonicalized symbols to unique gene and proteins and broad gene families. To this end, we have combined two state-of-the-art text mining components, previously evaluated on two community-wide challenges, and have extended and improved upon these methods by exploiting their complementary nature. Using these systems, we perform normalization and event extraction to create a large-scale resource that is publicly available, unique in semantic scope, and covers all 21.9 million PubMed abstracts and 460 thousand PubMed Central open access full-text articles. This dataset contains 40 million biomolecular events involving 76 million gene/protein mentions, linked to 122 thousand distinct genes from 5032 species across the full taxonomic tree. Detailed evaluations and analyses reveal promising results for application of this data in database and pathway curation efforts. The main software components used in this study are released under an open-source license. Further, the resulting dataset is freely accessible through a novel API, providing programmatic and customized access (http://www.evexdb.org/api/v001/). Finally, to allow for large-scale bioinformatic analyses, the entire resource is available for bulk download from http://evexdb.org/download/, under the Creative Commons -Attribution - Share Alike (CC BY-SA) license

i-JEN: Visual interactive Malaysia crime news retrieval system

Supporting crime news investigation involves a mechanism to help monitor the current and past status of criminal events. We believe this could be well facilitated by focusing on the user interfaces and the event crime model aspects. In this paper we discuss on a development of Visual Interactive Malaysia Crime News Retrieval System (i-JEN) and describe the approach, user studies and planned, the system architecture and future plan. Our main objectives are to construct crime-based event; investigate the use of crime-based event in improving the classification and clustering; develop an interactive crime news retrieval system; visualize crime news in an effective and interactive way; integrate them into a usable and robust system and evaluate the usability and system performance. The system will serve as a news monitoring system which aims to automatically organize, retrieve and present the crime news in such a way as to support an effective monitoring, searching, and browsing for the target users groups of general public, news analysts and policemen or crime investigators. The study will contribute to the better understanding of the crime data consumption in the Malaysian context as well as the developed system with the visualisation features to address crime data and the eventual goal of combating the crimes

Mining structured Petri nets for the visualization of process behavior

Visualization is essential for understanding the models obtained by process mining. Clear and efficient visual representations make the embedded information more accessible and analyzable. This work presents a novel approach for generating process models with structural properties that induce visually friendly layouts. Rather than generating a single model that captures all behaviors, a set of Petri net models is delivered, each one covering a subset of traces of the log. The models are mined by extracting slices of labelled transition systems with specific properties from the complete state space produced by the process logs. In most cases, few Petri nets are sufficient to cover a significant part of the behavior produced by the log.Peer ReviewedPostprint (author's final draft