29,249 research outputs found
Automated Home Oxygen Delivery for Patients with COPD and Respiratory Failure: A New Approach
Long-term oxygen therapy (LTOT) has become standard care for the treatment of patients with chronic obstructive pulmonary disease (COPD) and other severe hypoxemic lung diseases. The use of new portable O-2 concentrators (POC) in LTOT is being expanded. However, the issue of oxygen titration is not always properly addressed, since POCs rely on proper use by patients. The robustness of algorithms and the limited reliability of current oximetry sensors are hindering the effectiveness of new approaches to closed-loop POCs based on the feedback of blood oxygen saturation. In this study, a novel intelligent portable oxygen concentrator (iPOC) is described. The presented iPOC is capable of adjusting the O-2 flow automatically by real-time classifying the intensity of a patient's physical activity (PA). It was designed with a group of patients with COPD and stable chronic respiratory failure. The technical pilot test showed a weighted accuracy of 91.1% in updating the O-2 flow automatically according to medical prescriptions, and a general improvement in oxygenation compared to conventional POCs. In addition, the usability achieved was high, which indicated a significant degree of user satisfaction. This iPOC may have important benefits, including improved oxygenation, increased compliance with therapy recommendations, and the promotion of PA
Mapping constrained optimization problems to quantum annealing with application to fault diagnosis
Current quantum annealing (QA) hardware suffers from practical limitations
such as finite temperature, sparse connectivity, small qubit numbers, and
control error. We propose new algorithms for mapping boolean constraint
satisfaction problems (CSPs) onto QA hardware mitigating these limitations. In
particular we develop a new embedding algorithm for mapping a CSP onto a
hardware Ising model with a fixed sparse set of interactions, and propose two
new decomposition algorithms for solving problems too large to map directly
into hardware.
The mapping technique is locally-structured, as hardware compatible Ising
models are generated for each problem constraint, and variables appearing in
different constraints are chained together using ferromagnetic couplings. In
contrast, global embedding techniques generate a hardware independent Ising
model for all the constraints, and then use a minor-embedding algorithm to
generate a hardware compatible Ising model. We give an example of a class of
CSPs for which the scaling performance of D-Wave's QA hardware using the local
mapping technique is significantly better than global embedding.
We validate the approach by applying D-Wave's hardware to circuit-based
fault-diagnosis. For circuits that embed directly, we find that the hardware is
typically able to find all solutions from a min-fault diagnosis set of size N
using 1000N samples, using an annealing rate that is 25 times faster than a
leading SAT-based sampling method. Further, we apply decomposition algorithms
to find min-cardinality faults for circuits that are up to 5 times larger than
can be solved directly on current hardware.Comment: 22 pages, 4 figure
Continuous maintenance and the future – Foundations and technological challenges
High value and long life products require continuous maintenance throughout their life cycle to achieve required performance with optimum through-life cost. This paper presents foundations and technologies required to offer the maintenance service. Component and system level degradation science, assessment and modelling along with life cycle ‘big data’ analytics are the two most important knowledge and skill base required for the continuous maintenance. Advanced computing and visualisation technologies will improve efficiency of the maintenance and reduce through-life cost of the product. Future of continuous maintenance within the Industry 4.0 context also identifies the role of IoT, standards and cyber security
Directed networks as a novel way to describe and analyze cardiac excitation : directed graph mapping
Networks provide a powerful methodology with applications in a variety of biological, technological and social systems such as analysis of brain data, social networks, internet search engine algorithms, etc. To date, directed networks have not yet been applied to characterize the excitation of the human heart. In clinical practice, cardiac excitation is recorded by multiple discrete electrodes. During (normal) sinus rhythm or during cardiac arrhythmias, successive excitation connects neighboring electrodes, resulting in their own unique directed network. This in theory makes it a perfect fit for directed network analysis. In this study, we applied directed networks to the heart in order to describe and characterize cardiac arrhythmias. Proof-of-principle was established using in-silico and clinical data. We demonstrated that tools used in network theory analysis allow determination of the mechanism and location of certain cardiac arrhythmias. We show that the robustness of this approach can potentially exceed the existing state-of-the art methodology used in clinics. Furthermore, implementation of these techniques in daily practice can improve the accuracy and speed of cardiac arrhythmia analysis. It may also provide novel insights in arrhythmias that are still incompletely understood
- …