On-Chip Integrated Functional Near Infra-Red Spectroscopy (fNIRS) Photoreceiver for Portable Brain Imaging

RÉSUMÉ L'imagerie cérébrale fonctionnelle utilisant la Spectroscopie Fonctionnelle Proche-Infrarouge (SFPI) propose un outil portatif et non invasif de surveillance de l'oxygénation du sang. SFPI est une technique de haute résolution temporelle non invasive, sûr, peu intrusive en temps réel et pour l'imagerie cérébrale à long terme. Il permet de détecter des signaux hémodynamiques à la fois rapides et neuronaux ou lents. Outre les avantages importants des systèmes SFPI, ils souffrent encore de quelques inconvénients, notamment d’une faible résolution spatiale, d’un bruit de niveau modérément élevé et d’une grande sensibilité au mouvement. Afin de surmonter les limites des systèmes actuellement disponibles de SFPI non-portables, dans cette thèse, nous en avons introduit une nouvelle de faible puissance, miniaturisée sur une puce photodétecteur frontal destinée à des systèmes de SFPI portables. Elle contient du silicium photodiode à avalanche (SiAPD), un amplificateur de transimpédance (TIA), et « Quench-Reset », circuits mis en oeuvre en utilisant les technologies CMOS standards pour fonctionner dans les deux modes : linéaire et Geiger. Ainsi, elle peut être appliquée pour les deux fNIRS : en onde continue (CW- SFPI) et pour des applications de comptage de photon unique. Plusieurs SiAPDs ont été mises en oeuvre dans de nouvelles structures et formes (rectangulaires, octogonales, double APDs, imbriquées, netted, quadratiques et hexadecagonal) en utilisant différentes techniques de prévention de la dégradation de bord prématurée. Les principales caractéristiques des SiAPDs sont validées et l'impact de chaque paramètre ainsi que les simulateurs de l'appareil (TCAD, COMSOL, etc) ont été étudiés sur la base de la simulation et de mesure des résultats. Proposées SiAPDs techniques d'exposition avec un gain de grande avalanche, tension faible ventilation et une grande efficacité de détection des photons dans plus de faibles taux de comptage sombres. Trois nouveaux produits à haut gain, bande passante (GBW) et à faible bruit TIA sont introduits basés sur le concept de gain distribué, d’amplificateur logarithmique et sur le rejet automatique du bruit pour être appliqué en mode de fonctionnement linéaire. Le TIA proposé offre une faible consommation, un gain de haute transimpédance, une bande passante ajustable et un très faible bruit d'entrée et de sortie. Le nouveau circuit mixte trempe-reset (MQC) et un MQC contrôlable (CMQC) frontaux offrent une faible puissance, une haute vitesse de comptage de photons avec un commandable de temps de hold-off et temps de réinitialiser. La première intégration sur puce de SiAPDs avec TIA et Photon circuit de comptage a été démontrée et montre une amélioration de l'efficacité de la photodétection, spécialement en ce qui concerne la sensibilité, la consommation d'énergie et le rapport signal sur bruit.----------ABSTRACT Optical brain imaging using functional near infra-red spectroscopy (fNIRS) offers a direct and noninvasive tool for monitoring of blood oxygenation. fNIRS is a noninvasive, safe, minimally intrusive, and high temporal-resolution technique for real-time and long-term brain imaging. It allows detecting both fast-neuronal and slow-hemodynamic signals. Besides the significant advantages of fNIRS systems, they still suffer from few drawbacks including low spatial- resolution, moderately high-level noise and high-sensitivity to movement. In order to overcome the limitations of currently available non-portable fNIRS systems, we have introduced a new low-power, miniaturized on-chip photodetector front-end intended for portable fNIRS systems. It includes silicon avalanche photodiode (SiAPD), Transimpedance amplifier (TIA), and Quench- Reset circuitry implemented using standard CMOS technologies to operate in both linear and Geiger modes. So it can be applied for both continuous-wave fNIRS (CW-fNIRS) and also single-photon counting applications. Several SiAPDs have been implemented in novel structures and shapes (Rectangular, Octagonal, Dual, Nested, Netted, Quadratic and Hexadecagonal) using different premature edge breakdown prevention techniques. The main characteristics of the SiAPDs are validated and the impact of each parameter and the device simulators (TCAD, COMSOL, etc.) have been studied based on the simulation and measurement results. Proposed techniques exhibit SiAPDs with high avalanche-gain (up to 119), low breakdown-voltage (around 12V) and high photon-detection efficiency (up to 72% in NIR region) in additional to a low dark- count rate (down to 30Hz at 1V excess bias voltage). Three new high gain-bandwidth product (GBW) and low-noise TIAs are introduced and implemented based on distributed-gain concept, logarithmic-amplification and automatic noise-rejection and have been applied in linear-mode of operation. The implemented TIAs offer a power-consumption around 0.4 mW, transimpedance gain of 169 dBΩ, and input-output current/voltage noises in fA/pV range accompanied with ability to tune the gain, bandwidth and power-consumption in a wide range. The implemented mixed quench-reset circuit (MQC) and controllable MQC (CMQC) front-ends offer a quenchtime of 10ns, a maximum power-consumption of 0.4 mW, with a controllable hold-off and resettimes. The on-chip integration of SiAPDs with TIA and photon-counting circuitries has been demonstrated showing improvement of the photodetection-efficiency, specially regarding to the sensitivity, power-consumption and signal-to-noise ratio (SNR) characteristics

Development of a Nano-Illumination Microscope

[eng] This doctoral thesis proposes and explores a new approach to lensless microscopy, focusing on making high resolution imaging ubiquitous and low cost. A short introduction to microscopy frames the state of current techniques: Abbe’s law limits the resolving power for visible light microscopes with lenses, techniques using UV, X-rays, or electrons are incompatible with live samples and all of them, including super-resolution microscopy methods, are complex devices not suitable for being used in the field as mobile devices. Some lensless microscopy methods try to solve these issues. The microscopy method is named Nano Illumination Microscopy (NIM) because it relies on using nanometric light sources in an ordered array to illuminate a sample placed in close proximity to them, and a photodetector at the other side to measure the amount of light arriving from each LED. In a setup like this, the resolving power is provided by the nano-LEDs and their distribution instead of the sensing devices, as is the case in the other methods. Since the resolving power depends on the pitch of the LED array, this method also opens a path to obtain super-resolution images, depending only on obtaining LED arrays with pitches smaller than Abbe’s limit for the wavelength. After the introduction to microscopy setting the context of the thesis, the thesis continues explaining the main components used to build the microscope: a SPAD camera, designed within the context of this work, and the electronics to control the nano-LED array. The third chapter of this thesis provides an overview of the microscopy method and its fundaments, exploring the requirements and capabilities. Image formation is first introduced with simulations, and this information is then used to build the very first prototype, a microscope capable of forming 8x8 pixel images -since that is the form factor of the LED array used, with LEDs of 5 μm in size (and 10 μm in pitch). The first results from this technique are presented and compared with the simulations, showing the agreement between both, validating the method, and offering insight on building the next prototypes, which will use smaller LEDs in an attempt to study the technological limits. The thesis continues with the work done in search of the limits of the technique, building and testing new improved versions of the microscope and confronting the limitations which arise. Some of those came from the structure of the LED arrays themselves: while nano-LEDs well below the sizes used have been reported, those have been isolated structures or non individually addressable. Selecting exactly which LED will emit is one of the main problems to solve since with increasingly large arrays, the connections required increase exponentially until routing is impossible. The thesis also studies this problem, as the LED arrays were changed in search of the proper solution. This implied moving from a direct addressing strategy, in which each LED was selected individually, towards a matrix-addressing format, in which the LEDs are selected by polarising the appropriate row and columns. The microscopy technique is validated and the more advanced prototypes presented. Images with a maximum resolving power of 800 nm are shown, and the results discussed, since the physical limitations on fabricating the chips limit the maximum resolving power below what was theoretically expected. The thesis also offers a short overview into the future of the Nano Illumination Microscopy technique.[cat] Aquesta tesi doctoral proposa i explora una nova aproximació a la microscopia sense lents, amb la intenció de facilitar l’obtenció d’imatges d’alta resolució amb baix cost i disponible arreu. S’ha batejat aquest mètode de microscòpia com a Microscopia de Nano-Il·luminació (MNI) perquè la imatge es construeix a partir de fonts de llum de mida nanomètrica distribuïdes en una matriu que il·luminen la mostra de forma consecutiva i ordenada. Un sensor a l’altre costat recull la intensitat de llum que arriba de cada LED, creant un mapa de l’objecte observat. Aquest mètode fa que la resolució de les imatges depengui de la mida i distribució dels LEDs, en comptes de la del sensor com és el cas convencionalment, obrint la porta a noves integracions. En la tesi s’ofereix una introducció general a la microscòpia abans d’entrar a detallar els components del microscopi i com s’integren per muntar-lo. A continuació es presenta i s’estudia el funcionament del mètode, començant amb simulacions i seguint amb la construcció del primer prototip de microscopi amb el que s’obtenen les primeres imatges. La tesi procedeix a continuació a investigar els límits actuals de la tècnica de microscòpia, utilitzant noves versions de la matriu de LEDs i estratègies alternatives per intentar superar-ne les complicacions tècniques. Així, s’obtenen imatges amb una resolució de 800 nm i es discuteix la problemàtica d’implementar dispositius que s’aproximin a les expectatives teòriques per la tècnica

Radiation Tolerant Electronics, Volume II

Research on radiation tolerant electronics has increased rapidly over the last few years, resulting in many interesting approaches to model radiation effects and design radiation hardened integrated circuits and embedded systems. This research is strongly driven by the growing need for radiation hardened electronics for space applications, high-energy physics experiments such as those on the large hadron collider at CERN, and many terrestrial nuclear applications, including nuclear energy and safety management. With the progressive scaling of integrated circuit technologies and the growing complexity of electronic systems, their ionizing radiation susceptibility has raised many exciting challenges, which are expected to drive research in the coming decade.After the success of the first Special Issue on Radiation Tolerant Electronics, the current Special Issue features thirteen articles highlighting recent breakthroughs in radiation tolerant integrated circuit design, fault tolerance in FPGAs, radiation effects in semiconductor materials and advanced IC technologies and modelling of radiation effects

High step up DC-DC converter topology for PV systems and electric vehicles

This thesis presents new high step-up DC-DC converters for photovoltaic and electric vehicle applications. An asymmetric flyback-forward DC-DC converter is proposed for the PV system controlled by the MPPT algorithm. The second converter is a modular switched-capacitor DC-DC converter, it has the capability to operate with transistor and capacitor open-circuit faults in every module. The results from simulations and tests of the asymmetric DC-DC converters have suggested that the proposed converter has a 5% to 10% voltage gain ratio increased to the symmetric structures among 100W – 300W power (such as [3]) range while maintaining efficiency of 89%-93% when input voltage is in the range of 25 – 30 V. they also indicated that the softswitching technique has been achieved, which significantly reduce the power loss by 1.7%, which exceeds the same topology of the proposed converter without the softswitching technique. Moreover, the converters can maintain rated outputs under main transistor open circuit fault situation or capacitor open circuit faults. The simulation and test results of the proposed modularized switched-capacitor DC-DC converters indicate that the proposed converter has the potential of extension, it can be embedded with infinite module in simulation results, however, during experiment. The sign open circuit fault to the transistors and capacitors would have low impact to the proposed converters, only the current ripple on the input source would increase around 25% for 4-module switched-capacitor DC-DC converters. The developed converters can be applied to many applications where DC-DC voltage conversion is alighted. In addition to PVs and EVs. Since they can ride through some electrical faults in the devices, the developed converter will have economic implications to improve the system efficiency and reliability

An aesthetic for sustainable interactions in product-service systems?

Copyright @ 2012 Greenleaf PublishingEco-efficient Product-Service System (PSS) innovations represent a promising approach to sustainability. However the application of this concept is still very limited because its implementation and diffusion is hindered by several barriers (cultural, corporate and regulative ones). The paper investigates the barriers that affect the attractiveness and acceptation of eco-efficient PSS alternatives, and opens the debate on the aesthetic of eco-efficient PSS, and the way in which aesthetic could enhance some specific inner qualities of this kinds of innovations. Integrating insights from semiotics, the paper outlines some first research hypothesis on how the aesthetic elements of an eco-efficient PSS could facilitate user attraction, acceptation and satisfaction

Miniaturized Silicon Photodetectors

Silicon (Si) technologies provide an excellent platform for the design of microsystems where photonic and microelectronic functionalities are monolithically integrated on the same substrate. In recent years, a variety of passive and active Si photonic devices have been developed, and among them, photodetectors have attracted particular interest from the scientific community. Si photodiodes are typically designed to operate at visible wavelengths, but, unfortunately, their employment in the infrared (IR) range is limited due to the neglectable Si absorption over 1100 nm, even though the use of germanium (Ge) grown on Si has historically allowed operations to be extended up to 1550 nm. In recent years, significant progress has been achieved both by improving the performance of Si-based photodetectors in the visible range and by extending their operation to infrared wavelengths. Near-infrared (NIR) SiGe photodetectors have been demonstrated to have a “zero change” CMOS process flow, while the investigation of new effects and structures has shown that an all-Si approach could be a viable option to construct devices comparable with Ge technology. In addition, the capability to integrate new emerging 2D and 3D materials with Si, together with the capability of manufacturing devices at the nanometric scale, has led to the development of new device families with unexpected performance. Accordingly, this Special Issue of Micromachines seeks to showcase research papers, short communications, and review articles that show the most recent advances in the field of silicon photodetectors and their respective applications

Intelligent Circuits and Systems

ICICS-2020 is the third conference initiated by the School of Electronics and Electrical Engineering at Lovely Professional University that explored recent innovations of researchers working for the development of smart and green technologies in the fields of Energy, Electronics, Communications, Computers, and Control. ICICS provides innovators to identify new opportunities for the social and economic benefits of society.　 This conference bridges the gap between academics and R&D institutions, social visionaries, and experts from all strata of society to present their ongoing research activities and foster research relations between them. It provides opportunities for the exchange of new ideas, applications, and experiences in the field of smart technologies and finding global partners for future collaboration. The ICICS-2020 was conducted in two broad categories, Intelligent Circuits & Intelligent Systems and Emerging Technologies in Electrical Engineering