Interpretable Clustering using Unsupervised Binary Trees

We herein introduce a new method of interpretable clustering that uses unsupervised binary trees. It is a three-stage procedure, the first stage of which entails a series of recursive binary splits to reduce the heterogeneity of the data within the new subsamples. During the second stage (pruning), consideration is given to whether adjacent nodes can be aggregated. Finally, during the third stage (joining), similar clusters are joined together, even if they do not descend from the same node originally. Consistency results are obtained, and the procedure is used on simulated and real data sets.Comment: 25 pages, 6 figure

Mapping Topographic Structure in White Matter Pathways with Level Set Trees

Fiber tractography on diffusion imaging data offers rich potential for describing white matter pathways in the human brain, but characterizing the spatial organization in these large and complex data sets remains a challenge. We show that level set trees---which provide a concise representation of the hierarchical mode structure of probability density functions---offer a statistically-principled framework for visualizing and analyzing topography in fiber streamlines. Using diffusion spectrum imaging data collected on neurologically healthy controls (N=30), we mapped white matter pathways from the cortex into the striatum using a deterministic tractography algorithm that estimates fiber bundles as dimensionless streamlines. Level set trees were used for interactive exploration of patterns in the endpoint distributions of the mapped fiber tracks and an efficient segmentation of the tracks that has empirical accuracy comparable to standard nonparametric clustering methods. We show that level set trees can also be generalized to model pseudo-density functions in order to analyze a broader array of data types, including entire fiber streamlines. Finally, resampling methods show the reliability of the level set tree as a descriptive measure of topographic structure, illustrating its potential as a statistical descriptor in brain imaging analysis. These results highlight the broad applicability of level set trees for visualizing and analyzing high-dimensional data like fiber tractography output

Analysis of approximate nearest neighbor searching with clustered point sets

We present an empirical analysis of data structures for approximate nearest neighbor searching. We compare the well-known optimized kd-tree splitting method against two alternative splitting methods. The first, called the sliding-midpoint method, which attempts to balance the goals of producing subdivision cells of bounded aspect ratio, while not producing any empty cells. The second, called the minimum-ambiguity method is a query-based approach. In addition to the data points, it is also given a training set of query points for preprocessing. It employs a simple greedy algorithm to select the splitting plane that minimizes the average amount of ambiguity in the choice of the nearest neighbor for the training points. We provide an empirical analysis comparing these two methods against the optimized kd-tree construction for a number of synthetically generated data and query sets. We demonstrate that for clustered data and query sets, these algorithms can provide significant improvements over the standard kd-tree construction for approximate nearest neighbor searching.Comment: 20 pages, 8 figures. Presented at ALENEX '99, Baltimore, MD, Jan 15-16, 199