A Survey on Deep Learning in Medical Image Analysis

Deep learning algorithms, in particular convolutional networks, have rapidly become a methodology of choice for analyzing medical images. This paper reviews the major deep learning concepts pertinent to medical image analysis and summarizes over 300 contributions to the field, most of which appeared in the last year. We survey the use of deep learning for image classification, object detection, segmentation, registration, and other tasks and provide concise overviews of studies per application area. Open challenges and directions for future research are discussed.Comment: Revised survey includes expanded discussion section and reworked introductory section on common deep architectures. Added missed papers from before Feb 1st 201

automatic features recognition for anthropometry

Abstract For the purpose of reducing uncertainties in the measurements of morphologically complex biological objects, the authors present a new automatic method, which takes advantage from the representation of the object in the form of the 3D geometric model obtained from CT-scans or 3D scanning. In this paper, the method is verified in real cases and compared with the traditional approaches

A multi-center milestone study of clinical vertebral CT segmentation

A multiple center milestone study of clinical vertebra segmentation is presented in this paper. Vertebra segmentation is a fundamental step for spinal image analysis and intervention. The first half of the study was conducted in the spine segmentation challenge in 2014 International Conference on Medical Image Computing and Computer Assisted Intervention (MICCAI) Workshop on Computational Spine Imaging (CSI 2014). The objective was to evaluate the performance of several state-of-the-art vertebra segmentation algorithms on computed tomography (CT) scans using ten training and five testing dataset, all healthy cases; the second half of the study was conducted after the challenge, where additional 5 abnormal cases are used for testing to evaluate the performance under abnormal cases. Dice coefficients and absolute surface distances were used as evaluation metrics. Segmentation of each vertebra as a single geometric unit, as well as separate segmentation of vertebra substructures, was evaluated. Five teams participated in the comparative study. The top performers in the study achieved Dice coefficient of 0.93 in the upper thoracic, 0.95 in the lower thoracic and 0.96 in the lumbar spine for healthy cases, and 0.88 in the upper thoracic, 0.89 in the lower thoracic and 0.92 in the lumbar spine for osteoporotic and fractured cases. The strengths and weaknesses of each method as well as future suggestion for improvement are discussed. This is the first multi-center comparative study for vertebra segmentation methods, which will provide an up-to-date performance milestone for the fast growing spinal image analysis and intervention

Patch-based Corner Detection for Cervical Vertebrae in X-ray Images

Corners hold vital information about size, shape and morphology of a vertebra in an x-ray image, and recent literature [1, 2] has shown promising performance for detecting vertebral corners using a Hough forest-based architecture. To provide spatial context, this method generates a set of 12 patches around a vertebra and uses a machine learning approach to predict corners of a vertebral body through a voting process. In this paper, we extend this framework in terms of patch generation and prediction methods. During patch generation, the square region of interest has been replaced with data-driven rectangular and trapezoidal region of interest which better aligns the patches to the vertebral body geometry, resulting in more discriminative feature vectors. The corner estimation or the prediction stage has been improved by utilising more efficient voting process using a single kernel density estimation. In addition, advanced and more complex feature vectors are introduced. We also present a thorough evaluation of the framework with different patch generation methods, forest training mechanisms and prediction methods. In order to compare the performance of this framework with a more general method, a novel multi-scale Harris corner detector-based approach is introduced that incorporates a spatial prior through a naive Bayes method. All these methods have been tested on a dataset of 90 X-ray images and achieved an average corner localization error of 2.01 mm, representing a 33% improvement in localisation accuracy compared to the previous state-of-the-art method [2]

Automatic vertebrae localization from CT scans using volumetric descriptors

The localization and identification of vertebrae in spinal CT images plays an important role in many clinical applications, such as spinal disease diagnosis, surgery planning, and post-surgery assessment. However, automatic vertebrae localization presents numerous challenges due to partial visibility, appearance similarity of different vertebrae, varying data quality, and the presence of pathologies. Most existing methods require prior information on which vertebrae are present in a scan, and perform poorly on pathological cases, making them of little practical value. In this paper we describe three novel types of local information descriptors which are used to build more complex contextual features, and train a random forest classifier. The three features are progressively more complex, systematically addressing a greater number of limitations of the current state of the art.Postprin

Hough Forest-based Corner Detection for Cervical Spine Radiographs

The cervical spine (neck region) is highly sensitive to trauma related injuries, which must be analysed carefully by emergency physicians. In this work, we propose a Hough Forest-based corner detection method for cervical spine radiographs, as a first step towards a computer-aided diagnostic tool. We propose a novel patch-based model based on two-stage supervised learning (classification and regression) to estimate the corners of cervical vertebral bodies. Our method is evaluated using 106 cervical x-ray images consisting of 530 vertebrae and 2120 corners, which have been demarcated manually by an expert radiographer. The results show promising performance of the proposed algorithm, with a lowest median error of 1.98 m

Medical imaging analysis with artificial neural networks

Given that neural networks have been widely reported in the research community of medical imaging, we provide a focused literature survey on recent neural network developments in computer-aided diagnosis, medical image segmentation and edge detection towards visual content analysis, and medical image registration for its pre-processing and post-processing, with the aims of increasing awareness of how neural networks can be applied to these areas and to provide a foundation for further research and practical development. Representative techniques and algorithms are explained in detail to provide inspiring examples illustrating: (i) how a known neural network with fixed structure and training procedure could be applied to resolve a medical imaging problem; (ii) how medical images could be analysed, processed, and characterised by neural networks; and (iii) how neural networks could be expanded further to resolve problems relevant to medical imaging. In the concluding section, a highlight of comparisons among many neural network applications is included to provide a global view on computational intelligence with neural networks in medical imaging