Segmentation of ultrasound images of thyroid nodule for assisting fine needle aspiration cytology

The incidence of thyroid nodule is very high and generally increases with the age. Thyroid nodule may presage the emergence of thyroid cancer. The thyroid nodule can be completely cured if detected early. Fine needle aspiration cytology is a recognized early diagnosis method of thyroid nodule. There are still some limitations in the fine needle aspiration cytology, and the ultrasound diagnosis of thyroid nodule has become the first choice for auxiliary examination of thyroid nodular disease. If we could combine medical imaging technology and fine needle aspiration cytology, the diagnostic rate of thyroid nodule would be improved significantly. The properties of ultrasound will degrade the image quality, which makes it difficult to recognize the edges for physicians. Image segmentation technique based on graph theory has become a research hotspot at present. Normalized cut (Ncut) is a representative one, which is suitable for segmentation of feature parts of medical image. However, how to solve the normalized cut has become a problem, which needs large memory capacity and heavy calculation of weight matrix. It always generates over segmentation or less segmentation which leads to inaccurate in the segmentation. The speckle noise in B ultrasound image of thyroid tumor makes the quality of the image deteriorate. In the light of this characteristic, we combine the anisotropic diffusion model with the normalized cut in this paper. After the enhancement of anisotropic diffusion model, it removes the noise in the B ultrasound image while preserves the important edges and local details. This reduces the amount of computation in constructing the weight matrix of the improved normalized cut and improves the accuracy of the final segmentation results. The feasibility of the method is proved by the experimental results.Comment: 15pages,13figure

Modified Canny Detector-based Active Contour for Segmentation

In the present work, an integrated modified canny detector and an active contour were proposed for automated medical image segmentation. Since the traditional canny detector (TCD) detects only the edge’s pixels, which are insufficient for labelling the image, a shape feature was extracted to select the initial region of interest ‘IROI’ as an initial mask for the active contour without edge (ACWE), using a proposed modified canny detector (MCD). This procedure overcomes the drawback of the manual initialization of the mask location and shape in the traditional ACWE, which is sensitive to the shape of region of region of interest (ROI). The proposed method solves this problem by selecting the initial location and shape of the IROI using the MCD. Also, a post-processing stage was applied for more cleaning and smoothing the ROI. A practical computational time is achieved as the proposed system requires less than 5 minutes, which is significantly less than the required time using the traditional ACWE. The results proved the ability of the proposed method for medical image segmentation with average dice 87.54%

Modified Canny Detector-based Active Contour for Segmentation

In the present work, an integrated modified canny detector and an active contour were proposed for automated medical image segmentation. Since the traditional canny detector (TCD) detects only the edge’s pixels, which are insufficient for labelling the image, a shape feature was extracted to select the initial region of interest ‘IROI’ as an initial mask for the active contour without edge (ACWE), using a proposed modified canny detector (MCD). This procedure overcomes the drawback of the manual initialization of the mask location and shape in the traditional ACWE, which is sensitive to the shape of region of region of interest (ROI). The proposed method solves this problem by selecting the initial location and shape of the IROI using the MCD. Also, a post-processing stage was applied for more cleaning and smoothing the ROI. A practical computational time is achieved as the proposed system requires less than 5 minutes, which is significantly less than the required time using the traditional ACWE. The results proved the ability of the proposed method for medical image segmentation with average dice 87.54%

Liver CT enhancement using Fractional Differentiation and Integration

In this paper, a digital image filter is proposed to enhance the Liver CT image for improving the classification of tumors area in an infected Liver. The enhancement process is based on improving the main features within the image by utilizing the Fractional Differential and Integral in the wavelet sub-bands of an image. After enhancement, different features were extracted such as GLCM, GRLM, and LBP, among others. Then, the areas/cells are classified into tumor or non-tumor, using different models of classifiers to compare our proposed model with the original image and various established filters. Each image is divided into 15x15 non-overlapping blocks, to extract the desired features. The SVM, Random Forest, J48 and Simple Cart were trained on a supplied dataset, different from the test dataset. Finally, the block cells are identified whether they are classified as tumor or not. Our approach is validated on a group of patients’ CT liver tumor datasets. The experiment results demonstrated the efficiency of enhancement in the proposed technique

A Total Fractional-Order Variation Model for Image Restoration with Non-homogeneous Boundary Conditions and its Numerical Solution

To overcome the weakness of a total variation based model for image restoration, various high order (typically second order) regularization models have been proposed and studied recently. In this paper we analyze and test a fractional-order derivative based total $\alpha$-order variation model, which can outperform the currently popular high order regularization models. There exist several previous works using total $\alpha$-order variations for image restoration; however first no analysis is done yet and second all tested formulations, differing from each other, utilize the zero Dirichlet boundary conditions which are not realistic (while non-zero boundary conditions violate definitions of fractional-order derivatives). This paper first reviews some results of fractional-order derivatives and then analyzes the theoretical properties of the proposed total $\alpha$-order variational model rigorously. It then develops four algorithms for solving the variational problem, one based on the variational Split-Bregman idea and three based on direct solution of the discretise-optimization problem. Numerical experiments show that, in terms of restoration quality and solution efficiency, the proposed model can produce highly competitive results, for smooth images, to two established high order models: the mean curvature and the total generalized variation.Comment: 26 page

A fuzzy feature fusion method for auto-segmentation of gliomas with multi-modality diffusion and perfusion magnetic resonance images in radiotherapy

The difusion and perfusion magnetic resonance (MR) images can provide functional information about tumour and enable more sensitive detection of the tumour extent. We aimed to develop a fuzzy feature fusion method for auto-segmentation of gliomas in radiotherapy planning using multi-parametric functional MR images including apparent difusion coefcient (ADC), fractional anisotropy (FA) and relative cerebral blood volume (rCBV). For each functional modality, one histogram-based fuzzy model was created to transform image volume into a fuzzy feature space. Based on the fuzzy fusion result of the three fuzzy feature spaces, regions with high possibility belonging to tumour were generated automatically. The auto-segmentations of tumour in structural MR images were added in fnal autosegmented gross tumour volume (GTV). For evaluation, one radiation oncologist delineated GTVs for nine patients with all modalities. Comparisons between manually delineated and auto-segmented GTVs showed that, the mean volume diference was 8.69% (±5.62%); the mean Dice’s similarity coefcient (DSC) was 0.88 (±0.02); the mean sensitivity and specifcity of auto-segmentation was 0.87 (±0.04) and 0.98 (±0.01) respectively. High accuracy and efciency can be achieved with the new method, which shows potential of utilizing functional multi-parametric MR images for target defnition in precision radiation treatment planning for patients with gliomas