Multimodal Data Fusion and Quantitative Analysis for Medical Applications

Medical big data is not only enormous in its size, but also heterogeneous and complex in its data structure, which makes conventional systems or algorithms difficult to process. These heterogeneous medical data include imaging data (e.g., Positron Emission Tomography (PET), Computerized Tomography (CT), Magnetic Resonance Imaging (MRI)), and non-imaging data (e.g., laboratory biomarkers, electronic medical records, and hand-written doctor notes). Multimodal data fusion is an emerging vital field to address this urgent challenge, aiming to process and analyze the complex, diverse and heterogeneous multimodal data. The fusion algorithms bring great potential in medical data analysis, by 1) taking advantage of complementary information from different sources (such as functional-structural complementarity of PET/CT images) and 2) exploiting consensus information that reflects the intrinsic essence (such as the genetic essence underlying medical imaging and clinical symptoms). Thus, multimodal data fusion benefits a wide range of quantitative medical applications, including personalized patient care, more optimal medical operation plan, and preventive public health. Though there has been extensive research on computational approaches for multimodal fusion, there are three major challenges of multimodal data fusion in quantitative medical applications, which are summarized as feature-level fusion, information-level fusion and knowledge-level fusion: • Feature-level fusion. The first challenge is to mine multimodal biomarkers from high-dimensional small-sample multimodal medical datasets, which hinders the effective discovery of informative multimodal biomarkers. Specifically, efficient dimension reduction algorithms are required to alleviate "curse of dimensionality" problem and address the criteria for discovering interpretable, relevant, non-redundant and generalizable multimodal biomarkers. • Information-level fusion. The second challenge is to exploit and interpret inter-modal and intra-modal information for precise clinical decisions. Although radiomics and multi-branch deep learning have been used for implicit information fusion guided with supervision of the labels, there is a lack of methods to explicitly explore inter-modal relationships in medical applications. Unsupervised multimodal learning is able to mine inter-modal relationship as well as reduce the usage of labor-intensive data and explore potential undiscovered biomarkers; however, mining discriminative information without label supervision is an upcoming challenge. Furthermore, the interpretation of complex non-linear cross-modal associations, especially in deep multimodal learning, is another critical challenge in information-level fusion, which hinders the exploration of multimodal interaction in disease mechanism. • Knowledge-level fusion. The third challenge is quantitative knowledge distillation from multi-focus regions on medical imaging. Although characterizing imaging features from single lesions using either feature engineering or deep learning methods have been investigated in recent years, both methods neglect the importance of inter-region spatial relationships. Thus, a topological profiling tool for multi-focus regions is in high demand, which is yet missing in current feature engineering and deep learning methods. Furthermore, incorporating domain knowledge with distilled knowledge from multi-focus regions is another challenge in knowledge-level fusion. To address the three challenges in multimodal data fusion, this thesis provides a multi-level fusion framework for multimodal biomarker mining, multimodal deep learning, and knowledge distillation from multi-focus regions. Specifically, our major contributions in this thesis include: • To address the challenges in feature-level fusion, we propose an Integrative Multimodal Biomarker Mining framework to select interpretable, relevant, non-redundant and generalizable multimodal biomarkers from high-dimensional small-sample imaging and non-imaging data for diagnostic and prognostic applications. The feature selection criteria including representativeness, robustness, discriminability, and non-redundancy are exploited by consensus clustering, Wilcoxon filter, sequential forward selection, and correlation analysis, respectively. SHapley Additive exPlanations (SHAP) method and nomogram are employed to further enhance feature interpretability in machine learning models. • To address the challenges in information-level fusion, we propose an Interpretable Deep Correlational Fusion framework, based on canonical correlation analysis (CCA) for 1) cohesive multimodal fusion of medical imaging and non-imaging data, and 2) interpretation of complex non-linear cross-modal associations. Specifically, two novel loss functions are proposed to optimize the discovery of informative multimodal representations in both supervised and unsupervised deep learning, by jointly learning inter-modal consensus and intra-modal discriminative information. An interpretation module is proposed to decipher the complex non-linear cross-modal association by leveraging interpretation methods in both deep learning and multimodal consensus learning. • To address the challenges in knowledge-level fusion, we proposed a Dynamic Topological Analysis framework, based on persistent homology, for knowledge distillation from inter-connected multi-focus regions in medical imaging and incorporation of domain knowledge. Different from conventional feature engineering and deep learning, our DTA framework is able to explicitly quantify inter-region topological relationships, including global-level geometric structure and community-level clusters. K-simplex Community Graph is proposed to construct the dynamic community graph for representing community-level multi-scale graph structure. The constructed dynamic graph is subsequently tracked with a novel Decomposed Persistence algorithm. Domain knowledge is incorporated into the Adaptive Community Profile, summarizing the tracked multi-scale community topology with additional customizable clinically important factors

Unsupervised Domain Adaptation for Multispectral Pedestrian Detection

Multimodal information (e.g., visible and thermal) can generate robust pedestrian detections to facilitate around-the-clock computer vision applications, such as autonomous driving and video surveillance. However, it still remains a crucial challenge to train a reliable detector working well in different multispectral pedestrian datasets without manual annotations. In this paper, we propose a novel unsupervised domain adaptation framework for multispectral pedestrian detection, by iteratively generating pseudo annotations and updating the parameters of our designed multispectral pedestrian detector on target domain. Pseudo annotations are generated using the detector trained on source domain, and then updated by fixing the parameters of detector and minimizing the cross entropy loss without back-propagation. Training labels are generated using the pseudo annotations by considering the characteristics of similarity and complementarity between well-aligned visible and infrared image pairs. The parameters of detector are updated using the generated labels by minimizing our defined multi-detection loss function with back-propagation. The optimal parameters of detector can be obtained after iteratively updating the pseudo annotations and parameters. Experimental results show that our proposed unsupervised multimodal domain adaptation method achieves significantly higher detection performance than the approach without domain adaptation, and is competitive with the supervised multispectral pedestrian detectors

Learning Deep Representations of Appearance and Motion for Anomalous Event Detection

We present a novel unsupervised deep learning framework for anomalous event detection in complex video scenes. While most existing works merely use hand-crafted appearance and motion features, we propose Appearance and Motion DeepNet (AMDN) which utilizes deep neural networks to automatically learn feature representations. To exploit the complementary information of both appearance and motion patterns, we introduce a novel double fusion framework, combining both the benefits of traditional early fusion and late fusion strategies. Specifically, stacked denoising autoencoders are proposed to separately learn both appearance and motion features as well as a joint representation (early fusion). Based on the learned representations, multiple one-class SVM models are used to predict the anomaly scores of each input, which are then integrated with a late fusion strategy for final anomaly detection. We evaluate the proposed method on two publicly available video surveillance datasets, showing competitive performance with respect to state of the art approaches.Comment: Oral paper in BMVC 201

Detection-by-Localization: Maintenance-Free Change Object Detector

Recent researches demonstrate that self-localization performance is a very useful measure of likelihood-of-change (LoC) for change detection. In this paper, this "detection-by-localization" scheme is studied in a novel generalized task of object-level change detection. In our framework, a given query image is segmented into object-level subimages (termed "scene parts"), which are then converted to subimage-level pixel-wise LoC maps via the detection-by-localization scheme. Our approach models a self-localization system as a ranking function, outputting a ranked list of reference images, without requiring relevance score. Thanks to this new setting, we can generalize our approach to a broad class of self-localization systems. Our ranking based self-localization model allows to fuse self-localization results from different modalities via an unsupervised rank fusion derived from a field of multi-modal information retrieval (MMR).Comment: 7 pages, 3 figures, Technical repor