20 year evolution of Glyaderm® dermal regeneration matrix:the first non-commercial dermal regeneration matrix

The research of Dr. Pirayesh encompassed a series of carefully planned studies ranging from laboratory research to clinical applications. The goal was to develop and validate Glyaderm® as an effective dermal replacement. Long-term studies have shown that Glyaderm® can be effectively integrated with autologous skin grafting after wound bed preparation, resulting in reduced costs and morbidity.In a prospective, randomized clinical study, the effectiveness of Glyaderm® and autologous skin grafting was confirmed. This combination was found to be non-inferior to standard treatment in terms of graft uptake, scar scales and color. In addition, the two-stage procedure with Glyaderm® showed superior elasticity and better results in visual scar evaluation.Glyaderm® has proven to be an effective choice for burn treatment, with beneficial outcomes and a positive impact on patients' quality of life

Recent Advances in Wound Healing

The human wound-healing process could be divided into four discrete phases, which have also been indicated as the hemostasis, the inflammatory, the proliferation, and the remodeling phase. For a wound to be healed efficaciously, all four phases must sequentially happen at an expected time setting. Numerous aspects can hinder one or more stages of this procedure, thus can cause inappropriate or diminished wound healing. This book reviews the recent literature on the most significant factors that affect wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include physiology of wound healing, interferon, stem cells and photobiomodulation, chronic venous ulcer, chronic fistula, bionanomaterials, topical antiseptic agents, including silver and sodium hypochlorite solution, diabetic ulcers, and nutritional supplements such as copper

Textbook on Scar Management

This text book is open access under a CC BY 4.0 license. Written by a group of international experts in the field and the result of over ten years of collaboration, it allows students and readers to gain to gain a detailed understanding of scar and wound treatment – a topic still dispersed among various disciplines. The content is divided into three parts for easy reference. The first part focuses on the fundamentals of scar management, including assessment and evaluation procedures, classification, tools for accurate measurement of all scar-related elements (volume density, color, vascularization), descriptions of the different evaluation scales. It also features chapters on the best practices in electronic-file storage for clinical reevaluation and telemedicine procedures for safe remote evaluation. The second section offers a comprehensive review of treatment and evidence-based technologies, presenting a consensus of the various available guidelines (silicone, surgery, chemical injections, mechanical tools for scar stabilization, lasers). The third part evaluates the full range of emerging technologies offered to physicians as alternative or complementary solutions for wound healing (mechanical, chemical, anti-proliferation). Textbook on Scar Management will appeal to trainees, fellows, residents and physicians dealing with scar management in plastic surgery, dermatology, surgery and oncology, as well as to nurses and general practitioners ; Comprehensive reference covering the complete field of wounds and scar management: semiology, classifications and scoring Highly educational contents for trainees as well as professionals in plastic surgery, dermatology, surgery, oncology as well as nurses and general practitioners Fast access to information through key points, take home messages, highlights, and a wealth of clinical cases Book didactic contents enhanced by supplementary material and video

Wound Healing

Wound Healing presents recent information and basic knowledge about wound management, including healing mechanisms and actions. It provides a comprehensive overview of the subject, including pathophysiology and clinical and medical management. Chapters cover such topics as negative pressure wound management, hypertrophic scarring, biomaterials derived from plants, insulin use, and modified collagen. This book will help dermatologists, students, surgeons, and physicians who treat patients with wounds

Skin Tissue Models

Skin Tissue Models provides a translational link for biomedical researchers on the interdisciplinary approaches to skin regeneration. As the skin is the largest organ in the body, engineered substitutes have critical medical application to patients with disease and injury - from burn wounds and surgical scars, to vitiligo, psoriasis and even plastic surgery. This volume offers readers preliminary description of the normal structure and function of mammalian skin, exposure to clinical problems and disease, coverage of potential therapeutic molecules and testing, skin substitutes, models as study platforms of skin biology and emerging technologies. The editors have created a table of contents which frames the relevance of skin tissue models for researchers as platforms to study skin biology and therapeutic approaches for different skin diseases, for clinicians as tissue substitutes, and for cosmetic and pharmaceutical industries as alternative test substrates that can replace animal models. Offers descriptions of the normal structure/function of mammalian skin, exposure to clinical problems, and more Presents coverage of skin diseases (cancer, genodermatoses, vitiligo and psoriasis) that extends to clinical requirements and skin diseases in vitro models Addresses legal requirements and ethical concerns in drugs and cosmetics in vitro testing Edited and authored by internationally renowned group of researchers, presenting the broadest coverage possible. © 2018 Elsevier Inc. All rights reserved.(undefined)info:eu-repo/semantics/publishedVersio

Ionospheric correction of interferometric SAR data with application to the cryospheric sciences

Thesis (Ph.D.) University of Alaska Fairbanks, 2018The ionosphere has been identified as an important error source for spaceborne Synthetic Aperture Radar (SAR) data and SAR Interferometry (InSAR), especially for low frequency SAR missions, operating, e.g., at L-band or P-band. Developing effective algorithms for the correction of ionospheric effects is still a developing and active topic of remote sensing research. The focus of this thesis is to develop robust and accurate techniques for ionospheric correction of SAR and InSAR data and evaluate the benefit of these techniques for cryospheric research fields such as glacier ice velocity tracking and permafrost deformation monitoring. As both topics are mostly concerned with high latitude areas where the ionosphere is often active and characterized by turbulence, ionospheric correction is particularly relevant for these applications. After an introduction to the research topic in Chapter 1, Chapter 2 will discuss open issues in ionospheric correction including processing issues related to baseline-induced spectrum shifts. The effect of large baseline on split spectrum InSAR technique has been thoroughly evaluated and effective solutions for compensating this effect are proposed. In addition, a multiple sub-band approach is proposed for increasing the algorithm robustness and accuracy. Selected case studies are shown with the purpose of demonstrating the performance of the developed algorithm. In Chapter 3, the developed ionospheric correction technology is applied to optimize InSAR-based ice velocity measurements over the big ice sheets in Greenland and the Antarctic. Selected case studies are presented to demonstrate and validate the effectiveness of the proposed correction algorithms for ice velocity applications. It is shown that the ionosphere signal can be larger than the actual glacier motion signal in the interior of Greenland and Antarctic, emphasizing the necessity for operational ionospheric correction. The case studies also show that the accuracy of ice velocity estimates was significantly improved once the developed ionospheric correction techniques were integrated into the data processing flow. We demonstrate that the proposed ionosphere correction outperforms the traditionally-used approaches such as the averaging of multi-temporal data and the removal of obviously affected data sets. For instance, it is shown that about one hundred multi-temporal ice velocity estimates would need to be averaged to achieve the estimation accuracy of a single ionosphere-corrected measurement. In Chapter 4, we evaluate the necessity and benefit of ionospheric-correction for L-band InSAR-based permafrost research. In permafrost zones, InSAR-based surface deformation measurements are used together with geophysical models to estimate permafrost parameters such as active layer thickness, soil ice content, and permafrost degradation. Accurate error correction is needed to avoid biases in the estimated parameters and their co-variance properties. Through statistical analyses of a large number of L-band InSAR data sets over Alaska, we show that ionospheric signal distortions, at different levels of magnitude, are present in almost every InSAR dataset acquired in permafrost-affected regions. We analyze the ionospheric correction performance that can be achieved in permafrost zones by statistically analyzing correction results for large number of InSAR data. We also investigate the impact of ionospheric correction on the performance of the two main InSAR approaches that are used in permafrost zones: (1) we show the importance of ionospheric correction for permafrost deformation estimation from discrete InSAR observations; (2) we demonstrate that ionospheric correction leads to significant improvements in the accuracy of time-series InSAR-based permafrost products. Chapter 5 summarizes the work conducted in this dissertation and proposes next steps in this field of research

Textbook on Scar Management

This text book is open access under a CC BY 4.0 license. Written by a group of international experts in the field and the result of over ten years of collaboration, it allows students and readers to gain to gain a detailed understanding of scar and wound treatment – a topic still dispersed among various disciplines. The content is divided into three parts for easy reference. The first part focuses on the fundamentals of scar management, including assessment and evaluation procedures, classification, tools for accurate measurement of all scar-related elements (volume density, color, vascularization), descriptions of the different evaluation scales. It also features chapters on the best practices in electronic-file storage for clinical reevaluation and telemedicine procedures for safe remote evaluation. The second section offers a comprehensive review of treatment and evidence-based technologies, presenting a consensus of the various available guidelines (silicone, surgery, chemical injections, mechanical tools for scar stabilization, lasers). The third part evaluates the full range of emerging technologies offered to physicians as alternative or complementary solutions for wound healing (mechanical, chemical, anti-proliferation). Textbook on Scar Management will appeal to trainees, fellows, residents and physicians dealing with scar management in plastic surgery, dermatology, surgery and oncology, as well as to nurses and general practitioners ; Comprehensive reference covering the complete field of wounds and scar management: semiology, classifications and scoring Highly educational contents for trainees as well as professionals in plastic surgery, dermatology, surgery, oncology as well as nurses and general practitioners Fast access to information through key points, take home messages, highlights, and a wealth of clinical cases Book didactic contents enhanced by supplementary material and video

Bionanotechnology to Save the Environment

Nanotechnology is the science of manipulating atoms and molecules in the nanoscale thousand times smaller than the width of a human hair. The world market for products that contain nanomaterials is expected to increase enormously in the future. The use of nanotechnology has stretched across various streams of science, from electronics to medicine and has also found applications in the field of cosmetics. How will this revolution impact our lifestyle and our planet? Very often the progresses of science, human knowledge and evolution of our lifestyle has been associated with devastating effects on our forests, oceans and more in general on our planet. The real challenge in the years to come is the sustainability of human evolution. The reader of this interesting book will discover how nanotechnology, and in particular nanomaterials derived from plant biomass and fishery’s waste, can improve the quality of our environment by reducing carbon emissions, improving the recycling of materials and even, in the long run, became a profitable business. Green nanotechnologies can be applied to a huge number of products ranging from intelligent textiles to smart drugs or functional polymers which can have a big impact on our daily lives, but nevertheless help us in saving our biodiversity and our planet. However, to fully achieve all these benefits, companies and scientists should be supported by National and International Agencies and Institutions in order to facilitate and support scientific development in this field allowing from one side the protection of intellectual property, but on the other giving accessibility of these technologies to emerging countries for improving the quality of life and the environment all over the world equally