A modular hybrid simulation framework for complex manufacturing system design

For complex manufacturing systems, the current hybrid Agent-Based Modelling and Discrete Event Simulation (ABM–DES) frameworks are limited to component and system levels of representation and present a degree of static complexity to study optimal resource planning. To address these limitations, a modular hybrid simulation framework for complex manufacturing system design is presented. A manufacturing system with highly regulated and manual handling processes, composed of multiple repeating modules, is considered. In this framework, the concept of modular hybrid ABM–DES technique is introduced to demonstrate a novel simulation method using a dynamic system of parallel multi-agent discrete events. In this context, to create a modular model, the stochastic finite dynamical system is extended to allow the description of discrete event states inside the agent for manufacturing repeating modules (meso level). Moreover, dynamic complexity regarding uncertain processing time and resources is considered. This framework guides the user step-by-step through the system design and modular hybrid model. A real case study in the cell and gene therapy industry is conducted to test the validity of the framework. The simulation results are compared against the data from the studied case; excellent agreement with 1.038% error margin is found in terms of the company performance. The optimal resource planning and the uncertainty of the processing time for manufacturing phases (exo level), in the presence of dynamic complexity is calculated

Discrete Event Simulation Modelling for Dynamic Decision Making in Biopharmaceutical Manufacturing

With the increase in demand for biopharmaceutical products, industries have realised the need to scale up their manufacturing from laboratory-based processes to financially viable production processes. In this context, biopharmaceutical manufacturers are increasingly using simulation-based approaches to gain transparency of their current production system and to assist with designing improved systems. This paper discusses the application of Discrete Event Simulation (DES) and its ability to model the various scenarios for dynamic decision making in biopharmaceutical manufacturing sector. This paper further illustrates a methodology used to develop a simulation model for a biopharmaceutical company, which is considering several capital investments to improve its manufacturing processes. A simulation model for a subset of manufacturing activities was developed that facilitated ‘what-if’ scenario planning for a proposed process alternative. The simulation model of the proposed manufacturing process has shown significant improvement over the current process in terms of throughout time reduction, better resource utilisation, operating cost reduction, reduced bottlenecks etc. This visibility of the existing and proposed production system assisted the company in identifying the potential capital and efficiency gains from the investments therefore demonstrating that DES can be an effective tool for making more informed decisions. Furthermore, the paper also discusses the utilisation of DES models to develop a number of bespoke productivity improvement tools for the company

Semiconductor manufacturing simulation design and analysis with limited data

This paper discusses simulation design and analysis for Silicon Carbide (SiC) manufacturing operations management at New York Power Electronics Manufacturing Consortium (PEMC) facility. Prior work has addressed the development of manufacturing system simulation as the decision support to solve the strategic equipment portfolio selection problem for the SiC fab design [1]. As we move into the phase of collecting data from the equipment purchased for the PEMC facility, we discuss how to redesign our manufacturing simulations and analyze their outputs to overcome the challenges that naturally arise in the presence of limited fab data. We conclude with insights on how an approach aimed to reflect learning from data can enable our discrete-event stochastic simulation to accurately estimate the performance measures for SiC manufacturing at the PEMC facility

A lean assessment tool based on systems dynamics

Lean manufacturing is synonymous with a set of practices used in the identification and elimination of waste related with the manufacturing system, and focusing on what creates value for the customer. Lean assessment tools enable an overall audit of the performance of lean practices, and so are able to identify lean improvements. The interactions between lean practices and their improvements are often latent and need to be investigated: a systems approach can be used to disclose these hidden interactions. In this article, system dynamics is used as a lean assessment tool to assess and improve lean performance for a print packaging manufacturing system

Pathophysiology, histopathology and therapeutic of SARS-CoV-2

The rapid transmission of SARS-CoV-2 through the world has induced the scientist to understand the histopathology of the virus and then to find an effective drug. However, many of the point associated with the virus pathogenicity still unknown and need more studies. In this chapter the pathophysiology, histopathology and therapeutic of SARS-CoV-2 has been reviewed. It was appeared that pathogenicity of SARS-CoV-2 is belonging to the viral with genome structure which acting by blocking the host innate immune response. Both chloroquine and hydroxyl-chloroquine have similar structure and mechanism action and they are among the most effective antiviral for treating the patents with the SARS-CoV-2. Chloroquine works by inhibition the intracellular organism by increasing the pH

Aerospace Manufacturing Industry: A Simulation-Based Decision Support Framework for the Scheduling of Complex Hoist Lines

The hoist scheduling problem is a critical issue in the design and control of Automated Manufacturing Systems. To deal with the major complexities appearing in such problem, this work introduces an advanced simulation model to represent the short-term scheduling of complex hoist lines. The aim is to find the best jobs schedule that minimizing the makespan while maximizing throughput with no defective outputs. Several hard constraints are considered in the model: single shared hoist, heterogeneous recipes, eventual recycles flows, and no buffers between workstations. Different heuristic-based strategies are incorporated into the computer model in order to improve the solutions generated over time. The alternative solutions can be quickly evaluated by using a graphical user interface developed together with the simulation model.Fil: Basán, Natalia Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Pulido, Raul. Universidad Politécnica de Madrid; EspañaFil: Coccola, Mariana Evangelina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; ArgentinaFil: Mendez, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

Digital implementation of the cellular sensor-computers

Two different kinds of cellular sensor-processor architectures are used nowadays in various applications. The first is the traditional sensor-processor architecture, where the sensor and the processor arrays are mapped into each other. The second is the foveal architecture, in which a small active fovea is navigating in a large sensor array. This second architecture is introduced and compared here. Both of these architectures can be implemented with analog and digital processor arrays. The efficiency of the different implementation types, depending on the used CMOS technology, is analyzed. It turned out, that the finer the technology is, the better to use digital implementation rather than analog

A Touch of Evil: High-Assurance Cryptographic Hardware from Untrusted Components

The semiconductor industry is fully globalized and integrated circuits (ICs) are commonly defined, designed and fabricated in different premises across the world. This reduces production costs, but also exposes ICs to supply chain attacks, where insiders introduce malicious circuitry into the final products. Additionally, despite extensive post-fabrication testing, it is not uncommon for ICs with subtle fabrication errors to make it into production systems. While many systems may be able to tolerate a few byzantine components, this is not the case for cryptographic hardware, storing and computing on confidential data. For this reason, many error and backdoor detection techniques have been proposed over the years. So far all attempts have been either quickly circumvented, or come with unrealistically high manufacturing costs and complexity. This paper proposes Myst, a practical high-assurance architecture, that uses commercial off-the-shelf (COTS) hardware, and provides strong security guarantees, even in the presence of multiple malicious or faulty components. The key idea is to combine protective-redundancy with modern threshold cryptographic techniques to build a system tolerant to hardware trojans and errors. To evaluate our design, we build a Hardware Security Module that provides the highest level of assurance possible with COTS components. Specifically, we employ more than a hundred COTS secure crypto-coprocessors, verified to FIPS140-2 Level 4 tamper-resistance standards, and use them to realize high-confidentiality random number generation, key derivation, public key decryption and signing. Our experiments show a reasonable computational overhead (less than 1% for both Decryption and Signing) and an exponential increase in backdoor-tolerance as more ICs are added

Effective use of product quality information in meat processing

This paper presents a case study on use of advanced product quality information in meat processing. To serve segmented customer demand meat processors consider use of innovative sensor technology to sort meat products to customer orders. To assess the use of this sensor technology a discrete-event simulation model is built. Various scenarios were defined for processing strategy (buffered or non-buffered), the number of end product groups to sort to and the availability of product quality information. The performance of these scenarios is measured w.r.t. order compliance, labor consumption and throughput-time. Our results reveal that the current processing and product sorting strategy is in-effective for sorting to a large number of end product groups. Furthermore, the current availability of product quality information is insufficient to ensure high levels of order compliance for advanced product quality products

A survey of health care models that encompass multiple departments

In this survey we review quantitative health care models to illustrate the extent to which they encompass multiple hospital departments. The paper provides general overviews of the relationships that exists between major hospital departments and describes how these relationships are accounted for by researchers. We find the atomistic view of hospitals often taken by researchers is partially due to the ambiguity of patient care trajectories. To this end clinical pathways literature is reviewed to illustrate its potential for clarifying patient flows and for providing a holistic hospital perspective