43,097 research outputs found
Graph analysis of functional brain networks: practical issues in translational neuroscience
The brain can be regarded as a network: a connected system where nodes, or
units, represent different specialized regions and links, or connections,
represent communication pathways. From a functional perspective communication
is coded by temporal dependence between the activities of different brain
areas. In the last decade, the abstract representation of the brain as a graph
has allowed to visualize functional brain networks and describe their
non-trivial topological properties in a compact and objective way. Nowadays,
the use of graph analysis in translational neuroscience has become essential to
quantify brain dysfunctions in terms of aberrant reconfiguration of functional
brain networks. Despite its evident impact, graph analysis of functional brain
networks is not a simple toolbox that can be blindly applied to brain signals.
On the one hand, it requires a know-how of all the methodological steps of the
processing pipeline that manipulates the input brain signals and extract the
functional network properties. On the other hand, a knowledge of the neural
phenomenon under study is required to perform physiological-relevant analysis.
The aim of this review is to provide practical indications to make sense of
brain network analysis and contrast counterproductive attitudes
User-centered visual analysis using a hybrid reasoning architecture for intensive care units
One problem pertaining to Intensive Care Unit information systems is that, in some cases, a very dense display of data can result. To ensure the overview and readability of the increasing volumes of data, some special features are required (e.g., data prioritization, clustering, and selection mechanisms) with the application of analytical methods (e.g., temporal data abstraction, principal component analysis, and detection of events). This paper addresses the problem of improving the integration of the visual and analytical methods applied to medical monitoring systems. We present a knowledge- and machine learning-based approach to support the knowledge discovery process with appropriate analytical and visual methods. Its potential benefit to the development of user interfaces for intelligent monitors that can assist with the detection and explanation of new, potentially threatening medical events. The proposed hybrid reasoning architecture provides an interactive graphical user interface to adjust the parameters of the analytical methods based on the users' task at hand. The action sequences performed on the graphical user interface by the user are consolidated in a dynamic knowledge base with specific hybrid reasoning that integrates symbolic and connectionist approaches. These sequences of expert knowledge acquisition can be very efficient for making easier knowledge emergence during a similar experience and positively impact the monitoring of critical situations. The provided graphical user interface incorporating a user-centered visual analysis is exploited to facilitate the natural and effective representation of clinical information for patient care
Compositional Falsification of Cyber-Physical Systems with Machine Learning Components
Cyber-physical systems (CPS), such as automotive systems, are starting to
include sophisticated machine learning (ML) components. Their correctness,
therefore, depends on properties of the inner ML modules. While learning
algorithms aim to generalize from examples, they are only as good as the
examples provided, and recent efforts have shown that they can produce
inconsistent output under small adversarial perturbations. This raises the
question: can the output from learning components can lead to a failure of the
entire CPS? In this work, we address this question by formulating it as a
problem of falsifying signal temporal logic (STL) specifications for CPS with
ML components. We propose a compositional falsification framework where a
temporal logic falsifier and a machine learning analyzer cooperate with the aim
of finding falsifying executions of the considered model. The efficacy of the
proposed technique is shown on an automatic emergency braking system model with
a perception component based on deep neural networks
MITK-ModelFit: A generic open-source framework for model fits and their exploration in medical imaging -- design, implementation and application on the example of DCE-MRI
Many medical imaging techniques utilize fitting approaches for quantitative
parameter estimation and analysis. Common examples are pharmacokinetic modeling
in DCE MRI/CT, ADC calculations and IVIM modeling in diffusion-weighted MRI and
Z-spectra analysis in chemical exchange saturation transfer MRI. Most available
software tools are limited to a special purpose and do not allow for own
developments and extensions. Furthermore, they are mostly designed as
stand-alone solutions using external frameworks and thus cannot be easily
incorporated natively in the analysis workflow. We present a framework for
medical image fitting tasks that is included in MITK, following a rigorous
open-source, well-integrated and operating system independent policy. Software
engineering-wise, the local models, the fitting infrastructure and the results
representation are abstracted and thus can be easily adapted to any model
fitting task on image data, independent of image modality or model. Several
ready-to-use libraries for model fitting and use-cases, including fit
evaluation and visualization, were implemented. Their embedding into MITK
allows for easy data loading, pre- and post-processing and thus a natural
inclusion of model fitting into an overarching workflow. As an example, we
present a comprehensive set of plug-ins for the analysis of DCE MRI data, which
we validated on existing and novel digital phantoms, yielding competitive
deviations between fit and ground truth. Providing a very flexible environment,
our software mainly addresses developers of medical imaging software that
includes model fitting algorithms and tools. Additionally, the framework is of
high interest to users in the domain of perfusion MRI, as it offers
feature-rich, freely available, validated tools to perform pharmacokinetic
analysis on DCE MRI data, with both interactive and automatized batch
processing workflows.Comment: 31 pages, 11 figures URL: http://mitk.org/wiki/MITK-ModelFi
Statistical Model Checking : An Overview
Quantitative properties of stochastic systems are usually specified in logics
that allow one to compare the measure of executions satisfying certain temporal
properties with thresholds. The model checking problem for stochastic systems
with respect to such logics is typically solved by a numerical approach that
iteratively computes (or approximates) the exact measure of paths satisfying
relevant subformulas; the algorithms themselves depend on the class of systems
being analyzed as well as the logic used for specifying the properties. Another
approach to solve the model checking problem is to \emph{simulate} the system
for finitely many runs, and use \emph{hypothesis testing} to infer whether the
samples provide a \emph{statistical} evidence for the satisfaction or violation
of the specification. In this short paper, we survey the statistical approach,
and outline its main advantages in terms of efficiency, uniformity, and
simplicity.Comment: non
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