Analytical Applications of Bioluminescence and Chemiluminescence

Bioluminescence and chemiluminescence studies were used to measure the amount of adenosine triphosphate and therefore the amount of energy available. Firefly luciferase - luciferin enzyme system was emphasized. Photometer designs are also considered

Optimal modelling and experimentation for the improved sustainability of microfluidic chemical technology design

Optimization of the dynamics and control of chemical processes holds the promise of improved sustainability for chemical technology by minimizing resource wastage. Anecdotally, chemical plant may be substantially over designed, say by 35-50%, due to designers taking account of uncertainties by providing greater flexibility. Once the plant is commissioned, techniques of nonlinear dynamics analysis can be used by process systems engineers to recoup some of this overdesign by optimization of the plant operation through tighter control. At the design stage, coupling the experimentation with data assimilation into the model, whilst using the partially informed, semi-empirical model to predict from parametric sensitivity studies which experiments to run should optimally improve the model. This approach has been demonstrated for optimal experimentation, but limited to a differential algebraic model of the process. Typically, such models for online monitoring have been limited to low dimensions. Recently it has been demonstrated that inverse methods such as data assimilation can be applied to PDE systems with algebraic constraints, a substantially more complicated parameter estimation using finite element multiphysics modelling. Parametric sensitivity can be used from such semi-empirical models to predict the optimum placement of sensors to be used to collect data that optimally informs the model for a microfluidic sensor system. This coupled optimum modelling and experiment procedure is ambitious in the scale of the modelling problem, as well as in the scale of the application - a microfluidic device. In general, microfluidic devices are sufficiently easy to fabricate, control, and monitor that they form an ideal platform for developing high dimensional spatio-temporal models for simultaneously coupling with experimentation. As chemical microreactors already promise low raw materials wastage through tight control of reagent contacting, improved design techniques should be able to augment optimal control systems to achieve very low resource wastage. In this paper, we discuss how the paradigm for optimal modelling and experimentation should be developed and foreshadow the exploitation of this methodology for the development of chemical microreactors and microfluidic sensors for online monitoring of chemical processes. Improvement in both of these areas bodes to improve the sustainability of chemical processes through innovative technology. (C) 2008 The Institution of Chemical Engineers. Published by Elsevier B.V. All rights reserved

On-line health monitoring of passive electronic components using digitally controlled power converter

This thesis presents System Identification based On-Line Health Monitoring to analyse the dynamic behaviour of the Switch-Mode Power Converter (SMPC), detect, and diagnose anomalies in passive electronic components. The anomaly detection in this research is determined by examining the change in passive component values due to degradation. Degradation, which is a long-term process, however, is characterised by inserting different component values in the power converter. The novel health-monitoring capability enables accurate detection of passive electronic components despite component variations and uncertainties and is valid for different topologies of the switch-mode power converter. The need for a novel on-line health-monitoring capability is driven by the need to improve unscheduled in-service, logistics, and engineering costs, including the requirement of Integrated Vehicle Health Management (IVHM) for electronic systems and components. The detection and diagnosis of degradations and failures within power converters is of great importance for aircraft electronic manufacturers, such as Thales, where component failures result in equipment downtime and large maintenance costs. The fact that existing techniques, including built-in-self test, use of dedicated sensors, physics-of-failure, and data-driven based health-monitoring, have yet to deliver extensive application in IVHM, provides the motivation for this research ... [cont.]

Parameter Variation Sensing and Estimation in Nanoscale Fabrics

Parameter variations introduced by manufacturing imprecision are becoming more influential on circuit performance. This is especially the case in emerging nanoscale fabrics due to unconventional manufacturing steps (e.g., nano-imprint) and aggressive scaling. These parameter variations can lead to performance deterioration and consequently yield loss. Parameter variations are typically addressed pre-fabrication with circuit design targeting worst-case timing scenarios. However, this approach is pessimistic and much of performance benefits can be lost. By contrast, if parameter variations can be estimated post-manufacturing, adaptive techniques or reconfiguration could be used to provide more optimal level of tolerance. To estimate parameter variations during run-time, on-chip variation sensors are gaining in importance because of their easy implementation. In this thesis, we propose novel on-chip variation sensors to estimate variations in physical parameters for emerging nanoscale fabrics. Based on the characteristics of systematic and random variations, two separate sensors are designed to estimate the extent of systematic variations and the statistical distribution of random variations from measured fall and rise times in the sensors respectively. The proposed sensor designs are evaluated through HSPICE Monte Carlo simulations with known variation cases injected. Simulation results show that the estimation error of the systematic-variation sensor is less than 1.2% for all simulated cases; and for the random-variation sensor, the worst-case estimation error is 12.7% and the average estimation error is 8% for all simulations. In addition, to address the placement of on-chip sensors, we calculate sensor area and the effective range of systematic-variation sensor. Then using a processor designed in nanoscale fabrics as a target, an example for sensor placement is introduced. Based on the sensor placement, external noises that may affect the measured fall and rise times of outputs are identified. Through careful analysis, we find that these noises do not deteriorate the accuracy of the systematic-variation sensor, but affect the accuracy of the random-variation sensor. We believe that the proposed on-chip variation sensors in conjunction with post-fabrication compensation techniques would be able to improve system-level performance in nanoscale fabrics, which may be an efficient alternative to making worst-case assumptions on parameter variations in nanoscale designs

Introduction to TIPS: a theory for creative design

A highly intriguing problem in combining artificial intelligence and engineering design is automation of the creative and innovative phases of the design process. This paper gives a brief introduction to the theory of inventive problem solving (TIPS) selected as a theoretical basis of the authors' research efforts in this field. The research is conducted in the Stevin Project of the Knowledge-Based System Group of the University of Twente (Enschede, The Netherlands) in cooperation with the Invention Machine Laboratory (Minsk, Belarus). This collaboration aims at developing a formal basis for the creation of an automated reasoning system to support creative engineering design