162,969 research outputs found
A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale
In this era of complete genomes, our knowledge of neuroanatomical circuitry
remains surprisingly sparse. Such knowledge is however critical both for basic
and clinical research into brain function. Here we advocate for a concerted
effort to fill this gap, through systematic, experimental mapping of neural
circuits at a mesoscopic scale of resolution suitable for comprehensive,
brain-wide coverage, using injections of tracers or viral vectors. We detail
the scientific and medical rationale and briefly review existing knowledge and
experimental techniques. We define a set of desiderata, including brain-wide
coverage; validated and extensible experimental techniques suitable for
standardization and automation; centralized, open access data repository;
compatibility with existing resources, and tractability with current
informatics technology. We discuss a hypothetical but tractable plan for mouse,
additional efforts for the macaque, and technique development for human. We
estimate that the mouse connectivity project could be completed within five
years with a comparatively modest budget.Comment: 41 page
Space biology initiative program definition review. Trade study 6: Space Station Freedom/spacelab modules compatibility
The differences in rack requirements for Spacelab, the Shuttle Orbiter, and the United States (U.S.) laboratory module, European Space Agency (ESA) Columbus module, and the Japanese Experiment Module (JEM) of Space Station Freedom are identified. The feasibility of designing standardized mechanical, structural, electrical, data, video, thermal, and fluid interfaces to allow space flight hardware designed for use in the U.S. laboratory module to be used in other locations is assessed
Towards a methodical framework for comprehensively assessing forest multifunctionality
Funded by Deutsche Forschungsgemeinschaft. Grant Number: DFG FOR 891/1-3 National Natural Science Foundation of China. Grant Numbers: 30710103907, 30930005, 31170457, 31210103910 Swiss National Science Foundation (SNSF) Sino-German Centre for Research Promotion in Beijing. Grant Number: GZ 986Peer reviewedPublisher PD
Quantifying the impact of weak, strong, and super ties in scientific careers
Scientists are frequently faced with the important decision to start or
terminate a creative partnership. This process can be influenced by strategic
motivations, as early career researchers are pursuers, whereas senior
researchers are typically attractors, of new collaborative opportunities.
Focusing on the longitudinal aspects of scientific collaboration, we analyzed
473 collaboration profiles using an ego-centric perspective which accounts for
researcher-specific characteristics and provides insight into a range of
topics, from career achievement and sustainability to team dynamics and
efficiency. From more than 166,000 collaboration records, we quantify the
frequency distributions of collaboration duration and tie-strength, showing
that collaboration networks are dominated by weak ties characterized by high
turnover rates. We use analytic extreme-value thresholds to identify a new
class of indispensable `super ties', the strongest of which commonly exhibit
>50% publication overlap with the central scientist. The prevalence of super
ties suggests that they arise from career strategies based upon cost, risk, and
reward sharing and complementary skill matching. We then use a combination of
descriptive and panel regression methods to compare the subset of publications
coauthored with a super tie to the subset without one, controlling for
pertinent features such as career age, prestige, team size, and prior group
experience. We find that super ties contribute to above-average productivity
and a 17% citation increase per publication, thus identifying these
partnerships - the analog of life partners - as a major factor in science
career development.Comment: 13 pages, 5 figures, 1 Tabl
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