Cervical Auscultation for the Identification of Swallowing Difficulties

Swallowing difficulties, commonly referred to as dysphagia, affect thousands of Americans every year. They have a multitude of causes, but in general they are known to increase the risk of aspiration when swallowing in addition to other physiological effects. Cervical auscultation has been recently applied to detect such difficulties non-invasively and various techniques for analysis and processing of the recorded signals have been proposed. We attempted to further this research in three key areas. First, we characterized swallows with regards to a multitude of time, frequency, and time-frequency features while paying special attention to the differences between swallows from healthy adults and safe dysphagic swallows as well as safe and unsafe dysphagic swallows. Second, we attempted to utilize deep belief networks in order to classify these states automatically and without the aid of a concurrent videofluoroscopic examination. Finally, we sought to improve some of the signal processing techniques used in this field. We both implemented the DBSCAN algorithm to better segment our physiological signals as well as applied the matched complex wavelet transform to cervical auscultation data in order to improve its quality for mathematical analysis

Noninvasive Dynamic Characterization of Swallowing Kinematics and Impairments in High Resolution Cervical Auscultation via Deep Learning

Swallowing is a complex sensorimotor activity by which food and liquids are transferred from the oral cavity to the stomach. Swallowing requires the coordination between multiple subsystems which makes it subject to impairment secondary to a variety of medical or surgically related conditions. Dysphagia refers to any swallowing disorder and is common in patients with head and neck cancer and neurological conditions such as stroke. Dysphagia affects nearly 9 million adults and causes death for more than 60,000 yearly in the US. In this research, we utilize advanced signal processing techniques with sensor technology and deep learning methods to develop a noninvasive and widely available tool for the evaluation and diagnosis of swallowing problems. We investigate the use of modern spectral estimation methods in addition to convolutional recurrent neural networks to demarcate and localize the important swallowing physiological events that contribute to airway protection solely based on signals collected from non-invasive sensors attached to the anterior neck. These events include the full swallowing activity, upper esophageal sphincter opening duration and maximal opening diameter, and aspiration. We believe that combining sensor technology and state of the art deep learning architectures specialized in time series analysis, will help achieve great advances for dysphagia detection and management in terms of non-invasiveness, portability, and availability. Like never before, such advances will enable patients to get continuous feedback about their swallowing out of standard clinical care setting which will extremely facilitate their daily activities and enhance the quality of their lives

Characterizing oropharyngeal swallowing following single lung transplantation in adults

Swallowing is a physiologically complex kinematic process during which abnormal obstruction of bolus flow of incoordination can occur. Dysphagia, or a difficulty with swallowing, is a concern following single-lung transplantation (SLT) due to the high risk of recurrent laryngeal nerve damage, upper airway trauma secondary to orotracheal intubation, disruption of pulmonary sensorimotor circuits responsible for airway penetration, and the required levels of immunosuppression during and following surgery. Post-operatively, repetitive aspiration events are a major contributing factor in the long-term failure of lung allograft function. The goal of this descriptive, retrospective study is to quantitatively describe the characteristics of swallowing kinematic function through six durational measures in a group of 10 patients (age 49-68) following single-lung transplantation, describe airway protection ordinally through penetration-aspiration scale scores, and to compare findings from these patients to published norms for healthy adults. By explicitly describing the swallow physiology of a sample of patients with SLTs, clinically significant risk factors will be identified to help researchers and clinicians consider better treatment and safe swallowing strategies for future patients in order to mitigate adverse post-operative events, effectively increasing the functional lifespan of the transplant organ, and thusly decreasing morbidity and patient mortality

The 2nd International Electronic Conference on Applied Sciences

This book is focused on the works presented at the 2nd International Electronic Conference on Applied Sciences, organized by Applied Sciences from 15 to 31 October 2021 on the MDPI Sciforum platform. Two decades have passed since the start of the 21st century. The development of sciences and technologies is growing ever faster today than in the previous century. The field of science is expanding, and the structure of science is becoming ever richer. Because of this expansion and fine structure growth, researchers may lose themselves in the deep forest of the ever-increasing frontiers and sub-fields being created. This international conference on the Applied Sciences was started to help scientists conduct their own research into the growth of these frontiers by breaking down barriers and connecting the many sub-fields to cut through this vast forest. These functions will allow researchers to see these frontiers and their surrounding (or quite distant) fields and sub-fields, and give them the opportunity to incubate and develop their knowledge even further with the aid of this multi-dimensional network

Investigating the build-up of precedence effect using reflection masking

The auditory processing level involved in the build‐up of precedence [Freyman et al., J. Acoust. Soc. Am. 90, 874–884 (1991)] has been investigated here by employing reflection masked threshold (RMT) techniques. Given that RMT techniques are generally assumed to address lower levels of the auditory signal processing, such an approach represents a bottom‐up approach to the buildup of precedence. Three conditioner configurations measuring a possible buildup of reflection suppression were compared to the baseline RMT for four reflection delays ranging from 2.5–15 ms. No buildup of reflection suppression was observed for any of the conditioner configurations. Buildup of template (decrease in RMT for two of the conditioners), on the other hand, was found to be delay dependent. For five of six listeners, with reflection delay=2.5 and 15 ms, RMT decreased relative to the baseline. For 5‐ and 10‐ms delay, no change in threshold was observed. It is concluded that the low‐level auditory processing involved in RMT is not sufficient to realize a buildup of reflection suppression. This confirms suggestions that higher level processing is involved in PE buildup. The observed enhancement of reflection detection (RMT) may contribute to active suppression at higher processing levels