9,186 research outputs found

    Topological network alignment uncovers biological function and phylogeny

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    Sequence comparison and alignment has had an enormous impact on our understanding of evolution, biology, and disease. Comparison and alignment of biological networks will likely have a similar impact. Existing network alignments use information external to the networks, such as sequence, because no good algorithm for purely topological alignment has yet been devised. In this paper, we present a novel algorithm based solely on network topology, that can be used to align any two networks. We apply it to biological networks to produce by far the most complete topological alignments of biological networks to date. We demonstrate that both species phylogeny and detailed biological function of individual proteins can be extracted from our alignments. Topology-based alignments have the potential to provide a completely new, independent source of phylogenetic information. Our alignment of the protein-protein interaction networks of two very different species--yeast and human--indicate that even distant species share a surprising amount of network topology with each other, suggesting broad similarities in internal cellular wiring across all life on Earth.Comment: Algorithm explained in more details. Additional analysis adde

    XML Matchers: approaches and challenges

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    Schema Matching, i.e. the process of discovering semantic correspondences between concepts adopted in different data source schemas, has been a key topic in Database and Artificial Intelligence research areas for many years. In the past, it was largely investigated especially for classical database models (e.g., E/R schemas, relational databases, etc.). However, in the latest years, the widespread adoption of XML in the most disparate application fields pushed a growing number of researchers to design XML-specific Schema Matching approaches, called XML Matchers, aiming at finding semantic matchings between concepts defined in DTDs and XSDs. XML Matchers do not just take well-known techniques originally designed for other data models and apply them on DTDs/XSDs, but they exploit specific XML features (e.g., the hierarchical structure of a DTD/XSD) to improve the performance of the Schema Matching process. The design of XML Matchers is currently a well-established research area. The main goal of this paper is to provide a detailed description and classification of XML Matchers. We first describe to what extent the specificities of DTDs/XSDs impact on the Schema Matching task. Then we introduce a template, called XML Matcher Template, that describes the main components of an XML Matcher, their role and behavior. We illustrate how each of these components has been implemented in some popular XML Matchers. We consider our XML Matcher Template as the baseline for objectively comparing approaches that, at first glance, might appear as unrelated. The introduction of this template can be useful in the design of future XML Matchers. Finally, we analyze commercial tools implementing XML Matchers and introduce two challenging issues strictly related to this topic, namely XML source clustering and uncertainty management in XML Matchers.Comment: 34 pages, 8 tables, 7 figure

    Inferring gene ontologies from pairwise similarity data.

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    MotivationWhile the manually curated Gene Ontology (GO) is widely used, inferring a GO directly from -omics data is a compelling new problem. Recognizing that ontologies are a directed acyclic graph (DAG) of terms and hierarchical relations, algorithms are needed that: analyze a full matrix of gene-gene pairwise similarities from -omics data; infer true hierarchical structure in these data rather than enforcing hierarchy as a computational artifact; and respect biological pleiotropy, by which a term in the hierarchy can relate to multiple higher level terms. Methods addressing these requirements are just beginning to emerge-none has been evaluated for GO inference.MethodsWe consider two algorithms [Clique Extracted Ontology (CliXO), LocalFitness] that uniquely satisfy these requirements, compared with methods including standard clustering. CliXO is a new approach that finds maximal cliques in a network induced by progressive thresholding of a similarity matrix. We evaluate each method's ability to reconstruct the GO biological process ontology from a similarity matrix based on (a) semantic similarities for GO itself or (b) three -omics datasets for yeast.ResultsFor task (a) using semantic similarity, CliXO accurately reconstructs GO (>99% precision, recall) and outperforms other approaches (<20% precision, <20% recall). For task (b) using -omics data, CliXO outperforms other methods using two -omics datasets and achieves āˆ¼30% precision and recall using YeastNet v3, similar to an earlier approach (Network Extracted Ontology) and better than LocalFitness or standard clustering (20-25% precision, recall).ConclusionThis study provides algorithmic foundation for building gene ontologies by capturing hierarchical and pleiotropic structure embedded in biomolecular data

    A Large Scale Dataset for the Evaluation of Ontology Matching Systems

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    Recently, the number of ontology matching techniques and systems has increased significantly. This makes the issue of their evaluation and comparison more severe. One of the challenges of the ontology matching evaluation is in building large scale evaluation datasets. In fact, the number of possible correspondences between two ontologies grows quadratically with respect to the numbers of entities in these ontologies. This often makes the manual construction of the evaluation datasets demanding to the point of being infeasible for large scale matching tasks. In this paper we present an ontology matching evaluation dataset composed of thousands of matching tasks, called TaxME2. It was built semi-automatically out of the Google, Yahoo and Looksmart web directories. We evaluated TaxME2 by exploiting the results of almost two dozen of state of the art ontology matching systems. The experiments indicate that the dataset possesses the desired key properties, namely it is error-free, incremental, discriminative, monotonic, and hard for the state of the art ontology matching systems. The paper has been accepted for publication in "The Knowledge Engineering Review", Cambridge Universty Press (ISSN: 0269-8889, EISSN: 1469-8005)

    Global Network Alignment

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    Motivation: High-throughput methods for detecting molecular interactions have lead to a plethora of biological network data with much more yet to come, stimulating the development of techniques for biological network alignment. Analogous to sequence alignment, efficient and reliable network alignment methods will improve our understanding of biological systems. Network alignment is computationally hard. Hence, devising efficient network alignment heuristics is currently one of the foremost challenges in computational biology. 

Results: We present a superior heuristic network alignment algorithm, called Matching-based GRAph ALigner (M-GRAAL), which can process and integrate any number and type of similarity measures between network nodes (e.g., proteins), including, but not limited to, any topological network similarity measure, sequence similarity, functional similarity, and structural similarity. This is efficient in resolving ties in similarity measures and in finding a combination of similarity measures yielding the largest biologically sound alignments. When used to align protein-protein interaction (PPI) networks of various species, M-GRAAL exposes the largest known functional and contiguous regions of network similarity. Hence, we use M-GRAAL’s alignments to predict functions of un-annotated proteins in yeast, human, and bacteria _C. jejuni_ and _E. coli_. Furthermore, using M-GRAAL to compare PPI networks of different herpes viruses, we reconstruct their phylogenetic relationship and our phylogenetic tree is the same as sequenced-based one

    Semantically intelligent semi-automated ontology integration

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    An ontology is a way of information categorization and storage. Web Ontologies provide help in retrieving the required and precise information over the web. However, the problem of heterogeneity between ontologies may occur in the use of multiple ontologies of the same domain. The integration of ontologies provides a solution for the heterogeneity problem. Ontology integration is a solution to problem of interoperability in the knowledge based systems. Ontology integration provides a mechanism to find the semantic association between a pair of reference ontologies based on their concepts. Many researchers have been working on the problem of ontology integration; however, multiple issues related to ontology integration are still not addressed. This dissertation involves the investigation of the ontology integration problem and proposes a layer based enhanced framework as a solution to the problem. The comparison between concepts of reference ontologies is based on their semantics along with their syntax in the concept matching process of ontology integration. The semantic relationship of a concept with other concepts between ontologies and the provision of user confirmation (only for the problematic cases) are also taken into account in this process. The proposed framework is implemented and validated by providing a comparison of the proposed concept matching technique with the existing techniques. The test case scenarios are provided in order to compare and analyse the proposed framework in the analysis phase. The results of the experiments completed demonstrate the efficacy and success of the proposed framework
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