323 research outputs found
Diffeomorphic Metric Mapping and Probabilistic Atlas Generation of Hybrid Diffusion Imaging based on BFOR Signal Basis
We propose a large deformation diffeomorphic metric mapping algorithm to
align multiple b-value diffusion weighted imaging (mDWI) data, specifically
acquired via hybrid diffusion imaging (HYDI), denoted as LDDMM-HYDI. We then
propose a Bayesian model for estimating the white matter atlas from HYDIs. We
adopt the work given in Hosseinbor et al. (2012) and represent the q-space
diffusion signal with the Bessel Fourier orientation reconstruction (BFOR)
signal basis. The BFOR framework provides the representation of mDWI in the
q-space and thus reduces memory requirement. In addition, since the BFOR signal
basis is orthonormal, the L2 norm that quantifies the differences in the
q-space signals of any two mDWI datasets can be easily computed as the sum of
the squared differences in the BFOR expansion coefficients. In this work, we
show that the reorientation of the -space signal due to spatial
transformation can be easily defined on the BFOR signal basis. We incorporate
the BFOR signal basis into the LDDMM framework and derive the gradient descent
algorithm for LDDMM-HYDI with explicit orientation optimization. Additionally,
we extend the previous Bayesian atlas estimation framework for scalar-valued
images to HYDIs and derive the expectation-maximization algorithm for solving
the HYDI atlas estimation problem. Using real HYDI datasets, we show the
Bayesian model generates the white matter atlas with anatomical details.
Moreover, we show that it is important to consider the variation of mDWI
reorientation due to a small change in diffeomorphic transformation in the
LDDMM-HYDI optimization and to incorporate the full information of HYDI for
aligning mDWI
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Methods for improved mapping of brain lesion connectivity
Recent advances over the past two decades in neuroimaging methods have enabled us to map the connectivity of the brain. In parallel, pathophysiological models of brain disease have shifted from an emphasis on understanding pathology in specific brain regions to characterizing disruptions to interconnected neural networks. Nevertheless, these recent methods for mapping brain connectivity are still under development. Every step of the mapping process becomes a potential source for additional error due to noise or artifacts that could impact final analyses. Segmentation, parcellation, registration, and tractography are some of the steps where this occurs. Moreover, mapping the connectivity in a brain lesion is even more susceptible to errors in these steps. In this body of work, I describe multiple new methods for improving the accuracy of mapping lesion connectivity by reducing errors at the tractography stage which is the most error prone stage. First, we develop an approach for directly normalizing streamlines into a template space that avoids performing tractography in the normalized template space, reducing the error of connectomes constructed in the template space with respect to the ground truth native space connectome. Second, we develop a rapid approach for performing shortest path tractography and constructing shortest path probability weighted connectomes which increases the connection specificity relative to local streamline tracking approaches. We then demonstrate how our shortest path tractography approach can be used construct a disconnectome, a connectivity map of the proportion of connections lost due to intersecting a lesion. We then develop a fast, greedy graph-theoretic algorithm that extracts the maximally disconnected subgraph containing brain regions with the greatest shared loss of connectivity. Finally, we demonstrate how combining methods from diffusion based image inpainting and optimal estimation can be used to restore or inpaint corrupted fiber diffusion models in lesioned white matter tissue, enabling tractography and the study of lesion connectivity and modeling of microstructural measures in the patient’s native space
Large deformation diffeomorphic registration of diffusion-weighted imaging data
Registration plays an important role in group analysis of diffusion-weighted imaging (DWI) data. It can be used to build a reference anatomy for investigating structural variation or tracking changes in white matter. Unlike traditional scalar image registration where spatial alignment is the only focus, registration of DWI data requires both spatial alignment of structures and reorientation of local signal profiles. As such, DWI registration is much more complex and challenging than scalar image registration. Although a variety of algorithms has been proposed to tackle the problem, most of them are restricted by the zdiffusion model used for registration, making it difficult to fit to the registered data a different model. In this paper we describe a method that allows any diffusion model to be fitted after registration for subsequent multifaceted analysis. This is achieved by directly aligning DWI data using a large deformation diffeomorphic registration framework. Our algorithm seeks the optimal coordinate mapping by simultaneously considering structural alignment, local signal profile reorientation, and deformation regularization. Our algorithm also incorporates a multi-kernel strategy to concurrently register anatomical structures at different scales. We demonstrate the efficacy of our approach using in vivo data and report detailed qualitative and quantitative results in comparison with several different registration strategies
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