3,213 research outputs found
From Questions to Effective Answers: On the Utility of Knowledge-Driven Querying Systems for Life Sciences Data
We compare two distinct approaches for querying data in the context of the
life sciences. The first approach utilizes conventional databases to store the
data and intuitive form-based interfaces to facilitate easy querying of the
data. These interfaces could be seen as implementing a set of "pre-canned"
queries commonly used by the life science researchers that we study. The second
approach is based on semantic Web technologies and is knowledge (model) driven.
It utilizes a large OWL ontology and same datasets as before but associated as
RDF instances of the ontology concepts. An intuitive interface is provided that
allows the formulation of RDF triples-based queries. Both these approaches are
being used in parallel by a team of cell biologists in their daily research
activities, with the objective of gradually replacing the conventional approach
with the knowledge-driven one. This provides us with a valuable opportunity to
compare and qualitatively evaluate the two approaches. We describe several
benefits of the knowledge-driven approach in comparison to the traditional way
of accessing data, and highlight a few limitations as well. We believe that our
analysis not only explicitly highlights the specific benefits and limitations
of semantic Web technologies in our context but also contributes toward
effective ways of translating a question in a researcher's mind into precise
computational queries with the intent of obtaining effective answers from the
data. While researchers often assume the benefits of semantic Web technologies,
we explicitly illustrate these in practice
An introduction to Graph Data Management
A graph database is a database where the data structures for the schema
and/or instances are modeled as a (labeled)(directed) graph or generalizations
of it, and where querying is expressed by graph-oriented operations and type
constructors. In this article we present the basic notions of graph databases,
give an historical overview of its main development, and study the main current
systems that implement them
Semantic Web for data harmonization in Chinese medicine
Scientific studies to investigate Chinese medicine with Western medicine have been generating a large amount of data to be shared preferably under a global data standard. This article provides an overview of Semantic Web and identifies some representative Semantic Web applications in Chinese medicine. Semantic Web is proposed as a standard for representing Chinese medicine data and facilitating their integration with Western medicine data
Biomedical data integration in computational drug design and bioinformatics
[Abstract In recent years, in the post genomic era, more and more data is being generated by biological high throughput technologies, such as proteomics and transcriptomics. This omics data can be very useful, but the real challenge is to analyze all this data, as a whole, after integrating it. Biomedical data integration enables making queries to different, heterogeneous and distributed biomedical data sources. Data integration solutions can be very useful not only in the context of drug design, but also in biomedical information retrieval, clinical diagnosis, system biology, etc. In this review, we analyze the most common approaches to biomedical data integration, such as federated databases, data warehousing, multi-agent systems and semantic technology, as well as the solutions developed using these approaches in the past few years.Red Gallega de InvestigaciĂłn sobre Cáncer Colorrectal; Ref. 2009/58Programa Iberoamericano de Ciencia y TecnologĂa para el Desarrollo; 209RT-
0366Instituto de Salud Carlos III; PIO52048Instituto de Salud Carlos III; RD07/0067/0005Ministerio de Industria, Turismo y Comercio; TSI-020110-2009-
Linked Registries: Connecting Rare Diseases Patient Registries through a Semantic Web Layer
Patient registries are an essential tool to increase current knowledge
regarding rare diseases. Understanding these data is a vital step to improve
patient treatments and to create the most adequate tools for personalized
medicine. However, the growing number of disease-specific patient registries
brings also new technical challenges. Usually, these systems are developed as
closed data silos, with independent formats and models, lacking comprehensive
mechanisms to enable data sharing. To tackle these challenges, we developed a
Semantic Web based solution that allows connecting distributed and
heterogeneous registries, enabling the federation of knowledge between
multiple independent environments. This semantic layer creates a holistic view
over a set of anonymised registries, supporting semantic data representation,
integrated access, and querying. The implemented system gave us the
opportunity to answer challenging questions across disperse rare disease
patient registries. The interconnection between those registries using
Semantic Web technologies benefits our final solution in a way that we can
query single or multiple instances according to our needs. The outcome is a
unique semantic layer, connecting miscellaneous registries and delivering a
lightweight holistic perspective over the wealth of knowledge stemming from
linked rare disease patient registries
A Semantic Problem Solving Environment for Integrative Parasite Research: Identification of Intervention Targets for Trypanosoma cruzi
Effective research in parasite biology requires analyzing experimental lab data in the context of constantly expanding public data resources. Integrating lab data with public resources is particularly difficult for biologists who may not possess significant computational skills to acquire and process heterogeneous data stored at different locations. Therefore, we develop a semantic problem solving environment (SPSE) that allows parasitologists to query their lab data integrated with public resources using ontologies. An ontology specifies a common vocabulary and formal relationships among the terms that describe an organism, and experimental data and processes in this case. SPSE supports capturing and querying provenance information, which is metadata on the experimental processes and data recorded for reproducibility, and includes a visual query-processing tool to formulate complex queries without learning the query language syntax. We demonstrate the significance of SPSE in identifying gene knockout targets for T. cruzi. The overall goal of SPSE is to help researchers discover new or existing knowledge that is implicitly present in the data but not always easily detected. Results demonstrate improved usefulness of SPSE over existing lab systems and approaches, and support for complex query design that is otherwise difficult to achieve without the knowledge of query language syntax
Linked open drug data for pharmaceutical research and development
There is an abundance of information about drugs available on the Web. Data sources range from medicinal chemistry results, over the impact of drugs on gene expression, to the outcomes of drugs in clinical trials. These data are typically not connected together, which reduces the ease with which insights can be gained. Linking Open Drug Data (LODD) is a task force within the World Wide Web Consortium's (W3C) Health Care and Life Sciences Interest Group (HCLS IG). LODD has surveyed publicly available data about drugs, created Linked Data representations of the data sets, and identified interesting scientific and business questions that can be answered once the data sets are connected. The task force provides recommendations for the best practices of exposing data in a Linked Data representation. In this paper, we present past and ongoing work of LODD and discuss the growing importance of Linked Data as a foundation for pharmaceutical R&D data sharing
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Semantic Web repositories for genomics data using the eXframe platform
Background: With the advent of inexpensive assay technologies, there has been an unprecedented growth in genomics data as well as the number of databases in which it is stored. In these databases, sample annotation using ontologies and controlled vocabularies is becoming more common. However, the annotation is rarely available as Linked Data, in a machine-readable format, or for standardized queries using SPARQL. This makes large-scale reuse, or integration with other knowledge bases very difficult. Methods: To address this challenge, we have developed the second generation of our eXframe platform, a reusable framework for creating online repositories of genomics experiments. This second generation model now publishes Semantic Web data. To accomplish this, we created an experiment model that covers provenance, citations, external links, assays, biomaterials used in the experiment, and the data collected during the process. The elements of our model are mapped to classes and properties from various established biomedical ontologies. Resource Description Framework (RDF) data is automatically produced using these mappings and indexed in an RDF store with a built-in Sparql Protocol and RDF Query Language (SPARQL) endpoint. Conclusions: Using the open-source eXframe software, institutions and laboratories can create Semantic Web repositories of their experiments, integrate it with heterogeneous resources and make it interoperable with the vast Semantic Web of biomedical knowledge
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