299 research outputs found

    Construct, Merge, Solve and Adapt: Application to the repetition-free longest common subsequence problem

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    In this paper we present the application of a recently proposed, general, algorithm for combinatorial optimization to the repetition-free longest common subsequence problem. The applied algorithm, which is labelled Construct, Merge, Solve & Adapt, generates sub-instances based on merging the solution components found in randomly constructed solutions. These sub-instances are subsequently solved by means of an exact solver. Moreover, the considered sub-instances are dynamically changing due to adding new solution components at each iteration, and removing existing solution components on the basis of indicators about their usefulness. The results of applying this algorithm to the repetition-free longest common subsequence problem show that the algorithm generally outperforms competing approaches from the literature. Moreover, they show that the algorithm is competitive with CPLEX for small and medium size problem instances, whereas it outperforms CPLEX for larger problem instances.Peer ReviewedPostprint (author's final draft

    On the role of metaheuristic optimization in bioinformatics

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    Metaheuristic algorithms are employed to solve complex and large-scale optimization problems in many different fields, from transportation and smart cities to finance. This paper discusses how metaheuristic algorithms are being applied to solve different optimization problems in the area of bioinformatics. While the text provides references to many optimization problems in the area, it focuses on those that have attracted more interest from the optimization community. Among the problems analyzed, the paper discusses in more detail the molecular docking problem, the protein structure prediction, phylogenetic inference, and different string problems. In addition, references to other relevant optimization problems are also given, including those related to medical imaging or gene selection for classification. From the previous analysis, the paper generates insights on research opportunities for the Operations Research and Computer Science communities in the field of bioinformatics

    A comprehensive comparison of metaheuristics for the repetition-free longest common subsequence problem

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    This paper deals with an NP-hard string problem from the bio-informatics field: the repetition-free longest common subsequence problem. This problem has enjoyed an increasing interest in recent years, which has resulted in the application of several pure as well as hybrid metaheuristics. However, the literature lacks a comprehensive comparison between those approaches. Moreover, it has been shown that general purpose integer linear programming solvers are very efficient for solving many of the problem instances that were used so far in the literature. Therefore, in this work we extend the available benchmark set, adding larger instances to which integer linear programming solvers cannot be applied anymore. Moreover, we provide a comprehensive comparison of the approaches found in the literature. Based on the results we propose a hybrid between two of the best methods which turns out to inherit the complementary strengths of both methods.Peer ReviewedPostprint (author's final draft

    Exact algorithms for the repetition-bounded longest common subsequence problem

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    In this paper, we study exact, exponential-time algorithms for a variant of the classic Longest Common Subsequence problem called the Repetition-Bounded Longest Common Subsequence problem (or RBLCS, for short): Let an alphabet S be a finite set of symbols and an occurrence constraint Cocc be a function Cocc: S → N, assigning an upper bound on the number of occurrences of each symbol in S. Given two sequences X and Y over the alphabet S and an occurrence constraint Cocc, the goal of RBLCS is to find a longest common subsequence of X and Y such that each symbol s ∈ S appears at most Cocc(s) times in the obtained subsequence. The special case where Cocc(s) = 1 for every symbol s ∈ S is known as the Repetition-Free Longest Common Subsequence problem (RFLCS) and has been studied previously; e.g., in [1], Adi et al. presented a simple (exponential-time) exact algorithm for RFLCS. However, they did not analyze its time complexity in detail, and to the best of our knowledge, there are no previous results on the running times of any exact algorithms for this problem. Without loss of generality, we will assume that |X| ≤ |Y | and |X| = n. In this paper, we first propose a simpler algorithm for RFLCS based on the strategy used in [1] and show explicitly that its running time is O(1.44225n). Next, we provide a dynamic programming (DP) based algorithm for RBLCS and prove that its running time is O(1.44225n) for any occurrence constraint Cocc, and even less in certain special cases. In particular, for RFLCS, our DP-based algorithm runs in O(1.41422n) time, which is faster than the previous one. Furthermore, we prove NP-hardness and APX-hardness results for RBLCS on restricted instances

    Preventing premature convergence and proving the optimality in evolutionary algorithms

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    http://ea2013.inria.fr//proceedings.pdfInternational audienceEvolutionary Algorithms (EA) usually carry out an efficient exploration of the search-space, but get often trapped in local minima and do not prove the optimality of the solution. Interval-based techniques, on the other hand, yield a numerical proof of optimality of the solution. However, they may fail to converge within a reasonable time due to their inability to quickly compute a good approximation of the global minimum and their exponential complexity. The contribution of this paper is a hybrid algorithm called Charibde in which a particular EA, Differential Evolution, cooperates with a Branch and Bound algorithm endowed with interval propagation techniques. It prevents premature convergence toward local optima and outperforms both deterministic and stochastic existing approaches. We demonstrate its efficiency on a benchmark of highly multimodal problems, for which we provide previously unknown global minima and certification of optimality

    ALIGNMENT-FREE METHODS AND ITS APPLICATIONS

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    Comparing biological sequences remains one of the most vital activities in Bioinformatics. Comparing biological sequences would address the relatedness between species, and find similar structures that might lead to similar functions. Sequence alignment is the default method, and has been used in the domain for over four decades. It gained a lot of trust, but limitations and even failure has been reported, especially with the new generated genomes. These new generated genomes have bigger size, and to some extent suffer errors. Such errors come mainly as a result from the sequencing machine. These sequencing errors should be considered when submitting sequences to GenBank, for sequence comparison, it is often hard to address or even trace this problem. Alignment-based methods would fail with such errors, and even if biologists still trust them, reports showed failure with these methods. The poor results of alignment-based methods with erratic sequences, motivated researchers in the domain to look for alternatives. These alternative methods are alignment-free, and would overcome the shortcomings of alignment-based methods. The work of this thesis is based on alignment-free methods, and it conducts an in-depth study to evaluate these methods, and find the right domain’s application for them. The right domain for alignment-free methods could be by applying them to data that were subjected to manufactured errors, and test the methods provide better comparison results with data that has naturally severe errors. The two techniques used in this work are compression-based and motif-based (or k-mer based, or signal based). We also addressed the selection of the used motifs in the second technique, and how to progress the results by selecting specific motifs that would enhance the quality of results. In addition, we applied an alignment-free method to a different domain, which is gene prediction. We are using alignment-free in gene prediction to speed up the process of providing high quality results, and predict accurate stretches in the DNA sequence, which would be considered parts of genes

    Offline Learning for Sequence-based Selection Hyper-heuristics

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    This thesis is concerned with finding solutions to discrete NP-hard problems. Such problems occur in a wide range of real-world applications, such as bin packing, industrial flow shop problems, determining Boolean satisfiability, the traveling salesman and vehicle routing problems, course timetabling, personnel scheduling, and the optimisation of water distribution networks. They are typically represented as optimisation problems where the goal is to find a ``best'' solution from a given space of feasible solutions. As no known polynomial-time algorithmic solution exists for NP-hard problems, they are usually solved by applying heuristic methods. Selection hyper-heuristics are algorithms that organise and combine a number of individual low level heuristics into a higher level framework with the objective of improving optimisation performance. Many selection hyper-heuristics employ learning algorithms in order to enhance optimisation performance by improving the selection of single heuristics, and this learning may be classified as either online or offline. This thesis presents a novel statistical framework for the offline learning of subsequences of low level heuristics in order to improve the optimisation performance of sequenced-based selection hyper-heuristics. A selection hyper-heuristic is used to optimise the HyFlex set of discrete benchmark problems. The resulting sequences of low level heuristic selections and objective function values are used to generate an offline learning database of heuristic selections. The sequences in the database are broken down into subsequences and the mathematical concept of a logarithmic return is used to discriminate between ``effective'' subsequences, that tend to lead to improvements in optimisation performance, and ``disruptive'' subsequences that tend to lead to worsening performance. Effective subsequences are used to improve hyper-heuristics performance directly, by embedding them in a simple hyper-heuristic design, and indirectly as the inputs to an appropriate hyper-heuristic learning algorithm. Furthermore, by comparing effective subsequences across different problem domains it is possible to investigate the potential for cross-domain learning. The results presented here demonstrates that the use of well chosen subsequences of heuristics can lead to small, but statistically significant, improvements in optimisation performance

    Automatic Text Summarization Using Fuzzy Inference

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    Due to the high volume of information and electronic documents on the Web, it is almost impossible for a human to study, research and analyze this volume of text. Summarizing the main idea and the major concept of the context enables the humans to read the summary of a large volume of text quickly and decide whether to further dig into details. Most of the existing summarization approaches have applied probability and statistics based techniques. But these approaches cannot achieve high accuracy. We observe that attention to the concept and the meaning of the context could greatly improve summarization accuracy, and due to the uncertainty that exists in the summarization methods, we simulate human like methods by integrating fuzzy logic with traditional statistical approaches in this study. The results of this study indicate that our approach can deal with uncertainty and achieve better results when compared with existing methods

    CAD Tools for DNA Micro-Array Design, Manufacture and Application

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    Motivation: As the human genome project progresses and some microbial and eukaryotic genomes are recognized, numerous biotechnological processes have attracted increasing number of biologists, bioengineers and computer scientists recently. Biotechnological processes profoundly involve production and analysis of highthroughput experimental data. Numerous sequence libraries of DNA and protein structures of a large number of micro-organisms and a variety of other databases related to biology and chemistry are available. For example, microarray technology, a novel biotechnology, promises to monitor the whole genome at once, so that researchers can study the whole genome on the global level and have a better picture of the expressions among millions of genes simultaneously. Today, it is widely used in many fields- disease diagnosis, gene classification, gene regulatory network, and drug discovery. For example, designing organism specific microarray and analysis of experimental data require combining heterogeneous computational tools that usually differ in the data format; such as, GeneMark for ORF extraction, Promide for DNA probe selection, Chip for probe placement on microarray chip, BLAST to compare sequences, MEGA for phylogenetic analysis, and ClustalX for multiple alignments. Solution: Surprisingly enough, despite huge research efforts invested in DNA array applications, very few works are devoted to computer-aided optimization of DNA array design and manufacturing. Current design practices are dominated by ad-hoc heuristics incorporated in proprietary tools with unknown suboptimality. This will soon become a bottleneck for the new generation of high-density arrays, such as the ones currently being designed at Perlegen [109]. The goal of the already accomplished research was to develop highly scalable tools, with predictable runtime and quality, for cost-effective, computer-aided design and manufacturing of DNA probe arrays. We illustrate the utility of our approach by taking a concrete example of combining the design tools of microarray technology for Harpes B virus DNA data
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