M2U-net: Effective and efficient retinal vessel segmentation for real-world applications

In this paper, we present a novel neural network architecture for retinal vessel segmentation that improves over the state of the art on two benchmark datasets, is the first to run in real time on high resolution images, and its small memory and processing requirements make it deployable in mobile and embedded systems. The M2U-Net has a new encoder-decoder architecture that is inspired by the U-Net. It adds pretrained components of MobileNetV2 in the encoder part and novel contractive bottleneck blocks in the decoder part that, combined with bilinear upsampling, drastically reduce the parameter count to 0.55M compared to 31.03M in the original U-Net. We have evaluated its performance against a wide body of previously published results on three public datasets. On two of them, the M2U-Net achieves new state-of-the-art performance by a considerable margin. When implemented on a GPU, our method is the first to achieve real-time inference speeds on high-resolution fundus images. We also implemented our proposed network on an ARM-based embedded system where it segments images in between 0.6 and 15 sec, depending on the resolution. Thus, the M2U-Net enables a number of applications of retinal vessel structure extraction, such as early diagnosis of eye diseases, retinal biometric authentication systems, and robot assisted microsurgery

Performance analysis of massively parallel embedded hardware architectures for retinal image processing

This paper examines the implementation of a retinal vessel tree extraction technique on different hardware platforms and architectures. Retinal vessel tree extraction is a representative application of those found in the domain of medical image processing. The low signal-to-noise ratio of the images leads to a large amount of low-level tasks in order to meet the accuracy requirements. In some applications, this might compromise computing speed. This paper is focused on the assessment of the performance of a retinal vessel tree extraction method on different hardware platforms. In particular, the retinal vessel tree extraction method is mapped onto a massively parallel SIMD (MP-SIMD) chip, a massively parallel processor array (MPPA) and onto an field-programmable gate arrays (FPGA)This work is funded by Xunta de Galicia under the projects 10PXIB206168PR and 10PXIB206037PR and the program Maria BarbeitoS

Retinal blood vessel segmentation for macula detachment surgery monitoring instruments

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/144261/1/cta2462_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/144261/2/cta2462.pd

Retinal blood vessel segmentation: methods and implementations

Since the retinal blood vessel has been acknowledged as an indispensable element in both ophthalmological and cardiovascular disease diagnosis, the accurate segmentation of the retinal vessel tree has become the prerequisite step for automatic or computer-aided diagnosis systems. This thesis, therefore, has investigated different works of image segmentation algorithms and techniques, including unsupervised and supervised methods. Further, the thesis has developed and implemented two systems of the accurate retinal vessel segmentation. The methodologies explained and analyzed in this thesis, have been selected as the most efficient approaches to achieve higher precision, better robustness, and faster execution speed, to meet the strict standard of the modern medical imaging. Based on the intensive investigation and experiments, this thesis has proposed two outstanding implementations of the retinal blood vessel segmentation. The first implementation focuses on the fast, accurate and robust extraction of the retinal vessels using unsupervised techniques, by applying morphology-based global thresholding to draw the retinal venule structure and centerline detection to extract the capillaries. Besides, this system has been designed to minimize the computing complexity and to process multiple independent procedures in parallel. The second proposed system has especially focused on robustness and accuracy in regardless of execution time. This method has utilized the full convolutional neural network trained from a pre-trained semantic segmentation model, which is also called the transfer deep learning. This proposed method has simplified the typical retinal vessel segmentation problem from full-size image segmentation to regional vessel element recognition. Both of the implementations have outperformed their related works and have presented a remarkable scientific value for future computer-aided diagnosis applications. What’s more, this thesis is also a research guide which provide readers with the comprehensive knowledge on how to research on the task of retinal vessel segmentation

Retinal blood vessel segmentation: methods and implementations

Since the retinal blood vessel has been acknowledged as an indispensable element in both ophthalmological and cardiovascular disease diagnosis, the accurate segmentation of the retinal vessel tree has become the prerequisite step for automatic or computer-aided diagnosis systems. This thesis, therefore, has investigated different works of image segmentation algorithms and techniques, including unsupervised and supervised methods. Further, the thesis has developed and implemented two systems of the accurate retinal vessel segmentation. The methodologies explained and analyzed in this thesis, have been selected as the most efficient approaches to achieve higher precision, better robustness, and faster execution speed, to meet the strict standard of the modern medical imaging. Based on the intensive investigation and experiments, this thesis has proposed two outstanding implementations of the retinal blood vessel segmentation. The first implementation focuses on the fast, accurate and robust extraction of the retinal vessels using unsupervised techniques, by applying morphology-based global thresholding to draw the retinal venule structure and centerline detection to extract the capillaries. Besides, this system has been designed to minimize the computing complexity and to process multiple independent procedures in parallel. The second proposed system has especially focused on robustness and accuracy in regardless of execution time. This method has utilized the full convolutional neural network trained from a pre-trained semantic segmentation model, which is also called the transfer deep learning. This proposed method has simplified the typical retinal vessel segmentation problem from full-size image segmentation to regional vessel element recognition. Both of the implementations have outperformed their related works and have presented a remarkable scientific value for future computer-aided diagnosis applications. What’s more, this thesis is also a research guide which provide readers with the comprehensive knowledge on how to research on the task of retinal vessel segmentation

Retinal blood vessel segmentation: methods and implementations

Since the retinal blood vessel has been acknowledged as an indispensable element in both ophthalmological and cardiovascular disease diagnosis, the accurate segmentation of the retinal vessel tree has become the prerequisite step for automatic or computer-aided diagnosis systems. This thesis, therefore, has investigated different works of image segmentation algorithms and techniques, including unsupervised and supervised methods. Further, the thesis has developed and implemented two systems of the accurate retinal vessel segmentation. The methodologies explained and analyzed in this thesis, have been selected as the most efficient approaches to achieve higher precision, better robustness, and faster execution speed, to meet the strict standard of the modern medical imaging. Based on the intensive investigation and experiments, this thesis has proposed two outstanding implementations of the retinal blood vessel segmentation. The first implementation focuses on the fast, accurate and robust extraction of the retinal vessels using unsupervised techniques, by applying morphology-based global thresholding to draw the retinal venule structure and centerline detection to extract the capillaries. Besides, this system has been designed to minimize the computing complexity and to process multiple independent procedures in parallel. The second proposed system has especially focused on robustness and accuracy in regardless of execution time. This method has utilized the full convolutional neural network trained from a pre-trained semantic segmentation model, which is also called the transfer deep learning. This proposed method has simplified the typical retinal vessel segmentation problem from full-size image segmentation to regional vessel element recognition. Both of the implementations have outperformed their related works and have presented a remarkable scientific value for future computer-aided diagnosis applications. What’s more, this thesis is also a research guide which provide readers with the comprehensive knowledge on how to research on the task of retinal vessel segmentation

Flexible Hardware Architectures for Retinal Image Analysis

RÉSUMÉ Des millions de personnes autour du monde sont touchées par le diabète. Plusieurs complications oculaires telle que la rétinopathie diabétique sont causées par le diabète, ce qui peut conduire à une perte de vision irréversible ou même la cécité si elles ne sont pas traitées. Des examens oculaires complets et réguliers par les ophtalmologues sont nécessaires pour une détection précoce des maladies et pour permettre leur traitement. Comme solution préventive, un protocole de dépistage impliquant l'utilisation d'images numériques du fond de l'œil a été adopté. Cela permet aux ophtalmologistes de surveiller les changements sur la rétine pour détecter toute présence d'une maladie oculaire. Cette solution a permis d'obtenir des examens réguliers, même pour les populations des régions éloignées et défavorisées. Avec la grande quantité d'images rétiniennes obtenues, des techniques automatisées pour les traiter sont devenues indispensables. Les techniques automatisées de détection des maladies des yeux ont été largement abordées par la communauté scientifique. Les techniques développées ont atteint un haut niveau de maturité, ce qui a permis entre autre le déploiement de solutions en télémédecine. Dans cette thèse, nous abordons le problème du traitement de volumes élevés d'images rétiniennes dans un temps raisonnable dans un contexte de dépistage en télémédecine. Ceci est requis pour permettre l'utilisation pratique des techniques développées dans le contexte clinique. Dans cette thèse, nous nous concentrons sur deux étapes du pipeline de traitement des images rétiniennes. La première étape est l'évaluation de la qualité de l'image rétinienne. La deuxième étape est la segmentation des vaisseaux sanguins rétiniens. L’évaluation de la qualité des images rétinienne après acquisition est une tâche primordiale au bon fonctionnement de tout système de traitement automatique des images de la rétine. Le rôle de cette étape est de classifier les images acquises selon leurs qualités, et demander une nouvelle acquisition en cas d’image de mauvaise qualité. Plusieurs algorithmes pour évaluer la qualité des images rétiniennes ont été proposés dans la littérature. Cependant, même si l'accélération de cette tâche est requise en particulier pour permettre la création de systèmes mobiles de capture d'images rétiniennes, ce sujet n'a pas encore été abordé dans la littérature. Dans cette thèse, nous ciblons un algorithme qui calcule les caractéristiques des images pour permettre leur classification en mauvaise, moyenne ou bonne qualité. Nous avons identifié le calcul des caractéristiques de l'image comme une tâche répétitive qui nécessite une accélération. Nous nous sommes intéressés plus particulièrement à l’accélération de l’algorithme d’encodage à longueur de séquence (Run-Length Matrix – RLM). Nous avons proposé une première implémentation complètement logicielle mise en œuvre sous forme d’un système embarqué basé sur la technologie Zynq de Xilinx. Pour accélérer le calcul des caractéristiques, nous avons conçu un co-processeur capable de calculer les caractéristiques en parallèle implémenté sur la logique programmable du FPGA Zynq. Nous avons obtenu une accélération de 30,1 × pour la tâche de calcul des caractéristiques de l’algorithme RLM par rapport à son implémentation logicielle sur la plateforme Zynq. La segmentation des vaisseaux sanguins rétiniens est une tâche clé dans le pipeline du traitement des images de la rétine. Les vaisseaux sanguins et leurs caractéristiques sont de bons indicateurs de la santé de la rétine. En outre, leur segmentation peut également aider à segmenter les lésions rouges, indicatrices de la rétinopathie diabétique. Plusieurs techniques de segmentation des vaisseaux sanguins rétiniens ont été proposées dans la littérature. Des architectures matérielles ont également été proposées pour accélérer certaines de ces techniques. Les architectures existantes manquent de performances et de flexibilité de programmation, notamment pour les images de haute résolution. Dans cette thèse, nous nous sommes intéressés à deux techniques de segmentation du réseau vasculaire rétinien, la technique du filtrage adapté et la technique des opérateurs de ligne. La technique de filtrage adapté a été ciblée principalement en raison de sa popularité. Pour cette technique, nous avons proposé deux architectures différentes, une architecture matérielle personnalisée mise en œuvre sur FPGA et une architecture basée sur un ASIP. L'architecture matérielle personnalisée a été optimisée en termes de surface et de débit de traitement pour obtenir des performances supérieures par rapport aux implémentations existantes dans la littérature. Cette implémentation est plus efficace que toutes les implémentations existantes en termes de débit. Pour l'architecture basée sur un processeur à jeu d’instructions spécialisé (Application-Specific Instruction-set Processor – ASIP), nous avons identifié deux goulets d'étranglement liés à l'accès aux données et à la complexité des calculs de l'algorithme. Nous avons conçu des instructions spécifiques ajoutées au chemin de données du processeur. L'ASIP a été rendu 7.7 × plus rapide par rapport à son architecture de base. La deuxième technique pour la segmentation des vaisseaux sanguins est l'algorithme détecteur de ligne multi-échelle (Multi-Scale Ligne Detector – MSLD). L'algorithme MSLD est choisi en raison de ses performances et de son potentiel à détecter les petits vaisseaux sanguins. Cependant, l'algorithme fonctionne en multi-échelle, ce qui rend l’algorithme gourmand en mémoire. Pour résoudre ce problème et permettre l'accélération de son exécution, nous avons proposé un algorithme efficace en terme de mémoire, conçu et implémenté sur FPGA. L'architecture proposée a réduit de façon drastique les exigences de l’algorithme en terme de mémoire en réutilisant les calculs et la co-conception logicielle/matérielle. Les deux architectures matérielles proposées pour la segmentation du réseau vasculaire rétinien ont été rendues flexibles pour pouvoir traiter des images de basse et de haute résolution. Ceci a été réalisé par le développement d'un compilateur spécifique capable de générer une description HDL de bas niveau de l'algorithme à partir d'un ensemble de paramètres. Le compilateur nous a permis d’optimiser les performances et le temps de développement. Dans cette thèse, nous avons introduit deux architectures qui sont, au meilleur de nos connaissances, les seules capables de traiter des images à la fois de basse et de haute résolution.----------ABSTRACT Millions of people all around the world are affected by diabetes. Several ocular complications such as diabetic retinopathy are caused by diabetes, which can lead to irreversible vision loss or even blindness if not treated. Regular comprehensive eye exams by eye doctors are required to detect the diseases at earlier stages and permit their treatment. As a preventing solution, a screening protocol involving the use of digital fundus images was adopted. This allows eye doctors to monitor changes in the retina to detect any presence of eye disease. This solution made regular examinations widely available, even to populations in remote and underserved areas. With the resulting large amount of retinal images, automated techniques to process them are required. Automated eye detection techniques are largely addressed by the research community, and now they reached a high level of maturity, which allows the deployment of telemedicine solutions. In this thesis, we are addressing the problem of processing a high volume of retinal images in a reasonable time. This is mandatory to allow the practical use of the developed techniques in a clinical context. In this thesis, we focus on two steps of the retinal image pipeline. The first step is the retinal image quality assessment. The second step is the retinal blood vessel segmentation. The evaluation of the quality of the retinal images after acquisition is a primary task for the proper functioning of any automated retinal image processing system. The role of this step is to classify the acquired images according to their quality, which will allow an automated system to request a new acquisition in case of poor quality image. Several algorithms to evaluate the quality of retinal images were proposed in the literature. However, even if the acceleration of this task is required, especially to allow the creation of mobile systems for capturing retinal images, this task has not yet been addressed in the literature. In this thesis, we target an algorithm that computes image features to allow their classification to bad, medium or good quality. We identified the computation of image features as a repetitive task that necessitates acceleration. We were particularly interested in accelerating the Run-Length Matrix (RLM) algorithm. We proposed a first fully software implementation in the form of an embedded system based on Xilinx's Zynq technology. To accelerate the features computation, we designed a co-processor able to compute the features in parallel, implemented on the programmable logic of the Zynq FPGA. We achieved an acceleration of 30.1× over its software implementation for the features computation part of the RLM algorithm. Retinal blood vessel segmentation is a key task in the pipeline of retinal image processing. Blood vessels and their characteristics are good indicators of retina health. In addition, their segmentation can also help to segment the red lesions, indicators of diabetic retinopathy. Several techniques have been proposed in the literature to segment retinal blood vessels. Hardware architectures have also been proposed to accelerate blood vessel segmentation. The existing architectures lack in terms of performance and programming flexibility, especially for high resolution images. In this thesis, we targeted two techniques, matched filtering and line operators. The matched filtering technique was targeted mainly because of its popularity. For this technique, we proposed two different architectures, a custom hardware architecture implemented on FPGA, and an Application Specific Instruction-set Processor (ASIP) based architecture. The custom hardware architecture area and timing were optimized to achieve higher performances in comparison to existing implementations. Our custom hardware implementation outperforms all existing implementations in terms of throughput. For the ASIP based architecture, we identified two bottlenecks related to data access and computation intensity of the algorithm. We designed two specific instructions added to the processor datapath. The ASIP was made 7.7× more efficient in terms of execution time compared to its basic architecture. The second technique for blood vessel segmentation is the Multi-Scale Line Detector (MSLD) algorithm. The MSLD algorithm is selected because of its performance and its potential to detect small blood vessels. However, the algorithm works at multiple scales which makes it memory intensive. To solve this problem and allow the acceleration of its execution, we proposed a memory-efficient algorithm designed and implemented on FPGA. The proposed architecture reduces drastically the memory requirements of the algorithm by reusing the computations and SW/HW co-design. The two hardware architectures proposed for retinal blood vessel segmentation were made flexible to be able to process low and high resolution images. This was achieved by the development of a specific compiler able to generate low-level HDL descriptions of the algorithm from a set of the algorithm parameters. The compiler enabled us to optimize performance and development time. In this thesis, we introduce two novel architectures which are, to the best of our knowledge, the only ones able to process both low and high resolution images