Multi-site capacity planning and business optimisation for process industries.

Changing market conditions, volatile customer demand, intense competition and tightness of capital are some of the primary characteristics of the global economy that affect process industries nowadays. The main objective of the thesis is to facilitate business decision-making in today's increasingly complex and highly uncertain market environment by applying mathematical programming techniques for multi-site capacity planning and business optimisation in process industries. In the first part of the thesis, the problem of multi-site capacity planning under uncertainty in the pharmaceutical industry is addressed. A comprehensive two-stage, multi-scenario mixed-integer linear programming (MILP) model is proposed able to determine an optimal product portfolio and multi-site investment plan in the face of clinical trials uncertainty. A hierarchical algorithm is also developed in order to reduce the computational effort needed for the solution of the resulting large-scale MILP model. The applicability of the proposed solution methodology is demonstrated by a number of illustrative examples. The second part addresses the problem of business optimisation for customer demand management in process industries. A customer demand forecasting approach is developed based on support vector regression analysis. The proposed three-step algorithm is able to extract the underlying customer demand patterns from historical sales data and derive an accurate forecast as demonstrated through a number of illustrative examples. An active demand management approach for close substitute products is also developed based on price optimisation. The proposed methodology is able to determine optimal pricing policies as well as output levels, while taking into consideration manufacturing costs, resource availability, customer demand elasticity, outsourcing and market competition. An iterative algorithm is developed able to determine Nash equilibrium in prices for competing companies as demonstrated by the illustrative examples

Global supply chains of high value low volume products

Imperial Users onl

Methods and algorithms for integrated multi-scale optimisation of production planning and scheduling

Imperial Users onl

Production planning of biopharmaceutical manufacture.

Multiproduct manufacturing facilities running on a campaign basis are increasingly becoming the norm for biopharmaceuticals, owing to high risks of clinical failure, regulatory pressures and the increasing number of therapeutics in clinical evaluation. The need for such flexible plants and cost-effective manufacture pose significant challenges for planning and scheduling, which are compounded by long production lead times, intermediate product stability issues and the high cost - low volume nature of biopharmaceutical manufacture. Scheduling and planning decisions are often made in the presence of variable product titres, campaign durations, contamination rates and product demands. Hence this thesis applies mathematical programming techniques to the planning of biopharmaceutical manufacture in order to identify more optimal production plans under different manufacturing scenarios. A deterministic mixed integer linear programming (MILP) medium term planning model which explicitly accounts for upstream and downstream processing is presented. A multiscenario MILP model for the medium term planning of biopharmaceutical manufacture under uncertainty is presented and solved using an iterative solution procedure. An alternative stochastic formulation for the medium term planning of biomanufacture under uncertainty based on the principles of chance constrained programming is also presented. To help manage the risks of long term capacity planning in the biopharmaceutical industry, a goal programming extension is presented which accounts for multiple objectives including cost, risk and customer service level satisfaction. The model is applied to long term capacity analysis of a mix of contractors and owned biopharmaceutical manufacturing facilities. In the final sections of this thesis an example of a commercial application of this work is presented, followed by a discussion on related validation issues in the biopharmaceutical industry. The work in this thesis highlighted the benefits of applying mathematical programming techniques for production planning of biopharmaceutical manufacturing facilities, so as to enhance the biopharmaceutical industry's strategic and operational decision-making towards achieving more cost-effective manufacture

A contribution to support decision making in energy/water sypply chain optimisation

The seeking of process sustainability forces enterprises to change their operations. Additionally, the industrial globalization implies a very dynamic market that, among other issues, promotes the enterprises competition. Therefore, the efficient control and use of their Key Performance Indicators, including profitability, cost reduction, demand satisfaction and environmental impact associated to the development of new products, is a significant challenge. All the above indicators can be efficiently controlled through the Supply Chain Management. Thus, companies work towards the optimization of their individual operations under competitive environments taking advantage of the flexibility provided by the virtually inexistent world market restrictions. This is achieved by the coordination of the resource flows, across all the entities and echelons belonging to the system network. Nevertheless, such coordination is significantly complicated if considering the presence of uncertainty and even more if seeking for a win-win outcome. The purpose of this thesis is extending the current decision making strategies to expedite these tasks in industrial processes. Such a contribution is based on the development of efficient mathematical models that allows coordinating large amount of information synchronizing the production and distribution tasks in terms of economic, environmental and social criteria. This thesis starts presents an overview of the requirements of sustainable production processes, describing and analyzing the current methods and tools used and identifying the most relevant open issues. All the above is always within the framework of Process System Engineering literature. The second part of this thesis is focused in stressing the current Multi-Objective solution strategies. During this part, first explores how the profitability of the Supply Chain can be enhanced by considering simultaneously multiple objectives under demand uncertainties. Particularly, solution frameworks have been proposed in which different multi-criteria decision making strategies have been combined with stochastic approaches. Furthermore, additional performance indicators (including financial and operational ones) have been included in the same solution framework to evaluate its capabilities. This framework was also applied to decentralized supply chains problems in order to explore its capabilities to produce solution that improves the performances of each one of the SC entities simultaneously. Consequently, a new generalized mathematical formulation which integrates many performance indicators in the production process within a supply chain is efficiently solved. Afterwards, the third part of the thesis extends the proposed solution framework to address the uncertainty management. Particularly, the consideration of different types and sources of uncertainty (e.g. external and internal ones) where considered, through the implementation of preventive approaches. This part also explores the use of solution strategies that efficiently selects the number of scenarios that represent the uncertainty conditions. Finally, the importance and effect of each uncertainty source over the process performance is detailed analyzed through the use of surrogate models that promote the sensitivity analysis of those uncertainties. The third part of this thesis is focused on the integration of the above multi-objective and uncertainty approaches for the optimization of a sustainable Supply Chain. Besides the integration of different solution approaches, this part also considers the integration of hierarchical decision levels, by the exploitation of mathematical models that assess the consequences of considering simultaneously design and planning decisions under centralized and decentralized Supply Chains. Finally, the last part of this thesis provides the final conclusions and further work to be developed.La globalización industrial genera un ambiente dinámico en los mercados que, entre otras cosas, promueve la competencia entre corporaciones. Por lo tanto, el uso eficiente de las los indicadores de rendimiento, incluyendo rentabilidad, satisfacción de la demanda y en general el impacto ambiental, representa un area de oportunidad importante. El control de estos indicadores tiene un efecto positivo si se combinan con la gestión de cadena de suministro. Por lo tanto, las compañías buscan definir sus operaciones para permanecer activas dentro de un ambiente competitivo, tomando en cuenta las restricciones en el mercado mundial. Lo anterior puede ser logrado mediante la coordinación de los flujos de recursos a través de todas las entidades y escalones pertenecientes a la red del sistema. Sin embargo, dicha coordinación se complica significativamente si se quiere considerar la presencia de incertidumbre, y aún más, si se busca exclusivamente un ganar-ganar. El propósito de esta tesis es extender el alcance de las estrategias de toma de decisiones con el fin de facilitar estas tareas dentro de procesos industriales. Estas contribuciones se basan en el desarrollo de modelos matemáticos eficientes que permitan coordinar grandes cantidades de información sincronizando las tareas de producción y distribución en términos económicos, ambientales y sociales. Esta tesis inicia presentando una visión global de los requerimientos de un proceso de producción sostenible, describiendo y analizando los métodos y herramientas actuales así como identificando las áreas de oportunidad más relevantes dentro del marco de ingeniería de procesos La segunda parte se enfoca en enfatizar las capacidades de las estrategias de solución multi-objetivo, durante la cual, se explora el mejoramiento de la rentabilidad de la cadena de suministro considerando múltiples objetivos bajo incertidumbres en la demanda. Particularmente, diferentes marcos de solución han sido propuestos en los que varias estrategias de toma de decisión multi-criterio han sido combinadas con aproximaciones estocásticas. Por otra parte, indicadores de rendimiento (incluyendo financiero y operacional) han sido incluidos en el mismo marco de solución para evaluar sus capacidades. Este marco fue aplicado también a problemas de cadenas de suministro descentralizados con el fin de explorar sus capacidades de producir soluciones que mejoran simultáneamente el rendimiento para cada uno de las entidades dentro de la cadena de suministro. Consecuentemente, una nueva formulación que integra varios indicadores de rendimiento en los procesos de producción fue propuesta y validada. La tercera parte de la tesis extiende el marco de solución propuesto para abordar el manejo de incertidumbres. Particularmente, la consideración de diferentes tipos y fuentes de incertidumbre (p.ej. externos e internos) fueron considerados, mediante la implementación de aproximaciones preventivas. Esta parte también explora el uso de estrategias de solución que elige eficientemente el número de escenarios necesario que representan las condiciones inciertas. Finalmente, la importancia y efecto de cada una de las fuentes de incertidumbre sobre el rendimiento del proceso es analizado en detalle mediante el uso de meta modelos que promueven el análisis de sensibilidad de dichas incertidumbres. La tercera parte de esta tesis se enfoca en la integración de las metodologías de multi-objetivo e incertidumbre anteriormente expuestas para la optimización de cadenas de suministro sostenibles. Además de la integración de diferentes métodos. Esta parte también considera la integración de diferentes niveles jerárquicos de decisión, mediante el aprovechamiento de modelos matemáticos que evalúan lasconsecuencias de considerar simultáneamente las decisiones de diseño y planeación de una cadena de suministro centralizada y descentralizada. La parte final de la tesis detalla las conclusiones y el trabajo a futuro necesario sobre esta línea de investigaciónPostprint (published version

A review of discrete-time optimization models for tactical production planning

This is an Accepted Manuscript of an article published in International Journal of Production Research on 27 Mar 2014, available online: http://doi.org/10.1080/00207543.2014.899721[EN] This study presents a review of optimization models for tactical production planning. The objective of this research is to identify streams and future research directions in this field based on the different classification criteria proposed. The major findings indicate that: (1) the most popular production-planning area is master production scheduling with a big-bucket time-type period; (2) most of the considered limited resources correspond to productive resources and, to a lesser extent, to inventory capacities; (3) the consideration of backlogs, set-up times, parallel machines, overtime capacities and network-type multisite configuration stand out in terms of extensions; (4) the most widely used modelling approach is linear/integer/mixed integer linear programming solved with exact algorithms, such as branch-and-bound, in commercial MIP solvers; (5) CPLEX, C and its variants and Lindo/Lingo are the most popular development tools among solvers, programming languages and modelling languages, respectively; (6) most works perform numerical experiments with random created instances, while a small number of works were validated by real-world data from industrial firms, of which the most popular are sawmills, wood and furniture, automobile and semiconductors and electronic devices.This study has been funded by the Universitat Politècnica de València projects: ‘Material Requirement Planning Fourth Generation (MRPIV)’ (Ref. PAID-05-12) and ‘Quantitative Models for the Design of Socially Responsible Supply Chains under Uncertainty Conditions. Application of Solution Strategies based on Hybrid Metaheuristics’ (PAID-06-12).Díaz-Madroñero Boluda, FM.; Mula, J.; Peidro Payá, D. (2014). A review of discrete-time optimization models for tactical production planning. International Journal of Production Research. 52(17):5171-5205. doi:10.1080/00207543.2014.899721S51715205521

Planning of outsourced operations in pharmaceutical supply chains

In this dissertation, we focus on the planning and control of supply chains where part of the supply chain is outsourced to a contract manufacturer(s). Supply Chain Management deals with the integration of business processes from end-customers through original suppliers that provide products, services and information that add value for customers (Cooper et al., 1997). In a narrow sense, a supply chain can be ‘owned’ by one large company with several sites, often located in different countries. Planning and coordinating the materials and information flows within such a worldwide operating company can be a challenging task. However, the decision making is easier than in case more companies are involved in a supply chain, since the sites are part of one organization with one board and it is likely that the decision makers have full access to information needed for the supply chain planning. Outsourcing is an ‘act of moving some of a firm’s internal activities and decision responsibilities to outside providers’ (Chase et al., 2004) and it has been studied extensively in the literature.Outsourcing is developing in many industries, but in this dissertation, we focus on outsourcing in the pharmaceutical industry, where outsourced supply chain structures are rapidly developing. Recent studies show that the global pharmaceutical outsourcing market has doubled from 2001 to 2007 and it is expected to further increase in the upcoming years. In the pharmaceutical industry, the outsourcing relationship is typically long-term and customers often require high service levels. Due to high setup costs, production is conducted in fixed large batch sizes and campaign sizes. The cumulative lead time within the supply chain is more than one year, whereas the customer lead time is about two months. In this industry, production activities are outsourced for three main reasons. First, intellectual property legislation requires outsourcing the production activities to a contract manufacturer that owns the patent for specific technologies that are needed to perform the production activities. Second, expensive technologies or tight (internal) capacity restrictions also result in outsourcing. Third, to limit the supply uncertainty, companies outsource to have an external source producing the same product next to an internal source. This dissertation deals with the planning and control of outsourced supply chains, which are supply chains where part of the supply chain is outsourced to a contract manufacturer. Most supply chain operations planning models from the literature assume that the supply chain is planned at some level of aggregation and that further coordination is conducted at a more detailed level by lower planning levels. These concepts implicitly assume that the lower planning level and the operations are conducted within the same company with full information availability and full control over the operations, which is not case when part of the supply chain is outsourced. Hence, the objective of this dissertation is to obtain insights into the implications of outsourcing on the supply chain planning models. First, we review the literature on outsourcing research and we find that little is known on the operational planning decisions in an outsourced supply chain and on the implications of outsourcing on the operations planning. The literature on outsourcing at the operational level uses outsourcing purely as a secondary source to control performances such as the delivery reliability. Consequently, we discuss two case studies that we conducted into outsourced supply chains to understand the implications of outsourcing on the supply chain operations planning function, where the contract manufacturer is the only source of supply. The main implications of the planning and control of outsourced supply chains can be summarized in three categories: limited information transparency, limited control over the detailed planning and priorities at the contract manufacturer, and contractual obligations. Below, we discuss these in more detail. In order to decide on the release of materials and resources in a supply chain, it is required that the decision maker is able to frequently monitor the status of the supply chain. In an outsourced supply chain, the outsourcer does not have access to all relevant information of the entire supply chain, especially not to the available capacity in each period, also because the contract manufacturer serves a number of different (and sometimes even competing) outsourcers on the same production line. Moreover, the contract manufacturer plans and controls its part of the supply chain based on rules and priorities that are unknown to the outsourcer. This results in facing an uncertain capacity allocation by the outsourcer. Another implication is that the contract manufacturer requires by contract to reserve capacity slots prior to ordering. These reservations are subject to an acceptation decision, which means that part of the reservation quantity can be rejected. The accepted reservation quantity bounds the order quantity that follows later on. Therefore, another main insight from the case study is that in an outsourcing relationship, the order process consists of different (hierarchically connected) decisions in time. In the ordering process, the uncertain capacity allocation of the contract manufacturer should be incorporated. Hence, the order release mechanism requires a richer and more developed communication and ordering pattern than commonly assumed in practice. In a subsequent study, we build on this insight and we design three different order release mechanisms to investigate to what extent a more complicated order release function improves (or deteriorates) the performance of the supply chain operations planning models. The order release mechanisms differ in the number of decision levels and they incorporate the probabilistic behaviour of the contract manufacturer. Based on a simulation study, we show that a more advanced order release strategy that captures the characteristics of outsourcing performs significantly better than a simple order release strategy that is commonly used in practice. We also discuss the conditions for a successful implementation of the more advanced order release strategy. In another study, we study the case where the contract manufacturer is a second source next to an internal manufacturing source for the same product and where the outsourcer faces inaccurate demand forecasts. The two sources are constraining the supply quantities in different ways. Its own manufacturing source is more rigid, cheaper and tightly capacitated, whereas the contract manufacturer is more flexible but more expensive. In that study, we compare the performance of two different allocation strategies by a simulation study in which we solve the model in a rolling horizon setting. The results show that the rigid allocation strategy (the cheaper source supplies each period a constant quantity) performs substantially better than the dynamic allocation strategy (each period the allocation quantities are dynamic) if the parameters are chosen properly. In another study, we study the outsourcer’s problem of deciding on the optimal reservation quantity under capacity uncertainty, i.e., without knowing what part of the reservation will be accepted. In that study, we develop a stochastic dynamic programming model for the problem and we characterize the optimal reservation and order policies. We conduct a numerical study where we also consider the case where the capacity allocation is dependent on the demand distribution. For that case, we show the structure of the optimal policies based on the numerical study. Further, the numerical results reveal several interesting managerial insights, such as that the optimal reservation policy is little sensitive to the uncertainty of the capacity allocation from the contract manufacturer. In that case, the optimal reservation quantities hardly increase, but the optimal policy suggests increasing the utilization of the allocated capacity. We also study the outsourced supply chain from the contract manufacturer’s perspective. In that study, we consider the case where the contract manufacturer serves a number of outsourcers with different levels of uncertainty. The contract manufacturer faces the question of how to allocate the contractual capacity flexibility in an optimal way. More precisely, we focus on the contract manufacturer’s decision to make the acceptation decision under uncertainty. The more the contract manufacturer accepts from an outsourcer, the more risk is taken by the contract manufacturer, as the outsourcer might not fully utilize the accepted reservation quantity. However, we assume that the outsourcer is willing to pay an additional amount to compensate the contract manufacturer for that risk. We develop a mixed-integer programming model, which optimizes the allocation of capacity flexibility by maximizing the expected profit. Offering more flexibility to the more risky outsourcer generates higher revenue, but also increases the penalty costs. The allocated capacity flexibilities are input (parameters) to the lower decision level, where the operational planning decisions are made and demands are observed. The simulation results reveal interesting managerial insights, such that the more uncertain outsourcer gets at least the same capacity flexibility allocated as the less uncertain outsourcer. Moreover, we have seen that when the acceptation decision is made, priority is given to the less uncertain outsourcer, because that information is the most valuable. However, we see the opposite effect when orders are placed, namely that priority is given to the more uncertain outsourcer, i.e., the most paying outsourcer, as no uncertainty is involved anymore. These insights are helpful for managers of contract manufacturers when having contract negotiations with the outsourcers. We believe that the results and insights that we obtained in the various research studies of this dissertation can contribute to solving the broader real-life problems related to the planning and control of outsourced supply chains. We also discuss potential managerial implications of our findings explicitly addressing the management decisions that may be affected by using the insights from our studies. Considering the operational implications of outsourcing when taking the strategic outsourcing decision will lead to a different and a better estimate of the transaction costs and probably to a different strategic outsourcing decision. Based on our research, we think that the transaction cost estimate will be higher if the outsourcer and the contract manufacturer do not agree on operational issues, such as the multi-level order release mechanism. From a tactical point of view, the outsourcer may include the options of postponement and cancellation in the contract, even if the contract manufacturer would charge little extra for these options. The results show that the benefits of including these options are substantial. Moreover, we showed that controlling a contract manufacturer operationally in the same way as an internal manufacturing source leads to a nervous ordering behaviour with a lot of changes and a lot of panicky communication between the outsourcer and the contract manufacturer. Combining the insights from different studies, one can also conclude that including little reservation cost is beneficial to both parties; it leads to a win-win situation. The outsourcer with a high level of demand uncertainty secures sufficient capacity allocation from the contract manufacturer and avoids more expensive penalty costs. For the outsourcer with less demand uncertainty, it is wise to set the contract such that the reservation costs are subtracted from the total paid amount. Moreover, this outsourcer may gain competitive advantage if his competitors operate in the same market by securing sufficient capacity allocation (by paying little reservation costs). For the contract manufacturer, including reservation cost is also beneficial, as it leads to a better match between the outsourcer’s reservation and ordering behaviour

Practices for strategic capacity management in Malaysian manufacturing firms

While the notion of manufacturing capabilities is a long-standing notion in research on operations management, its actual implementation and management has been hardly researched. Five case studies in Malaysia offered the opportunity to examine the practice of manufacturing managers with regard to strategic capability management. The data collection and analysis was structured by using the notion of Strategic Capacity Management. Whereas traditionally literature has demonstrated the beneficial impact of an appropriate manufacturing strategy on the business strategy and performance, the study highlights the difficulty of managers to set the strategy, let alone implementing it. This is partly caused by the immense pressure of customers in these dominantly Make-To-Order environments for SMEs. Current concepts for manufacturing capabilities have insufficiently accounted this phenomenon and an outline of a research agenda is presented