Compensation numérique pour convertisseur large bande hautement parallélisé.

Time-interleaved analog-to-digital converters (TIADC) seem to be the holy grail of analog-to-digital conversion. Theoretically, their sampling speed can be increased, very simply, by duplicating the sub-converters. The real world is different because mismatches between the converters strongly reduce the TIADC performance, especially when trying to push forward the sampling speed, or the resolution of the converter. Using background digital mismatch calibration can alleviate this limitation. The first part of the thesis is dedicated to studying the sources and effects of mismatches in a TIADC. Performance metrics such as the SNDR and the SFDR are derived as a function of the mismatch levels. In the second part, new background digital mismatch calibration techniques are presented. They are able to reduce the offset, gain, skew and bandwidth mismatch errors. The mismatches are estimated by using the statistical properties of the input signal and digital filters are used to reconstruct the correct output samples. In the third part, a 1.6 GS/s TIADC circuit, implementing offset, gain and skew mismatch calibration, demonstrates a reduction of the mismatch spurs down to a level of -70 dBFS, up to an input frequency of 750 MHz. The circuit achieves the lowest level of mismatches among TIADCs in the same frequency range, with a reasonable power and area, in spite of the overhead caused by the calibration.Les convertisseurs analogique-numérique à entrelacement temporel (TIADC) semblent être une solution prometteuse dans le monde de la conversion analogique-numérique. Leur fréquence d’échantillonnage peut théoriquement être augmentée en augmentant le nombre de convertisseurs en parallèle. En réalité, des désappariements entre les convertisseurs peuvent fortement dégrader les performances, particulièrement à haute fréquence d’échantillonnage ou à haute résolution. Ces défauts d’appariement peuvent être réduits en utilisant des techniques de calibration en arrière-plan. La première partie de cette thèse est consacrée à l’étude des sources et effets des différents types de désappariements dans un TIADC. Des indicateurs de performance tels que le SNDR ou la SFDR sont exprimés en fonction du niveau des désappariements. Dans la deuxième partie, des nouvelles techniques de calibration sont proposées. Ces techniques permettent de réduire les effets des désappariements d’offset, de gain, d’instant d’échantillonnage et de bande passante. Les désappariements sont estimés en se basant sur des propriétés statistiques du signal et la reconstruction des échantillons de sortie se fait en utilisant des filtres numériques. La troisième partie démontre les performance d’un TIADC fonctionnant a une fréquence d’échantillonnage de 1.6 GE/s et comprenant les calibration d’offset, de gain et d’instant d’échantillonnage proposées. Les raies fréquentielles dues aux désappariements sont réduites à un niveau de -70dBc jusqu’à une fréquence d’entrée de 750 MHz. Ce circuit démontre une meilleure correction de désappariements que des circuits similaires récemment publiés, et ce avec une augmentation de puissance consommée et de surface relativement faible

A portable device for time-resolved fluorescence based on an array of CMOS SPADs with integrated microfluidics

[eng] Traditionally, molecular analysis is performed in laboratories equipped with desktop instruments operated by specialized technicians. This paradigm has been changing in recent decades, as biosensor technology has become as accurate as desktop instruments, providing results in much shorter periods and miniaturizing the instrumentation, moving the diagnostic tests gradually out of the central laboratory. However, despite the inherent advantages of time-resolved fluorescence spectroscopy applied to molecular diagnosis, it is only in the last decade that POC (Point Of Care) devices have begun to be developed based on the detection of fluorescence, due to the challenge of developing high-performance, portable and low-cost spectroscopic sensors. This thesis presents the development of a compact, robust and low-cost system for molecular diagnosis based on time-resolved fluorescence spectroscopy, which serves as a general-purpose platform for the optical detection of a variety of biomarkers, bridging the gap between the laboratory and the POC of the fluorescence lifetime based bioassays. In particular, two systems with different levels of integration have been developed that combine a one-dimensional array of SPAD (Single-Photon Avalanch Diode) pixels capable of detecting a single photon, with an interchangeable microfluidic cartridge used to insert the sample and a laser diode Pulsed low-cost UV as a source of excitation. The contact-oriented design of the binomial formed by the sensor and the microfluidic, together with the timed operation of the sensors, makes it possible to dispense with the use of lenses and filters. In turn, custom packaging of the sensor chip allows the microfluidic cartridge to be positioned directly on the sensor array without any alignment procedure. Both systems have been validated, determining the decomposition time of quantum dots in 20 nl of solution for different concentrations, emulating a molecular test in a POC device.[cat] Tradicionalment, l'anàlisi molecular es realitza en laboratoris equipats amb instruments de sobretaula operats per tècnics especialitzats. Aquest paradigma ha anat canviant en les últimes dècades, a mesura que la tecnologia de biosensor s'ha tornat tan precisa com els instruments de sobretaula, proporcionant resultats en períodes molt més curts de temps i miniaturitzant la instrumentació, permetent així, traslladar gradualment les proves de diagnòstic fora de laboratori central. No obstant això i malgrat els avantatges inherents de l'espectroscòpia de fluorescència resolta en el temps aplicada a la diagnosi molecular, no ha estat fins a l'última dècada que s'han començat a desenvolupar dispositius POC (Point Of Care) basats en la detecció de la fluorescència, degut al desafiament que suposa el desenvolupament de sensors espectroscòpics d'alt rendiment, portàtils i de baix cost. Aquesta tesi presenta el desenvolupament d'un sistema compacte, robust i de baix cost per al diagnòstic molecular basat en l'espectroscòpia de fluorescència resolta en el temps, que serveixi com a plataforma d'ús general per a la detecció òptica d'una varietat de biomarcadors, tancant la bretxa entre el laboratori i el POC dels bioassaigs basats en l'anàlisi de la pèrdua de la fluorescència. En particular, s'han desenvolupat dos sistemes amb diferents nivells d'integració que combinen una matriu unidimensional de píxels SPAD (Single-Photon Avalanch Diode) capaços de detectar un sol fotó, amb un cartutx microfluídic intercanviable emprat per inserir la mostra, així com un díode làser UV premut de baix cost com a font d'excitació. El disseny orientat a la detecció per contacte de l'binomi format pel sensor i la microfluídica, juntament amb l'operació temporitzada dels sensors, permet prescindir de l'ús de lents i filtres. Al seu torn, l'empaquetat a mida de l'xip sensor permet posicionar el cartutx microfluídic directament sobre la matriu de sensors sense cap procediment d'alineament. Tots dos sistemes han estat validats determinant el temps de descomposició de "quantum dots" en 20 nl de solució per a diferents concentracions, emulant així un assaig molecular en un dispositiu POC

Spectroscopy and Dynamics of Transient Species, the Vinyl Radical and Highly Vibrationally Excited Acetylene

Time-resolved Fourier transform infra-red spectroscopy has been employed to identify vibrational modes of several transient molecular and radical species. IR emission from the vinyl radical generated by five different precursor molecules utilizing different dissociation pathways has been observed. An analytical method, two-dimensional cross spectral correlation, has been employed to verify the low energy bending modes of the vinyl radical as well as one stretching mode. Isotopic substitution has allowed several bending modes to be compared to their non-isotopically substituted analog. Highly vibrationally excited acetylene has also been generated via photochemical reaction. IR emission is modeled according to known harmonic and anharmonic terms of the linear ground electronic state of acetylene. An unexpectedly strong combination band is found in the modeling. Through collisionally induced vibrational energy transfer, energy transfer rates, collisional mass dependence, and the vibrational energy content of acetylene can be obtained. The production of highly vibrationally excited acetylene has presented the opportunity to study a short lived isomer of acetylene, vinylidene. The influence of vinylidene on acetylene is observed in the energy transfer rates at high energy. An enhancement in the energy transfer rate is observed above the acetylene-vinylidene isomerization barrier. An energy transfer model is used to verify this observation. A theoretical model is postulated which involves a mixing of vibrational states of acetylene and vinylidene above the isomerization barrier thus accounting for the enhancement of the energy transfer rate at high energies. Another method involving collisions between translationally hot hydrogen atoms and room temperature acetylene molecules generate a significant amount of vibrationally hot acetylene. Possible mechanisms are proposed and tested via isotopic substitution. A mechanism proceeding through a short lived vinyl intermediate dissociating to form a highly vibrationally excited acetylene molecule was found. A combined statistical/impulsive model and classical trajectory calculation confirm the production of a short lived vinyl radical intermediate