5,916 research outputs found

    Knowledge-based Biomedical Data Science 2019

    Full text link
    Knowledge-based biomedical data science (KBDS) involves the design and implementation of computer systems that act as if they knew about biomedicine. Such systems depend on formally represented knowledge in computer systems, often in the form of knowledge graphs. Here we survey the progress in the last year in systems that use formally represented knowledge to address data science problems in both clinical and biological domains, as well as on approaches for creating knowledge graphs. Major themes include the relationships between knowledge graphs and machine learning, the use of natural language processing, and the expansion of knowledge-based approaches to novel domains, such as Chinese Traditional Medicine and biodiversity.Comment: Manuscript 43 pages with 3 tables; Supplemental material 43 pages with 3 table

    Reasoning over Ontologies with Hidden Content: The Import-by-Query Approach

    Full text link
    There is currently a growing interest in techniques for hiding parts of the signature of an ontology Kh that is being reused by another ontology Kv. Towards this goal, in this paper we propose the import-by-query framework, which makes the content of Kh accessible through a limited query interface. If Kv reuses the symbols from Kh in a certain restricted way, one can reason over Kv U Kh by accessing only Kv and the query interface. We map out the landscape of the import-by-query problem. In particular, we outline the limitations of our framework and prove that certain restrictions on the expressivity of Kh and the way in which Kv reuses symbols from Kh are strictly necessary to enable reasoning in our setting. We also identify cases in which reasoning is possible and we present suitable import-by-query reasoning algorithms

    Infectious Disease Ontology

    Get PDF
    Technological developments have resulted in tremendous increases in the volume and diversity of the data and information that must be processed in the course of biomedical and clinical research and practice. Researchers are at the same time under ever greater pressure to share data and to take steps to ensure that data resources are interoperable. The use of ontologies to annotate data has proven successful in supporting these goals and in providing new possibilities for the automated processing of data and information. In this chapter, we describe different types of vocabulary resources and emphasize those features of formal ontologies that make them most useful for computational applications. We describe current uses of ontologies and discuss future goals for ontology-based computing, focusing on its use in the field of infectious diseases. We review the largest and most widely used vocabulary resources relevant to the study of infectious diseases and conclude with a description of the Infectious Disease Ontology (IDO) suite of interoperable ontology modules that together cover the entire infectious disease domain

    Evolutionary Subject Tagging in the Humanities; Supporting Discovery and Examination in Digital Cultural Landscapes

    Get PDF
    In this paper, the authors attempt to identify problematic issues for subject tagging in the humanities, particularly those associated with information objects in digital formats. In the third major section, the authors identify a number of assumptions that lie behind the current practice of subject classification that we think should be challenged. We move then to propose features of classification systems that could increase their effectiveness. These emerged as recurrent themes in many of the conversations with scholars, consultants, and colleagues. Finally, we suggest next steps that we believe will help scholars and librarians develop better subject classification systems to support research in the humanities.NEH Office of Digital Humanities: Digital Humanities Start-Up Grant (HD-51166-10

    An information model for computable cancer phenotypes

    Get PDF

    Critical Analysis of Clinical Document Clustering Technique with Special Reference to Non-Matrix Factorization

    Get PDF
    Clinical records containing significant prescription and side effect data, a huge number of documents are normally analyzed. A critical piece of the data in those reports contains unstructured substance, whose examination by PC assessors is difficult to be performed. We proposed a joining system for isolating medication names and sign names from clinical notes by applying Nonnegative Matrix Factorization (NMF) and multi-see NMF to bundle clinical notes into vital gatherings reliant on test incorporate networks. Our exploratory outcomes demonstrate that multi-see NMF is a best technique for clinical record bunching. In addition, we find that utilizing extricated prescription/side effect names to group clinical archives beats simply utilizing words. Bunching calculations are regularly utilized for exploratory information examination. Vast measure of information investigated
    • …
    corecore