Combinatorial CRISPR-Cas9 screens for de novo mapping of genetic interactions.

We developed a systematic approach to map human genetic networks by combinatorial CRISPR-Cas9 perturbations coupled to robust analysis of growth kinetics. We targeted all pairs of 73 cancer genes with dual guide RNAs in three cell lines, comprising 141,912 tests of interaction. Numerous therapeutically relevant interactions were identified, and these patterns replicated with combinatorial drugs at 75% precision. From these results, we anticipate that cellular context will be critical to synthetic-lethal therapies

Time-Space Efficient Regression Testing for Configurable Systems

Configurable systems are those that can be adapted from a set of options. They are prevalent and testing them is important and challenging. Existing approaches for testing configurable systems are either unsound (i.e., they can miss fault-revealing configurations) or do not scale. This paper proposes EvoSPLat, a regression testing technique for configurable systems. EvoSPLat builds on our previously-developed technique, SPLat, which explores all dynamically reachable configurations from a test. EvoSPLat is tuned for two scenarios of use in regression testing: Regression Configuration Selection (RCS) and Regression Test Selection (RTS). EvoSPLat for RCS prunes configurations (not tests) that are not impacted by changes whereas EvoSPLat for RTS prunes tests (not configurations) which are not impacted by changes. Handling both scenarios in the context of evolution is important. Experimental results show that EvoSPLat is promising. We observed a substantial reduction in time (22%) and in the number of configurations (45%) for configurable Java programs. In a case study on a large real-world configurable system (GCC), EvoSPLat reduced 35% of the running time. Comparing EvoSPLat with sampling techniques, 2-wise was the most efficient technique, but it missed two bugs whereas EvoSPLat detected all bugs four times faster than 6-wise, on average.Comment: 14 page

Automated analysis of feature models: Quo vadis?

Feature models have been used since the 90's to describe software product lines as a way of reusing common parts in a family of software systems. In 2010, a systematic literature review was published summarizing the advances and settling the basis of the area of Automated Analysis of Feature Models (AAFM). From then on, different studies have applied the AAFM in different domains. In this paper, we provide an overview of the evolution of this field since 2010 by performing a systematic mapping study considering 423 primary sources. We found six different variability facets where the AAFM is being applied that define the tendencies: product configuration and derivation; testing and evolution; reverse engineering; multi-model variability-analysis; variability modelling and variability-intensive systems. We also confirmed that there is a lack of industrial evidence in most of the cases. Finally, we present where and when the papers have been published and who are the authors and institutions that are contributing to the field. We observed that the maturity is proven by the increment in the number of journals published along the years as well as the diversity of conferences and workshops where papers are published. We also suggest some synergies with other areas such as cloud or mobile computing among others that can motivate further research in the future.Ministerio de Economía y Competitividad TIN2015-70560-RJunta de Andalucía TIC-186