Impact Assessment of Hypothesized Cyberattacks on Interconnected Bulk Power Systems

The first-ever Ukraine cyberattack on power grid has proven its devastation by hacking into their critical cyber assets. With administrative privileges accessing substation networks/local control centers, one intelligent way of coordinated cyberattacks is to execute a series of disruptive switching executions on multiple substations using compromised supervisory control and data acquisition (SCADA) systems. These actions can cause significant impacts to an interconnected power grid. Unlike the previous power blackouts, such high-impact initiating events can aggravate operating conditions, initiating instability that may lead to system-wide cascading failure. A systemic evaluation of "nightmare" scenarios is highly desirable for asset owners to manage and prioritize the maintenance and investment in protecting their cyberinfrastructure. This survey paper is a conceptual expansion of real-time monitoring, anomaly detection, impact analyses, and mitigation (RAIM) framework that emphasizes on the resulting impacts, both on steady-state and dynamic aspects of power system stability. Hypothetically, we associate the combinatorial analyses of steady state on substations/components outages and dynamics of the sequential switching orders as part of the permutation. The expanded framework includes (1) critical/noncritical combination verification, (2) cascade confirmation, and (3) combination re-evaluation. This paper ends with a discussion of the open issues for metrics and future design pertaining the impact quantification of cyber-related contingencies

Computational structure‐based drug design: Predicting target flexibility

The role of molecular modeling in drug design has experienced a significant revamp in the last decade. The increase in computational resources and molecular models, along with software developments, is finally introducing a competitive advantage in early phases of drug discovery. Medium and small companies with strong focus on computational chemistry are being created, some of them having introduced important leads in drug design pipelines. An important source for this success is the extraordinary development of faster and more efficient techniques for describing flexibility in three‐dimensional structural molecular modeling. At different levels, from docking techniques to atomistic molecular dynamics, conformational sampling between receptor and drug results in improved predictions, such as screening enrichment, discovery of transient cavities, etc. In this review article we perform an extensive analysis of these modeling techniques, dividing them into high and low throughput, and emphasizing in their application to drug design studies. We finalize the review with a section describing our Monte Carlo method, PELE, recently highlighted as an outstanding advance in an international blind competition and industrial benchmarks.We acknowledge the BSC-CRG-IRB Joint Research Program in Computational Biology. This work was supported by a grant from the Spanish Government CTQ2016-79138-R.J.I. acknowledges support from SVP-2014-068797, awarded by the Spanish Government.Peer ReviewedPostprint (author's final draft

An Assessment of PIER Electric Grid Research 2003-2014 White Paper

This white paper describes the circumstances in California around the turn of the 21st century that led the California Energy Commission (CEC) to direct additional Public Interest Energy Research funds to address critical electric grid issues, especially those arising from integrating high penetrations of variable renewable generation with the electric grid. It contains an assessment of the beneficial science and technology advances of the resultant portfolio of electric grid research projects administered under the direction of the CEC by a competitively selected contractor, the University of California’s California Institute for Energy and the Environment, from 2003-2014

Selection of Line Contingency for Power System Security Analysis

Contingency analysis (CA) has always been an in integral part of power system security analysis. CA is a useful tool at disposal of operation personnel to see effects of future outages on the system. The overload Performance Index (PI) is a good index for ranking the contingencies as per their severity. The PI requires “n” number of DC analysis to create a complete index, where n is no of lines. And for a larger network having a higher multitude of lines, it is time consuming. A new approach has been discussed for ranking the contingencies. This method requires one DC analysis and line outage distribution factor, which is constant for a particular unchanged transmission network