Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels

Artificial intelligence (AI) can identify actionable oncology biomarkers. This research integrates our previous analyses of non-Hodgkin lymphoma. We used gene expression and immunohistochemical data, focusing on the immune checkpoint, and added a new analysis of macrophages, including 3D rendering. The AI comprised machine learning (C5, Bayesian network, C&R, CHAID, discriminant analysis, KNN, logistic regression, LSVM, Quest, random forest, random trees, SVM, tree-AS, and XGBoost linear and tree) and artificial neural networks (multilayer perceptron and radial basis function). The series included chronic lymphocytic leukemia, mantle cell lymphoma, follicular lymphoma, Burkitt, diffuse large B-cell lymphoma, marginal zone lymphoma, and multiple myeloma, as well as acute myeloid leukemia and pan-cancer series. AI classified lymphoma subtypes and predicted overall survival accurately. Oncogenes and tumor suppressor genes were highlighted (MYC, BCL2, and TP53), along with immune microenvironment markers of tumor-associated macrophages (M2-like TAMs), T-cells and regulatory T lymphocytes (Tregs) (CD68, CD163, MARCO, CSF1R, CSF1, PD-L1/CD274, SIRPA, CD85A/LILRB3, CD47, IL10, TNFRSF14/HVEM, TNFAIP8, IKAROS, STAT3, NFKB, MAPK, PD-1/PDCD1, BTLA, and FOXP3), apoptosis (BCL2, CASP3, CASP8, PARP, and pathway-related MDM2, E2F1, CDK6, MYB, and LMO2), and metabolism (ENO3, GGA3). In conclusion, AI with immuno-oncology markers is a powerful predictive tool. Additionally, a review of recent literature was made

Forecasting Automobile Demand Via Artificial Neural Networks & Neuro-Fuzzy Systems

The objective of this research is to obtain an accurate forecasting model for the demand for automobiles in Iran\u27s domestic market. The model is constructed using production data for vehicles manufactured from 2006 to 2016, by Iranian car makers. The increasing demand for transportation and automobiles in Iran necessitated an accurate forecasting model for car manufacturing companies in Iran so that future demand is met. Demand is deduced as a function of the historical data. The monthly gold, rubber, and iron ore prices along with the monthly commodity metals price index and the Stock index of Iran are Artificial neural network (ANN) and artificial neuro-fuzzy system (ANFIS) have been utilized in many fields such as energy consumption and load forecasting fields. The performances of the methodologies are investigated towards obtaining the most accurate forecasting model in terms of the forecast Mean Absolute Percentage Error (MAPE). It was concluded that the feedforward multi-layer perceptron network with back-propagation and the Levenberg-Marquardt learning algorithm provides forecasts with the lowest MAPE (5.85%) among the other models. Further development of the ANN network based on more data is recommended to enhance the model and obtain more accurate networks and subsequently improved forecasts

An Overview of Forecasting Methods for Monthly Electricity Consumption

Mid-term electricity consumption forecasting is analysed in this paper. Forecasting of electricity consumption is regression problem that can be defined as using previous consumption of an individual or a group with the goal of calculation of future consumption using some mathematical or statistical approach. The purpose of this prediction is multi beneficial to the stakeholders in the energy community, since this information can affect production, sales and supply. The Different methods are considered with the main goal to determine the best forecasting model. Considered methods include Box-Jenkins autoregressive integrated moving average models, state-space models and exponential smoothing, and machine learning methods including neural networks. An additional objective of the conducted research was to determine if modern methods like machine learning are equally precise in forecasting mid-term electricity consumption when compared to traditional time series methods. The performances of forecasting models are evaluated on the monthly electricity consumption data obtained using real billing software owned by the Distribution System Operator in Bosnia and Herzegovina. Mean absolute percentage error is selected as a measure of prediction accuracy of forecasting methods. Every forecasting method is implemented and tested using the R language, while data is collected from Data Warehouse in the form of total monthly consumption. The efficiency of presented solution will also be discussed after presentation of the results

Artificial Intelligence Analysis of the Gene Expression of Follicular Lymphoma Predicted the Overall Survival and Correlated with the Immune Microenvironment Response Signatures

Follicular lymphoma (FL) is the second most common lymphoma in Western countries. FL is characterized by being incurable, usually having an indolent clinical course with frequent relapses, and an eventual patient’s death or transformation to Diffuse Large B-cell Lymphoma. The immune response and the tumoral immune microenvironment, including FOXP3+Tregs, PD-1+TFH cells, TNFRSF14 (HVEM), and BTLA play a role in the pathogenesis. We aimed to analyze the gene expression of FL by Artificial Intelligence (machine learning, deep learning), to identify genes associated with the prognosis of the patients and with the microenvironment in terms of overall survival (OS). A series of 184 cases of the GSE16131 dataset was analyzed by multilayer perceptron (MLP) and radial basis function (RBF) neural networks. In the analysis, MLP and RBF had a synergistic effect. From an initial set of 22,215 genes probes, a final set of 43 genes was highlighted. These 43 genes predicted the OS and correlated with the immune microenvironment: in a multivariate Cox analysis, 18 genes were associated with a poor prognosis (namely, MED8, KRT19, CDC40, SLC24A2, PRB1, KIAA0100, EVA1B, KLK10, TMEM70, BTN2A3P, TRPM4, MED6, FRYL, CBFA2T2, RANBP9, BNIP2, PTP4A2 and ALDH1L1) and 25 genes were associated with a good prognosis of the patients. Gene set enrichment analysis (GSEA) confirmed these findings and showed a typical sinusoidal-like shape. Some of the most relevant genes for poor OS were EVA1B, KRT19, BTN2A3P, KLK10, TRPM4, TMEM70, and SLC24A2 (hazard risk = from 1.7 to 4.3, p < 0.005) and for good OS, these were TDRD12 and ZNF230 (HR = 0.34 and 0.28, p < 0.001). EVA1B, KRT19, BTN2AP3, KLK10, and TRPM4 also associated with M2-like macrophage markers including CD163, MRC1 (CD206), and IL10 in the core enrichment for dead OS outcome by GSEA and to poor OS by Kaplan–Meier with Log rank test. The scientific literature showed that some of these genes also play a role in other types of cancer. In conclusion, by Artificial Intelligence, we have identified new biomarkers with prognostic relevance in FL

Applications of fuzzy counterpropagation neural networks to non-linear function approximation and background noise elimination

An adaptive filter which can operate in an unknown environment by performing a learning mechanism that is suitable for the speech enhancement process. This research develops a novel ANN model which incorporates the fuzzy set approach and which can perform a non-linear function approximation. The model is used as the basic structure of an adaptive filter. The learning capability of ANN is expected to be able to reduce the development time and cost of the designing adaptive filters based on fuzzy set approach. A combination of both techniques may result in a learnable system that can tackle the vagueness problem of a changing environment where the adaptive filter operates. This proposed model is called Fuzzy Counterpropagation Network (Fuzzy CPN). It has fast learning capability and self-growing structure. This model is applied to non-linear function approximation, chaotic time series prediction and background noise elimination

A Survey on Distributed Fibre Optic Sensor Data Modelling Techniques and Machine Learning Algorithms for Multiphase Fluid Flow Estimation

Real-time monitoring of multiphase fluid flows with distributed fibre optic sensing has the potential to play a major role in industrial flow measurement applications. One such application is the optimization of hydrocarbon production to maximize short-term income, and prolong the operational lifetime of production wells and the reservoir. While the measurement technology itself is well understood and developed, a key remaining challenge is the establishment of robust data analysis tools that are capable of providing real-time conversion of enormous data quantities into actionable process indicators. This paper provides a comprehensive technical review of the data analysis techniques for distributed fibre optic technologies, with a particular focus on characterizing fluid flow in pipes. The review encompasses classical methods, such as the speed of sound estimation and Joule-Thomson coefficient, as well as their data-driven machine learning counterparts, such as Convolutional Neural Network (CNN), Support Vector Machine (SVM), and Ensemble Kalman Filter (EnKF) algorithms. The study aims to help end-users establish reliable, robust, and accurate solutions that can be deployed in a timely and effective way, and pave the wave for future developments in the field.publishedVersio