A Tissue Engineering product development pathway

Tissue engineering is a field of inquiry and research that uses engineering techniques and principles of biological sciences to develop functional substitutes for reconstruction of damaged organs. Commercial translation of tissue engineering products is currently in progress all over the world. Many companies are moving their interest towards this market segment that grows by 6% per year. Aim of this thesis is to probe the possibility of developing tissue engineering products in the most cost-effective way, minimizing the industrial risk and developing a specific fund raising model. Tissue engineering is based on three main features: cells, scaffolds and bioreactors. Cells are seeded on a scaffold and cultured in a bioreactor in order to obtain a tissue engineering product. Nevertheless, developing cell carrying products is hampered by certification claims ("advanced therapies" certification rules) that unbearably increase R&D and certification costs and can be faced by either big companies or start-ups of big companies and spin-offs of complex aggregates of research centers involved in advanced cell research. On the other hand, scaffolds (certification class IIb) and bioreactors for tissue engineering (certification class I) can be developed with a lower economic effort, being the competition based on innovation, since their market is in the "growth phase" for scaffolds and in the "introduction phase" for bioreactors in the Levitt's product life cycle theory. Purpose of this thesis is to basically study scaffold and bioreactor features, then to preliminarily design some models of bioreactors and, eventually, to set a business model, based on private and public fund raising, aimed to the development of scaffolds for dental implantology and of bioreactors for cardiovascular and bone tissue engineering. Finally, a business plan of a company being spin-off of Politecnico di Torino and industrial start-up has been elaborate

Shuttle/GPSPAC experimentation study

The utilization is discussed of the GPSPAC, which is presently being developed to be used on the low altitude host vehicle (LAHV), for possible use in the shuttle avionics system to evaluate shuttle/GPS navigation performance. Analysis and tradeoffs of the shuttle/GPS link, shuttle signal interface requirements, oscillator tradeoffs and GPSPAC mechanical modifications for shuttle are included. Only the on-orbit utilization of GPSPAC for the shuttle is discussed. Other phases are briefly touched upon. Recommendations are provided for using the present GPSPAC and the changes required to perform shuttle on-orbit navigation

Forum Session at the First International Conference on Service Oriented Computing (ICSOC03)

The First International Conference on Service Oriented Computing (ICSOC) was held in Trento, December 15-18, 2003. The focus of the conference ---Service Oriented Computing (SOC)--- is the new emerging paradigm for distributed computing and e-business processing that has evolved from object-oriented and component computing to enable building agile networks of collaborating business applications distributed within and across organizational boundaries. Of the 181 papers submitted to the ICSOC conference, 10 were selected for the forum session which took place on December the 16th, 2003. The papers were chosen based on their technical quality, originality, relevance to SOC and for their nature of being best suited for a poster presentation or a demonstration. This technical report contains the 10 papers presented during the forum session at the ICSOC conference. In particular, the last two papers in the report ere submitted as industrial papers

Data management study, volume 5. Appendix A - Contractor data package technical description and system engineering /SE/ Final report

Technical description and systems engineering contractor data package for Voyager spacecraf

Payload missions integration

Payload mission integration is summarized. Activities and achievements for Spacelab OSTA and OSS are discussed

A study of concept options for the evolution of Space Station Freedom

Two conceptual evolution configurations for Space Station Freedom, a research and development configuration, and a transportation node configuration are described and analyzed. Results of pertinent analyses of mass properties, attitude control, microgravity, orbit lifetime, and reboost requirements are provided along with a description of these analyses. Also provided are brief descriptions of the elements and systems that comprise these conceptual configurations

Development of a color display capability

Color display capabilities for digital computer

Sustainable Waste Sorter

Indiana University Purdue University IndianapolisThe purpose of this project is to help people eliminate the confusion on whether they should throw their trash away or dispose of it in a recycling bin. The sustainable waste sorter is an informative device that tells the user where to place their trash. Our customer and the origin of the idea came from an organization called Roche Diagnostics Operations. Roche Diagnostics Operations is a multinational healthcare organization, the Indianapolis location focuses more on creating and developing their diabetic test strips. The device is created of four main components which include a Raspberry Pi 2 Model B, a camera module, an LCD screen, and a casing/mount that holds all of these components together. All of these components are compatible with the Raspberry Pi 2 Model B. The software was programmed in Python and the database in MySQL. During the development of the device, the most challenging task was learning how to develop in the new language, Python. Once the device reached a stable state it was piloted at Roche Diagnostics Operations. The purpose of the first of three pilot sessions was to verify that the device worked in the environment and that the items entered in the database were recognized; as a result, the device passed that test. The second pilot session had the same purpose as the first pilot session but with more items in the database. The device received more interaction during the second pilot session, though the team decided to schedule a third pilot session once all the items were entered into the database and a revamped user interface was completed. The team entered about 800 entries into the database and created a new and interactive user interface for the device. The third pilot session was a success; the items that were scanned by testers were recognized and the new user interface was a success as well. Overall, the sustainable waste sorter project was successful and educational. We, as students, took all of our fundamental learnings from our previous courses and applied them to this project. This allowed us to enhance our problem solving and project management skills. As people use the device, we hope that it educates them on how to properly recycle therefore improving the environmental state of our planet.Computer Engineering Technolog

A Dynamic Knowledge Management Framework for the High Value Manufacturing Industry

Dynamic Knowledge Management (KM) is a combination of cultural and technological factors, including the cultural factors of people and their motivations, technological factors of content and infrastructure and, where these both come together, interface factors. In this paper a Dynamic KM framework is described in the context of employees being motivated to create profit for their company through product development in high value manufacturing. It is reported how the framework was discussed during a meeting of the collaborating company’s (BAE Systems) project stakeholders. Participants agreed the framework would have most benefit at the start of the product lifecycle before key decisions were made. The framework has been designed to support organisational learning and to reward employees that improve the position of the company in the market place