From Affective Science to Psychiatric Disorder: Ontology as Semantic Bridge

Advances in emotion and affective science have yet to translate routinely into psychiatric research and practice. This is unfortunate since emotion and affect are fundamental components of many psychiatric conditions. Rectifying this lack of interdisciplinary integration could thus be a potential avenue for improving psychiatric diagnosis and treatment. In this contribution, we propose and discuss an ontological framework for explicitly capturing the complex interrelations between affective entities and psychiatric disorders, in order to facilitate mapping and integration between affective science and psychiatric diagnostics. We build on and enhance the categorisation of emotion, affect and mood within the previously developed Emotion Ontology, and that of psychiatric disorders in the Mental Disease Ontology. This effort further draws on developments in formal ontology regarding the distinction between normal and abnormal in order to formalize the interconnections. This operational semantic framework is relevant for applications including clarifying psychiatric diagnostic categories, clinical information systems, and the integration and translation of research results across disciplines

Description and Experience of the Clinical Testbeds

This deliverable describes the up-to-date technical environment at three clinical testbed demonstrator sites of the 6WINIT Project, including the adapted clinical applications, project components and network transition technologies in use at these sites after 18 months of the Project. It also provides an interim description of early experiences with deployment and usage of these applications, components and technologies, and their clinical service impact

Federated learning for medical imaging radiology

Federated learning (FL) is gaining wide acceptance across the medical AI domains. FL promises to provide a fairly acceptable clinical-grade accuracy, privacy, and generalisability of machine learning models across multiple institutions. However, the research on FL for medical imaging AI is still in its early stages. This paper presents a review of recent research to outline the difference between state-of-the-art [SOTA] (published literature) and state-of-the-practice [SOTP] (applied research in realistic clinical environments). Furthermore, the review outlines the future research directions considering various factors such as data, learning models, system design, governance, and human-in-loop to translate the SOTA into SOTP and effectively collaborate across multiple institutions

Data analytics and algorithms in policing in England and Wales: Towards a new policy framework

RUSI was commissioned by the Centre for Data Ethics and Innovation (CDEI) to conduct an independent study into the use of data analytics by police forces in England and Wales, with a focus on algorithmic bias. The primary purpose of the project is to inform CDEI’s review of bias in algorithmic decision-making, which is focusing on four sectors, including policing, and working towards a draft framework for the ethical development and deployment of data analytics tools for policing. This paper focuses on advanced algorithms used by the police to derive insights, inform operational decision-making or make predictions. Biometric technology, including live facial recognition, DNA analysis and fingerprint matching, are outside the direct scope of this study, as are covert surveillance capabilities and digital forensics technology, such as mobile phone data extraction and computer forensics. However, because many of the policy issues discussed in this paper stem from general underlying data protection and human rights frameworks, these issues will also be relevant to other police technologies, and their use must be considered in parallel to the tools examined in this paper. The project involved engaging closely with senior police officers, government officials, academics, legal experts, regulatory and oversight bodies and civil society organisations. Sixty nine participants took part in the research in the form of semi-structured interviews, focus groups and roundtable discussions. The project has revealed widespread concern across the UK law enforcement community regarding the lack of official national guidance for the use of algorithms in policing, with respondents suggesting that this gap should be addressed as a matter of urgency. Any future policy framework should be principles-based and complement existing police guidance in a ‘tech-agnostic’ way. Rather than establishing prescriptive rules and standards for different data technologies, the framework should establish standardised processes to ensure that data analytics projects follow recommended routes for the empirical evaluation of algorithms within their operational context and evaluate the project against legal requirements and ethical standards. The new guidance should focus on ensuring multi-disciplinary legal, ethical and operational input from the outset of a police technology project; a standard process for model development, testing and evaluation; a clear focus on the human–machine interaction and the ultimate interventions a data driven process may inform; and ongoing tracking and mitigation of discrimination risk

Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex.

Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host's immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as 'key players' within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD