26,458 research outputs found
How will the Internet of Things enable Augmented Personalized Health?
Internet-of-Things (IoT) is profoundly redefining the way we create, consume,
and share information. Health aficionados and citizens are increasingly using
IoT technologies to track their sleep, food intake, activity, vital body
signals, and other physiological observations. This is complemented by IoT
systems that continuously collect health-related data from the environment and
inside the living quarters. Together, these have created an opportunity for a
new generation of healthcare solutions. However, interpreting data to
understand an individual's health is challenging. It is usually necessary to
look at that individual's clinical record and behavioral information, as well
as social and environmental information affecting that individual. Interpreting
how well a patient is doing also requires looking at his adherence to
respective health objectives, application of relevant clinical knowledge and
the desired outcomes.
We resort to the vision of Augmented Personalized Healthcare (APH) to exploit
the extensive variety of relevant data and medical knowledge using Artificial
Intelligence (AI) techniques to extend and enhance human health to presents
various stages of augmented health management strategies: self-monitoring,
self-appraisal, self-management, intervention, and disease progress tracking
and prediction. kHealth technology, a specific incarnation of APH, and its
application to Asthma and other diseases are used to provide illustrations and
discuss alternatives for technology-assisted health management. Several
prominent efforts involving IoT and patient-generated health data (PGHD) with
respect converting multimodal data into actionable information (big data to
smart data) are also identified. Roles of three components in an evidence-based
semantic perception approach- Contextualization, Abstraction, and
Personalization are discussed
Use of nonintrusive sensor-based information and communication technology for real-world evidence for clinical trials in dementia
Cognitive function is an important end point of treatments in dementia clinical trials. Measuring cognitive function by standardized tests, however, is biased toward highly constrained environments (such as hospitals) in selected samples. Patient-powered real-world evidence using information and communication technology devices, including environmental and wearable sensors, may help to overcome these limitations. This position paper describes current and novel information and communication technology devices and algorithms to monitor behavior and function in people with prodromal and manifest stages of dementia continuously, and discusses clinical, technological, ethical, regulatory, and user-centered requirements for collecting real-world evidence in future randomized controlled trials. Challenges of data safety, quality, and privacy and regulatory requirements need to be addressed by future smart sensor technologies. When these requirements are satisfied, these technologies will provide access to truly user relevant outcomes and broader cohorts of participants than currently sampled in clinical trials
Beyond Volume: The Impact of Complex Healthcare Data on the Machine Learning Pipeline
From medical charts to national census, healthcare has traditionally operated
under a paper-based paradigm. However, the past decade has marked a long and
arduous transformation bringing healthcare into the digital age. Ranging from
electronic health records, to digitized imaging and laboratory reports, to
public health datasets, today, healthcare now generates an incredible amount of
digital information. Such a wealth of data presents an exciting opportunity for
integrated machine learning solutions to address problems across multiple
facets of healthcare practice and administration. Unfortunately, the ability to
derive accurate and informative insights requires more than the ability to
execute machine learning models. Rather, a deeper understanding of the data on
which the models are run is imperative for their success. While a significant
effort has been undertaken to develop models able to process the volume of data
obtained during the analysis of millions of digitalized patient records, it is
important to remember that volume represents only one aspect of the data. In
fact, drawing on data from an increasingly diverse set of sources, healthcare
data presents an incredibly complex set of attributes that must be accounted
for throughout the machine learning pipeline. This chapter focuses on
highlighting such challenges, and is broken down into three distinct
components, each representing a phase of the pipeline. We begin with attributes
of the data accounted for during preprocessing, then move to considerations
during model building, and end with challenges to the interpretation of model
output. For each component, we present a discussion around data as it relates
to the healthcare domain and offer insight into the challenges each may impose
on the efficiency of machine learning techniques.Comment: Healthcare Informatics, Machine Learning, Knowledge Discovery: 20
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Natural Language Processing of Clinical Notes on Chronic Diseases: Systematic Review
Novel approaches that complement and go beyond evidence-based medicine are required in the domain of chronic diseases, given the growing incidence of such conditions on the worldwide population. A promising avenue is the secondary use of electronic health records (EHRs), where patient data are analyzed to conduct clinical and translational research. Methods based on machine learning to process EHRs are resulting in improved understanding of patient clinical trajectories and chronic disease risk prediction, creating a unique opportunity to derive previously unknown clinical insights. However, a wealth of clinical histories remains locked behind clinical narratives in free-form text. Consequently, unlocking the full potential of EHR data is contingent on the development of natural language processing (NLP) methods to automatically transform clinical text into structured clinical data that can guide clinical decisions and potentially delay or prevent disease onset
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