Machine Learning and Integrative Analysis of Biomedical Big Data.

Recent developments in high-throughput technologies have accelerated the accumulation of massive amounts of omics data from multiple sources: genome, epigenome, transcriptome, proteome, metabolome, etc. Traditionally, data from each source (e.g., genome) is analyzed in isolation using statistical and machine learning (ML) methods. Integrative analysis of multi-omics and clinical data is key to new biomedical discoveries and advancements in precision medicine. However, data integration poses new computational challenges as well as exacerbates the ones associated with single-omics studies. Specialized computational approaches are required to effectively and efficiently perform integrative analysis of biomedical data acquired from diverse modalities. In this review, we discuss state-of-the-art ML-based approaches for tackling five specific computational challenges associated with integrative analysis: curse of dimensionality, data heterogeneity, missing data, class imbalance and scalability issues

Understanding and Comparing Scalable Gaussian Process Regression for Big Data

As a non-parametric Bayesian model which produces informative predictive distribution, Gaussian process (GP) has been widely used in various fields, like regression, classification and optimization. The cubic complexity of standard GP however leads to poor scalability, which poses challenges in the era of big data. Hence, various scalable GPs have been developed in the literature in order to improve the scalability while retaining desirable prediction accuracy. This paper devotes to investigating the methodological characteristics and performance of representative global and local scalable GPs including sparse approximations and local aggregations from four main perspectives: scalability, capability, controllability and robustness. The numerical experiments on two toy examples and five real-world datasets with up to 250K points offer the following findings. In terms of scalability, most of the scalable GPs own a time complexity that is linear to the training size. In terms of capability, the sparse approximations capture the long-term spatial correlations, the local aggregations capture the local patterns but suffer from over-fitting in some scenarios. In terms of controllability, we could improve the performance of sparse approximations by simply increasing the inducing size. But this is not the case for local aggregations. In terms of robustness, local aggregations are robust to various initializations of hyperparameters due to the local attention mechanism. Finally, we highlight that the proper hybrid of global and local scalable GPs may be a promising way to improve both the model capability and scalability for big data.Comment: 25 pages, 15 figures, preprint submitted to KB

A Review on Energy Consumption Optimization Techniques in IoT Based Smart Building Environments

In recent years, due to the unnecessary wastage of electrical energy in residential buildings, the requirement of energy optimization and user comfort has gained vital importance. In the literature, various techniques have been proposed addressing the energy optimization problem. The goal of each technique was to maintain a balance between user comfort and energy requirements such that the user can achieve the desired comfort level with the minimum amount of energy consumption. Researchers have addressed the issue with the help of different optimization algorithms and variations in the parameters to reduce energy consumption. To the best of our knowledge, this problem is not solved yet due to its challenging nature. The gap in the literature is due to the advancements in the technology and drawbacks of the optimization algorithms and the introduction of different new optimization algorithms. Further, many newly proposed optimization algorithms which have produced better accuracy on the benchmark instances but have not been applied yet for the optimization of energy consumption in smart homes. In this paper, we have carried out a detailed literature review of the techniques used for the optimization of energy consumption and scheduling in smart homes. The detailed discussion has been carried out on different factors contributing towards thermal comfort, visual comfort, and air quality comfort. We have also reviewed the fog and edge computing techniques used in smart homes

Integration of perception and reasoning in fast neural modules

Artificial neural systems promise to integrate symbolic and sub-symbolic processing to achieve real time control of physical systems. Two potential alternatives exist. In one, neural nets can be used to front-end expert systems. The expert systems, in turn, are developed with varying degrees of parallelism, including their implementation in neural nets. In the other, rule-based reasoning and sensor data can be integrated within a single hybrid neural system. The hybrid system reacts as a unit to provide decisions (problem solutions) based on the simultaneous evaluation of data and rules. Discussed here is a model hybrid system based on the fuzzy cognitive map (FCM). The operation of the model is illustrated with the control of a hypothetical satellite that intelligently alters its attitude in space in response to an intersecting micrometeorite shower

apk2vec: Semi-supervised multi-view representation learning for profiling Android applications

Building behavior profiles of Android applications (apps) with holistic, rich and multi-view information (e.g., incorporating several semantic views of an app such as API sequences, system calls, etc.) would help catering downstream analytics tasks such as app categorization, recommendation and malware analysis significantly better. Towards this goal, we design a semi-supervised Representation Learning (RL) framework named apk2vec to automatically generate a compact representation (aka profile/embedding) for a given app. More specifically, apk2vec has the three following unique characteristics which make it an excellent choice for largescale app profiling: (1) it encompasses information from multiple semantic views such as API sequences, permissions, etc., (2) being a semi-supervised embedding technique, it can make use of labels associated with apps (e.g., malware family or app category labels) to build high quality app profiles, and (3) it combines RL and feature hashing which allows it to efficiently build profiles of apps that stream over time (i.e., online learning). The resulting semi-supervised multi-view hash embeddings of apps could then be used for a wide variety of downstream tasks such as the ones mentioned above. Our extensive evaluations with more than 42,000 apps demonstrate that apk2vec's app profiles could significantly outperform state-of-the-art techniques in four app analytics tasks namely, malware detection, familial clustering, app clone detection and app recommendation.Comment: International Conference on Data Mining, 201