Acetylcholine neuromodulation in normal and abnormal learning and memory: vigilance control in waking, sleep, autism, amnesia, and Alzheimer's disease

This article provides a unified mechanistic neural explanation of how learning, recognition, and cognition break down during Alzheimer's disease, medial temporal amnesia, and autism. It also clarifies whey there are often sleep disturbances during these disorders. A key mechanism is how acetylcholine modules vigilance control in cortical layer

ARTMAP-IC and Medical Diagnosis: Instance Counting and Inconsistent Cases

For complex database prediction problems such as medical diagnosis, the ARTMAP-IC neural network adds distributed prediction and category instance counting to the basic fuzzy ARTMAP system. For the ARTMAP match tracking algorithm, which controls search following a predictive error, a new version facilitates prediction with sparse or inconsistent data. Compared to the original match tracking algorithm (MT+), the new algorithm (MT-) better approximates the real-time network differential equations and further compresses memory without loss of performance. Simulations examine predictive accuracy on four medical databases: Pima Indian diabetes, breast cancer, heart disease, and gall bladder removal. ARTMAP-IC results arc equal to or better than those of logistic regression, K nearest neighbor (KNN), the ADAP perceptron, multisurface pattern separation, CLASSIT, instance-based (IBL), and C4. ARTMAP dynamics are fast, stable, and scalable. A voting strategy improves prediction by training the system several times on different orderings of an input set. Voting, instance counting, and distributed representations combine to form confidence estimates for competing predictions.National Science Foundation (IRI 94-01659); Office of Naval Research (N00014-95-J-0409, N00014-95-0657

Neural Networks for Modeling and Control of Particle Accelerators

We describe some of the challenges of particle accelerator control, highlight recent advances in neural network techniques, discuss some promising avenues for incorporating neural networks into particle accelerator control systems, and describe a neural network-based control system that is being developed for resonance control of an RF electron gun at the Fermilab Accelerator Science and Technology (FAST) facility, including initial experimental results from a benchmark controller.Comment: 21 p

Structural, item, and test generalizability of the psychopathology checklist - revised to offenders with intellectual disabilities

The Psychopathy Checklist–Revised (PCL-R) is the most widely used measure of psychopathy in forensic clinical practice, but the generalizability of the measure to offenders with intellectual disabilities (ID) has not been clearly established. This study examined the structural equivalence and scalar equivalence of the PCL-R in a sample of 185 male offenders with ID in forensic mental health settings, as compared with a sample of 1,212 male prisoners without ID. Three models of the PCL-R’s factor structure were evaluated with confirmatory factor analysis. The 3-factor hierarchical model of psychopathy was found to be a good fit to the ID PCL-R data, whereas neither the 4-factor model nor the traditional 2-factor model fitted. There were no cross-group differences in the factor structure, providing evidence of structural equivalence. However, item response theory analyses indicated metric differences in the ratings of psychopathy symptoms between the ID group and the comparison prisoner group. This finding has potential implications for the interpretation of PCL-R scores obtained with people with ID in forensic psychiatric settings

Automatic Construction of Predictive Neuron Models through Large Scale Assimilation of Electrophysiological Data.

We report on the construction of neuron models by assimilating electrophysiological data with large-scale constrained nonlinear optimization. The method implements interior point line parameter search to determine parameters from the responses to intracellular current injections of zebra finch HVC neurons. We incorporated these parameters into a nine ionic channel conductance model to obtain completed models which we then use to predict the state of the neuron under arbitrary current stimulation. Each model was validated by successfully predicting the dynamics of the membrane potential induced by 20-50 different current protocols. The dispersion of parameters extracted from different assimilation windows was studied. Differences in constraints from current protocols, stochastic variability in neuron output, and noise behave as a residual temperature which broadens the global minimum of the objective function to an ellipsoid domain whose principal axes follow an exponentially decaying distribution. The maximum likelihood expectation of extracted parameters was found to provide an excellent approximation of the global minimum and yields highly consistent kinetics for both neurons studied. Large scale assimilation absorbs the intrinsic variability of electrophysiological data over wide assimilation windows. It builds models in an automatic manner treating all data as equal quantities and requiring minimal additional insight

The State-of-the-art of Coordinated Ramp Control with Mixed Traffic Conditions

Ramp metering, a traditional traffic control strategy for conventional vehicles, has been widely deployed around the world since the 1960s. On the other hand, the last decade has witnessed significant advances in connected and automated vehicle (CAV) technology and its great potential for improving safety, mobility and environmental sustainability. Therefore, a large amount of research has been conducted on cooperative ramp merging for CAVs only. However, it is expected that the phase of mixed traffic, namely the coexistence of both human-driven vehicles and CAVs, would last for a long time. Since there is little research on the system-wide ramp control with mixed traffic conditions, the paper aims to close this gap by proposing an innovative system architecture and reviewing the state-of-the-art studies on the key components of the proposed system. These components include traffic state estimation, ramp metering, driving behavior modeling, and coordination of CAVs. All reviewed literature plot an extensive landscape for the proposed system-wide coordinated ramp control with mixed traffic conditions.Comment: 8 pages, 1 figure, IEEE INTELLIGENT TRANSPORTATION SYSTEMS CONFERENCE - ITSC 201

Vision-Based Lane-Changing Behavior Detection Using Deep Residual Neural Network

Accurate lane localization and lane change detection are crucial in advanced driver assistance systems and autonomous driving systems for safer and more efficient trajectory planning. Conventional localization devices such as Global Positioning System only provide road-level resolution for car navigation, which is incompetent to assist in lane-level decision making. The state of art technique for lane localization is to use Light Detection and Ranging sensors to correct the global localization error and achieve centimeter-level accuracy, but the real-time implementation and popularization for LiDAR is still limited by its computational burden and current cost. As a cost-effective alternative, vision-based lane change detection has been highly regarded for affordable autonomous vehicles to support lane-level localization. A deep learning-based computer vision system is developed to detect the lane change behavior using the images captured by a front-view camera mounted on the vehicle and data from the inertial measurement unit for highway driving. Testing results on real-world driving data have shown that the proposed method is robust with real-time working ability and could achieve around 87% lane change detection accuracy. Compared to the average human reaction to visual stimuli, the proposed computer vision system works 9 times faster, which makes it capable of helping make life-saving decisions in time