Modeling of Tumor Growth and Optimization of Therapeutic Protocol Design

Ph.DDOCTOR OF PHILOSOPH

Implementing decision tree-based algorithms in medical diagnostic decision support systems

As a branch of healthcare, medical diagnosis can be defined as finding the disease based on the signs and symptoms of the patient. To this end, the required information is gathered from different sources like physical examination, medical history and general information of the patient. Development of smart classification models for medical diagnosis is of great interest amongst the researchers. This is mainly owing to the fact that the machine learning and data mining algorithms are capable of detecting the hidden trends between features of a database. Hence, classifying the medical datasets using smart techniques paves the way to design more efficient medical diagnostic decision support systems. Several databases have been provided in the literature to investigate different aspects of diseases. As an alternative to the available diagnosis tools/methods, this research involves machine learning algorithms called Classification and Regression Tree (CART), Random Forest (RF) and Extremely Randomized Trees or Extra Trees (ET) for the development of classification models that can be implemented in computer-aided diagnosis systems. As a decision tree (DT), CART is fast to create, and it applies to both the quantitative and qualitative data. For classification problems, RF and ET employ a number of weak learners like CART to develop models for classification tasks. We employed Wisconsin Breast Cancer Database (WBCD), Z-Alizadeh Sani dataset for coronary artery disease (CAD) and the databanks gathered in Ghaem Hospital’s dermatology clinic for the response of patients having common and/or plantar warts to the cryotherapy and/or immunotherapy methods. To classify the breast cancer type based on the WBCD, the RF and ET methods were employed. It was found that the developed RF and ET models forecast the WBCD type with 100% accuracy in all cases. To choose the proper treatment approach for warts as well as the CAD diagnosis, the CART methodology was employed. The findings of the error analysis revealed that the proposed CART models for the applications of interest attain the highest precision and no literature model can rival it. The outcome of this study supports the idea that methods like CART, RF and ET not only improve the diagnosis precision, but also reduce the time and expense needed to reach a diagnosis. However, since these strategies are highly sensitive to the quality and quantity of the introduced data, more extensive databases with a greater number of independent parameters might be required for further practical implications of the developed models

Green Technologies for Production Processes

This book focuses on original research works about Green Technologies for Production Processes, including discrete production processes and process production processes, from various aspects that tackle product, process, and system issues in production. The aim is to report the state-of-the-art on relevant research topics and highlight the barriers, challenges, and opportunities we are facing. This book includes 22 research papers and involves energy-saving and waste reduction in production processes, design and manufacturing of green products, low carbon manufacturing and remanufacturing, management and policy for sustainable production, technologies of mitigating CO2 emissions, and other green technologies

Data procesing methodologies in the area of e-Health for categorizing therapeutic responses in patients with migraine

Tesis de la Universidad Complutense de Madrid, Facultad de Informática, leída el 19/11/2020La presente tesis doctoral estudia algunas metodologías de procesamiento de datos en el área de e-Health para clasificar las respuestas terapéuticas en pacientes con migraña. En un escenario real de e-Health, este trabajo se centra en la predicción de la respuesta al tratamiento de la migraña mediante el uso de registros médicos retrospectivos recopilados del hospital Clínico Universitario en Valladolid y del Hospital Universitario de La Princesa, en Madrid. el objetivo de este trabajo de investigación es plantear y responder las siguientes preguntas: ¿es posible predecir la respuesta a cada etapa del tratamiento para la migraña con BoNT-A? ¿existe un modelo predictivo para el tratamiento con BoNT-A en la migraña? ¿cómo responden estos modelos bajo registros incompletos? ¿es posible conocer aquellos factores médicos que hacen posible una alta respuesta al tratamiento con BoNT-A? ¿Los factores médicos utilizados para predecir la respuesta del tratamiento son coherentes con el conocimiento de los expertos médicos? Para responder a estas preguntas, este trabajo ha explorado e implementado diferentes enfoques para el entrenamiento de los modelos predictivos...This Ph.D. Thesis studies some data processing methodologies in the area of e-Health for categorizing therapeutic responses in patients with migraine. In a real e-Health scenario, this work focuses on the prediction of the response to the treatment of migraine through the use of retrospective medical records collected from Hospital Clínico Universitario in Valladolid and Hospital Universitario de La Princesa, in Madrid. The goal of this research work is to pose and answer the following questions: is it possible to predict the response to every stage of the BoNT-A treatment for migraine? Does a pre-treatment prediction model for the BoNT-A treatment in migraine exist? how do these models respond under missing values? Is it possible to reveal those medical factors that make it possible a high response to the BoNT-A treatment? Are the medical factors used to predict the response of the treatment coherent with the knowledge of medical experts? To answer these questions, this work has explored and implemented different approaches for the training of the predictive models...Fac. de InformáticaTRUEunpu

Biological Networks

Networks of coordinated interactions among biological entities govern a myriad of biological functions that span a wide range of both length and time scales—from ecosystems to individual cells and from years to milliseconds. For these networks, the concept “the whole is greater than the sum of its parts” applies as a norm rather than an exception. Meanwhile, continued advances in molecular biology and high-throughput technology have enabled a broad and systematic interrogation of whole-cell networks, allowing the investigation of biological processes and functions at unprecedented breadth and resolution—even down to the single-cell level. The explosion of biological data, especially molecular-level intracellular data, necessitates new paradigms for unraveling the complexity of biological networks and for understanding how biological functions emerge from such networks. These paradigms introduce new challenges related to the analysis of networks in which quantitative approaches such as machine learning and mathematical modeling play an indispensable role. The Special Issue on “Biological Networks” showcases advances in the development and application of in silico network modeling and analysis of biological systems

Using MapReduce Streaming for Distributed Life Simulation on the Cloud

Distributed software simulations are indispensable in the study of large-scale life models but often require the use of technically complex lower-level distributed computing frameworks, such as MPI. We propose to overcome the complexity challenge by applying the emerging MapReduce (MR) model to distributed life simulations and by running such simulations on the cloud. Technically, we design optimized MR streaming algorithms for discrete and continuous versions of Conway’s life according to a general MR streaming pattern. We chose life because it is simple enough as a testbed for MR’s applicability to a-life simulations and general enough to make our results applicable to various lattice-based a-life models. We implement and empirically evaluate our algorithms’ performance on Amazon’s Elastic MR cloud. Our experiments demonstrate that a single MR optimization technique called strip partitioning can reduce the execution time of continuous life simulations by 64%. To the best of our knowledge, we are the first to propose and evaluate MR streaming algorithms for lattice-based simulations. Our algorithms can serve as prototypes in the development of novel MR simulation algorithms for large-scale lattice-based a-life models.https://digitalcommons.chapman.edu/scs_books/1014/thumbnail.jp

Applications of Medical Physics

Applications of Medical Physics” is a Special Issue of Applied Sciences that has collected original research manuscripts describing cutting-edge physics developments in medicine and their translational applications. Reviews providing updates on the latest progresses in this field are also included. The collection includes a total of 20 contributions by authors from 9 different countries, which cover several areas of medical physics, spanning from radiation therapy, nuclear medicine, radiology, dosimetry, radiation protection, and radiobiology

A comparison of the CAR and DAGAR spatial random effects models with an application to diabetics rate estimation in Belgium

When hierarchically modelling an epidemiological phenomenon on a finite collection of sites in space, one must always take a latent spatial effect into account in order to capture the correlation structure that links the phenomenon to the territory. In this work, we compare two autoregressive spatial models that can be used for this purpose: the classical CAR model and the more recent DAGAR model. Differently from the former, the latter has a desirable property: its ρ parameter can be naturally interpreted as the average neighbor pair correlation and, in addition, this parameter can be directly estimated when the effect is modelled using a DAGAR rather than a CAR structure. As an application, we model the diabetics rate in Belgium in 2014 and show the adequacy of these models in predicting the response variable when no covariates are available

A Statistical Approach to the Alignment of fMRI Data

Multi-subject functional Magnetic Resonance Image studies are critical. The anatomical and functional structure varies across subjects, so the image alignment is necessary. We define a probabilistic model to describe functional alignment. Imposing a prior distribution, as the matrix Fisher Von Mises distribution, of the orthogonal transformation parameter, the anatomical information is embedded in the estimation of the parameters, i.e., penalizing the combination of spatially distant voxels. Real applications show an improvement in the classification and interpretability of the results compared to various functional alignment methods