Altered brain connectivity in sudden unexpected death in epilepsy (SUDEP) revealed using resting-state fMRI.

The circumstances surrounding SUDEP suggest autonomic or respiratory collapse, implying central failure of regulation or recovery. Characterisation of the communication among brain areas mediating such processes may shed light on mechanisms and noninvasively indicate risk. We used rs-fMRI to examine network properties among brain structures in people with epilepsy who suffered SUDEP (n = 8) over an 8-year follow-up period, compared with matched high- and low-risk subjects (n = 16/group) who did not suffer SUDEP during that period, and a group of healthy controls (n = 16). Network analysis was employed to explore connectivity within a 'regulatory-subnetwork' of brain regions involved in autonomic and respiratory regulation, and over the whole-brain. Modularity, the extent of network organization into separate modules, was significantly reduced in the regulatory-subnetwork, and the whole-brain, in SUDEP and high-risk. Increased participation, a local measure of inter-modular belonging, was evident in SUDEP and high-risk groups, particularly among thalamic structures. The medial prefrontal thalamus was increased in SUDEP compared with all other control groups, including high-risk. Patterns of hub topology were similar in SUDEP and high-risk, but were more extensive in low-risk patients, who displayed greater hub prevalence and a radical reorganization of hubs in the subnetwork. SUDEP is associated with reduced functional organization among cortical and sub-cortical brain regions mediating autonomic and respiratory regulation. Living high-risk subjects demonstrated similar patterns, suggesting such network measures may provide prospective risk-indicating value, though a crucial difference between SUDEP and high-risk was altered connectivity of the medial thalamus in SUDEP, which was also elevated compared with all sub-groups. Disturbed thalamic connectivity may reflect a potential non-invasive marker of elevated SUDEP risk

Unified Role Assignment Framework For Wireless Sensor Networks

Wireless sensor networks are made possible by the continuing improvements in embedded sensor, VLSI, and wireless radio technologies. Currently, one of the important challenges in sensor networks is the design of a systematic network management framework that allows localized and collaborative resource control uniformly across all application services such as sensing, monitoring, tracking, data aggregation, and routing. The research in wireless sensor networks is currently oriented toward a cross-layer network abstraction that supports appropriate fine or course grained resource controls for energy efficiency. In that regard, we have designed a unified role-based service paradigm for wireless sensor networks. We pursue this by first developing a Role-based Hierarchical Self-Organization (RBSHO) protocol that organizes a connected dominating set (CDS) of nodes called dominators. This is done by hierarchically selecting nodes that possess cumulatively high energy, connectivity, and sensing capabilities in their local neighborhood. The RBHSO protocol then assigns specific tasks such as sensing, coordination, and routing to appropriate dominators that end up playing a certain role in the network. Roles, though abstract and implicit, expose role-specific resource controls by way of role assignment and scheduling. Based on this concept, we have designed a Unified Role-Assignment Framework (URAF) to model application services as roles played by local in-network sensor nodes with sensor capabilities used as rules for role identification. The URAF abstracts domain specific role attributes by three models: the role energy model, the role execution time model, and the role service utility model. The framework then generalizes resource management for services by providing abstractions for controlling the composition of a service in terms of roles, its assignment, reassignment, and scheduling. To the best of our knowledge, a generic role-based framework that provides a simple and unified network management solution for wireless sensor networks has not been proposed previously

The Interaction of Intrinsic Dynamics and Network Topology in Determining Network Burst Synchrony

The pre-Bötzinger complex (pre-BötC), within the mammalian respiratory brainstem, represents an ideal system for investigating the synchronization properties of complex neuronal circuits via the interaction of cell-type heterogeneity and network connectivity. In isolation, individual respiratory neurons from the pre-BötC may be tonically active, rhythmically bursting, or quiescent. Despite this intrinsic heterogeneity, coupled networks of pre-BötC neurons en bloc engage in synchronized bursting that can drive inspiratory motor neuron activation. The region's connection topology has been recently characterized and features dense clusters of cells with occasional connections between clusters. We investigate how the dynamics of individual neurons (quiescent/bursting/tonic) and the betweenness centrality of neurons’ positions within the network connectivity graph interact to govern network burst synchrony, by simulating heterogeneous networks of computational model pre-BötC neurons. Furthermore, we compare the prevalence and synchrony of bursting across networks constructed with a variety of connection topologies, analyzing the same collection of heterogeneous neurons in small-world, scale-free, random, and regularly structured networks. We find that several measures of network burst synchronization are determined by interactions of network topology with the intrinsic dynamics of neurons at central network positions and by the strengths of synaptic connections between neurons. Surprisingly, despite the functional role of synchronized bursting within the pre-BötC, we find that synchronized network bursting is generally weakest when we use its specific connection topology, which leads to synchrony within clusters but poor coordination across clusters. Overall, our results highlight the relevance of interactions between topology and intrinsic dynamics in shaping the activity of networks and the concerted effects of connectivity patterns and dynamic heterogeneities

Mobile Ad Hoc Networks

Guiding readers through the basics of these rapidly emerging networks to more advanced concepts and future expectations, Mobile Ad hoc Networks: Current Status and Future Trends identifies and examines the most pressing research issues in Mobile Ad hoc Networks (MANETs). Containing the contributions of leading researchers, industry professionals, and academics, this forward-looking reference provides an authoritative perspective of the state of the art in MANETs. The book includes surveys of recent publications that investigate key areas of interest such as limited resources and the mobility of mobile nodes. It considers routing, multicast, energy, security, channel assignment, and ensuring quality of service. Also suitable as a text for graduate students, the book is organized into three sections: Fundamentals of MANET Modeling and Simulation—Describes how MANETs operate and perform through simulations and models Communication Protocols of MANETs—Presents cutting-edge research on key issues, including MAC layer issues and routing in high mobility Future Networks Inspired By MANETs—Tackles open research issues and emerging trends Illustrating the role MANETs are likely to play in future networks, this book supplies the foundation and insight you will need to make your own contributions to the field. It includes coverage of routing protocols, modeling and simulations tools, intelligent optimization techniques to multicriteria routing, security issues in FHAMIPv6, connecting moving smart objects to the Internet, underwater sensor networks, wireless mesh network architecture and protocols, adaptive routing provision using Bayesian inference, and adaptive flow control in transport layer using genetic algorithms

Cortical Functional architectures as contact and sub-Riemannian geometry

In a joint paper, Jean Petitot together with the authors of the present paper described the functional geometry of the visual cortex as the symplectization of a contact form to describe the family of cells sensitive to position, orientation and scale. In the present paper, as a "homage" to the enormous contribution of Jean Petitot to neurogeometry, we will extend this approach to more complex functional architectures built as a sequence of contactization or a symplectization process, able to extend the dimension of the space. We will also outline a few examples where a sub-Riemannian lifting is needed

A Tutorial on Clique Problems in Communications and Signal Processing

Since its first use by Euler on the problem of the seven bridges of K\"onigsberg, graph theory has shown excellent abilities in solving and unveiling the properties of multiple discrete optimization problems. The study of the structure of some integer programs reveals equivalence with graph theory problems making a large body of the literature readily available for solving and characterizing the complexity of these problems. This tutorial presents a framework for utilizing a particular graph theory problem, known as the clique problem, for solving communications and signal processing problems. In particular, the paper aims to illustrate the structural properties of integer programs that can be formulated as clique problems through multiple examples in communications and signal processing. To that end, the first part of the tutorial provides various optimal and heuristic solutions for the maximum clique, maximum weight clique, and $k$-clique problems. The tutorial, further, illustrates the use of the clique formulation through numerous contemporary examples in communications and signal processing, mainly in maximum access for non-orthogonal multiple access networks, throughput maximization using index and instantly decodable network coding, collision-free radio frequency identification networks, and resource allocation in cloud-radio access networks. Finally, the tutorial sheds light on the recent advances of such applications, and provides technical insights on ways of dealing with mixed discrete-continuous optimization problems

Mobile Ad Hoc Networks

Guiding readers through the basics of these rapidly emerging networks to more advanced concepts and future expectations, Mobile Ad hoc Networks: Current Status and Future Trends identifies and examines the most pressing research issues in Mobile Ad hoc Networks (MANETs). Containing the contributions of leading researchers, industry professionals, and academics, this forward-looking reference provides an authoritative perspective of the state of the art in MANETs. The book includes surveys of recent publications that investigate key areas of interest such as limited resources and the mobility of mobile nodes. It considers routing, multicast, energy, security, channel assignment, and ensuring quality of service. Also suitable as a text for graduate students, the book is organized into three sections: Fundamentals of MANET Modeling and Simulation—Describes how MANETs operate and perform through simulations and models Communication Protocols of MANETs—Presents cutting-edge research on key issues, including MAC layer issues and routing in high mobility Future Networks Inspired By MANETs—Tackles open research issues and emerging trends Illustrating the role MANETs are likely to play in future networks, this book supplies the foundation and insight you will need to make your own contributions to the field. It includes coverage of routing protocols, modeling and simulations tools, intelligent optimization techniques to multicriteria routing, security issues in FHAMIPv6, connecting moving smart objects to the Internet, underwater sensor networks, wireless mesh network architecture and protocols, adaptive routing provision using Bayesian inference, and adaptive flow control in transport layer using genetic algorithms