Analyzing genome-wide association studies with an FDR controlling modification of the Bayesian information criterion

The prevailing method of analyzing GWAS data is still to test each marker individually, although from a statistical point of view it is quite obvious that in case of complex traits such single marker tests are not ideal. Recently several model selection approaches for GWAS have been suggested, most of them based on LASSO-type procedures. Here we will discuss an alternative model selection approach which is based on a modification of the Bayesian Information Criterion (mBIC2) which was previously shown to have certain asymptotic optimality properties in terms of minimizing the misclassification error. Heuristic search strategies are introduced which attempt to find the model which minimizes mBIC2, and which are efficient enough to allow the analysis of GWAS data. Our approach is implemented in a software package called MOSGWA. Its performance in case control GWAS is compared with the two algorithms HLASSO and GWASelect, as well as with single marker tests, where we performed a simulation study based on real SNP data from the POPRES sample. Our results show that MOSGWA performs slightly better than HLASSO, whereas according to our simulations GWASelect does not control the type I error when used to automatically determine the number of important SNPs. We also reanalyze the GWAS data from the Wellcome Trust Case-Control Consortium (WTCCC) and compare the findings of the different procedures

RBATMWSN: Recursive Bayesian approach to trust management in wireless sensor networks

This paper introduces a new trust model and a reputation system for wireless sensor networks based on a sensed continuous data. It establishes the continuous version of the beta reputation system introduced in [1] and applied to binary events and presents a new Gaussian Reputation System for Sensor Networks (GRSSN) . We introduce a theoretically sound Bayesian probabilistic approach for mixing second-hand information from neighbouring nodes with directly observed information. ©2007 IEEE

A Developmental Model of Trust in Humanoid Robots

Trust between humans and artificial systems has recently received increased attention due to the widespread use of autonomous systems in our society. In this context trust plays a dual role. On the one hand it is necessary to build robots that are perceived as trustworthy by humans. On the other hand we need to give to those robots the ability to discriminate between reliable and unreliable informants. This thesis focused on the second problem, presenting an interdisciplinary investigation of trust, in particular a computational model based on neuroscientific and psychological assumptions. First of all, the use of Bayesian networks for modelling causal relationships was investigated. This approach follows the well known theory-theory framework of the Theory of Mind (ToM) and an established line of research based on the Bayesian description of mental processes. Next, the role of gaze in human-robot interaction has been investigated. The results of this research were used to design a head pose estimation system based on Convolutional Neural Networks. The system can be used in robotic platforms to facilitate joint attention tasks and enhance trust. Finally, everything was integrated into a structured cognitive architecture. The architecture is based on an actor-critic reinforcement learning framework and an intrinsic motivation feedback given by a Bayesian network. In order to evaluate the model, the architecture was embodied in the iCub humanoid robot and used to replicate a developmental experiment. The model provides a plausible description of children's reasoning that sheds some light on the underlying mechanism involved in trust-based learning. In the last part of the thesis the contribution of human-robot interaction research is discussed, with the aim of understanding the factors that influence the establishment of trust during joint tasks. Overall, this thesis provides a computational model of trust that takes into account the development of cognitive abilities in children, with a particular emphasis on the ToM and the underlying neural dynamics.THRIVE, Air Force Office of Scientific Research, Award No. FA9550-15-1-002