The Ursinus Weekly, May 9, 1927

Ursinus defeated by strong Muhlenberg team Saturday, 14-6 • Y.W.C.A. cabinet held party at Camp Arcola • Cornerstones of new dormitories were laid on Wednesday morning • Ursinus host of Montgomery County school exhibition • Tennis team wins over Osteopathy; but loses contest to Moravian • Conference planned by YMCA to take place at Green Lane camp • Rain halts Swarthmore game; will play today • Preparations for May Day fete being completed • Junior class play nearing completion • Debating teams banqueted on Thursday evening • Six new members elected to Tau Kappa Alpha • The New Earth oratorio • Sophs elect councilmen • Future baseball gameshttps://digitalcommons.ursinus.edu/weekly/2248/thumbnail.jp

National cross-sectional survey of 1.14 million NHS staff SARS-CoV-2 serology tests: a comparison of NHS staff with regional community seroconversion rates

OBJECTIVES: An initial report of findings from 1.14 million SARS CoV-2 serology tests in National Health Service (NHS) staff to compare NHS staff seroconversion with community seroconversion rates at a regional level. DESIGN: A national cross-sectional survey. SETTING: A SARS-CoV-2 antibody testing programme offered across all NHS Trusts. PARTICIPANTS: 1.14 million NHS staff. INTERVENTION: SARS-CoV-2 antibody testing. PRIMARY AND SECONDARY OUTCOME MEASURES: SARS-CoV-2 antibody testing was used to estimate the seroprevalence of SARS-CoV-2 in NHS staff by region, compared with community seroprevalence as determined by the COVID-19 Infection Survey (Office for National Statistics). We also explored seroprevalence trends by regional COVID-19 activity, using regional death rates as a proxy for COVID-19 'activity'. RESULTS: 1 146 310 tests were undertaken on NHS staff between 26 May and 31 August 2020. 186 897 NHS tests were positive giving a seroconversion rate of 16.3% (95% CI 16.2% to 16.4%), in contrast to the national community seroconversion rate of 5.9% (95% CI 5.3% to 6.6%). There was significant geographical regional variation, which mirrored the trends seen in community prevalence rates. NHS staff were infected at a higher rate than the general population (OR 3.1, 95% CI 2.8 to 3.5). NHS seroconversion by regional death rate suggested a trend towards higher seroconversion rates in the areas with higher COVID-19 'activity'. CONCLUSIONS: This is the first cross-sectional survey assessing the risk of COVID-19 disease in healthcare workers at a national level. It is the largest study of its kind. It suggests that NHS staff have a significantly higher rate of COVID-19 seroconversion compared with the general population in England, with regional variation across the country which matches the background population prevalence trends. There was also a trend towards higher seroconversion rates in areas which had experienced high COVID-19 clinical activity. This work has global significance in terms of the value of such a testing programme and contributing to the understanding of healthcare worker seroconversion at a national level

Bulloch Times

https://digitalcommons.georgiasouthern.edu/bulloch-news-issues/1176/thumbnail.jp

Bacillus Wiedmannii biovar thuringiensis: A specialized mosquitocidal pathogen with plasmids from diverse origins

Bacillus cereus sensu lato also known as B. Cereus group is composed of an ecologically diverse bacterial group with an increasing number of related species, some of which are medically or agriculturally important. Numerous efforts have been undertaken to allowpresumptive differentiation of B. Cereus group species from one another. FCC41 is a Bacillus sp. Strain toxic against mosquito species like Aedes aegypti, Aedes (Ochlerotatus) albifasciatus, Culex pipiens, Culex quinquefasciatus, and Culex apicinus, some of them responsible for the transmission of vector-borne diseases. Here, we report the complete genome sequence of FCC41 strain, which consists of one circular chromosome and eight circular plasmids ranging in size from 8 to 490 kb. This strain harbors six crystal protein genes, including cry24Ca, twocry4-like and two cry52-like, a cry41-like parasporin gene and multiple virulence factors. The phylogenetic analysis of the whole-genome sequence of this strain with molecular approaches places this strain into the Bacillus wiedmannii cluster. However, according with phenotypical characteristics such as the mosquitocidal activity due to the presence of Cry proteins found in the parasporal body and cry genes encoded in plasmids of different sizes, indicate that this strain could be renamed as B. Wiedmannii biovar thuringiensis strain FCC41.Fil: Lazarte, Jorge Nicolás. Fundación para Investigaciones Biológicas Aplicadas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Biodiversidad y Biotecnología; ArgentinaFil: Lopez, Rocio de la Paz. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Biodiversidad y Biotecnología; Argentina. Fundación para Investigaciones Biológicas Aplicadas; ArgentinaFil: Ghiringhelli, Pablo Daniel. Universidad Nacional de Quilmes; ArgentinaFil: Berón, Corina Marta. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Biodiversidad y Biotecnología; Argentina. Fundación para Investigaciones Biológicas Aplicadas; Argentin

Music in George Eliot\u27s Life and Works

In the following thesis the author has attempted to show the importance of music to George Eliot personally, and her response to it as portrayed by the various characters in her books. In this study it was necessary to point out the various phases of music with which George Eliot was familiar and the interesting way in which she incorporated them in her stories

The Ithacan, 1938-01-07

https://digitalcommons.ithaca.edu/ithacan_1937-38/1006/thumbnail.jp

The mechanisms of Chansu in inducing efficient apoptosis in colon cancer cells

Chansu is one of the most widely used traditional Chinese medicines in China, Japan, and other Southeast Asian countries primarily for antipain, anti-inflammation, and recently anticancer. Over 10 recipes and remedies contained Chansu, which are easily available in pharmacies and hospitals, but the mechanisms of action were not clearly articulated. In the present study, Cinobufagin (CBF), the major compound of Chansu, was employed as a surrogate marker to determine its ability in inducing cancer cell death. As expected, CBF has significant cancer-killing capacity for a range of cancers, but such ability differs markedly. Colon and prostate cancers are more sensitive than skin and lung cancers. Interestingly, cancer cells die through apoptotic pathway either being biphasic caspase- 3-dependent (HCT116) or independent (HT29). Multipathway analysis reveals that CBF-induced apoptosis is likely modulated by the hypoxia-inducing factor-1 alpha subunit (HIF-