Histopathological image analysis : a review

Over the past decade, dramatic increases in computational power and improvement in image analysis algorithms have allowed the development of powerful computer-assisted analytical approaches to radiological data. With the recent advent of whole slide digital scanners, tissue histopathology slides can now be digitized and stored in digital image form. Consequently, digitized tissue histopathology has now become amenable to the application of computerized image analysis and machine learning techniques. Analogous to the role of computer-assisted diagnosis (CAD) algorithms in medical imaging to complement the opinion of a radiologist, CAD algorithms have begun to be developed for disease detection, diagnosis, and prognosis prediction to complement the opinion of the pathologist. In this paper, we review the recent state of the art CAD technology for digitized histopathology. This paper also briefly describes the development and application of novel image analysis technology for a few specific histopathology related problems being pursued in the United States and Europe

Extreme Entropy Machines: Robust information theoretic classification

Most of the existing classification methods are aimed at minimization of empirical risk (through some simple point-based error measured with loss function) with added regularization. We propose to approach this problem in a more information theoretic way by investigating applicability of entropy measures as a classification model objective function. We focus on quadratic Renyi's entropy and connected Cauchy-Schwarz Divergence which leads to the construction of Extreme Entropy Machines (EEM). The main contribution of this paper is proposing a model based on the information theoretic concepts which on the one hand shows new, entropic perspective on known linear classifiers and on the other leads to a construction of very robust method competetitive with the state of the art non-information theoretic ones (including Support Vector Machines and Extreme Learning Machines). Evaluation on numerous problems spanning from small, simple ones from UCI repository to the large (hundreads of thousands of samples) extremely unbalanced (up to 100:1 classes' ratios) datasets shows wide applicability of the EEM in real life problems and that it scales well

Multi-Classifiers And Decision Fusion For Robust Statistical Pattern Recognition With Applications To Hyperspectral Classification

In this dissertation, a multi-classifier, decision fusion framework is proposed for robust classification of high dimensional data in small-sample-size conditions. Such datasets present two key challenges. (1) The high dimensional feature spaces compromise the classifiers’ generalization ability in that the classifier tends to overit decision boundaries to the training data. This phenomenon is commonly known as the Hughes phenomenon in the pattern classification community. (2) The small-sample-size of the training data results in ill-conditioned estimates of its statistics. Most classifiers rely on accurate estimation of these statistics for modeling training data and labeling test data, and hence ill-conditioned statistical estimates result in poorer classification performance. This dissertation tests the efficacy of the proposed algorithms to classify primarily remotely sensed hyperspectral data and secondarily diagnostic digital mammograms, since these applications naturally result in very high dimensional feature spaces and often do not have sufficiently large training datasets to support the dimensionality of the feature space. Conventional approaches, such as Stepwise LDA (S-LDA) are sub-optimal, in that they utilize a small subset of the rich spectral information provided by hyperspectral data for classification. In contrast, the approach proposed in this dissertation utilizes the entire high dimensional feature space for classification by identifying a suitable partition of this space, employing a bank-of-classifiers to perform “local” classification over this partition, and then merging these local decisions using an appropriate decision fusion mechanism. Adaptive classifier weight assignment and nonlinear pre-processing (in kernel induced spaces) are also proposed within this framework to improve its robustness over a wide range of fidelity conditions. Experimental results demonstrate that the proposed framework results in significant improvements in classification accuracies (as high as a 12% increase) over conventional approaches

Domain Generalization for Medical Image Analysis: A Survey

Medical Image Analysis (MedIA) has become an essential tool in medicine and healthcare, aiding in disease diagnosis, prognosis, and treatment planning, and recent successes in deep learning (DL) have made significant contributions to its advances. However, DL models for MedIA remain challenging to deploy in real-world situations, failing for generalization under the distributional gap between training and testing samples, known as a distribution shift problem. Researchers have dedicated their efforts to developing various DL methods to adapt and perform robustly on unknown and out-of-distribution data distributions. This paper comprehensively reviews domain generalization studies specifically tailored for MedIA. We provide a holistic view of how domain generalization techniques interact within the broader MedIA system, going beyond methodologies to consider the operational implications on the entire MedIA workflow. Specifically, we categorize domain generalization methods into data-level, feature-level, model-level, and analysis-level methods. We show how those methods can be used in various stages of the MedIA workflow with DL equipped from data acquisition to model prediction and analysis. Furthermore, we include benchmark datasets and applications used to evaluate these approaches and analyze the strengths and weaknesses of various methods, unveiling future research opportunities

Multi-Classifiers And Decision Fusion For Robust Statistical Pattern Recognition With Applications To Hyperspectral Classification

In this dissertation, a multi-classifier, decision fusion framework is proposed for robust classification of high dimensional data in small-sample-size conditions. Such datasets present two key challenges. (1) The high dimensional feature spaces compromise the classifiers’ generalization ability in that the classifier tends to overit decision boundaries to the training data. This phenomenon is commonly known as the Hughes phenomenon in the pattern classification community. (2) The small-sample-size of the training data results in ill-conditioned estimates of its statistics. Most classifiers rely on accurate estimation of these statistics for modeling training data and labeling test data, and hence ill-conditioned statistical estimates result in poorer classification performance. This dissertation tests the efficacy of the proposed algorithms to classify primarily remotely sensed hyperspectral data and secondarily diagnostic digital mammograms, since these applications naturally result in very high dimensional feature spaces and often do not have sufficiently large training datasets to support the dimensionality of the feature space. Conventional approaches, such as Stepwise LDA (S-LDA) are sub-optimal, in that they utilize a small subset of the rich spectral information provided by hyperspectral data for classification. In contrast, the approach proposed in this dissertation utilizes the entire high dimensional feature space for classification by identifying a suitable partition of this space, employing a bank-of-classifiers to perform “local” classification over this partition, and then merging these local decisions using an appropriate decision fusion mechanism. Adaptive classifier weight assignment and nonlinear pre-processing (in kernel induced spaces) are also proposed within this framework to improve its robustness over a wide range of fidelity conditions. Experimental results demonstrate that the proposed framework results in significant improvements in classification accuracies (as high as a 12% increase) over conventional approaches

Classification of breast tissue in mammograms using efficient coding

<p>Abstract</p> <p>Background</p> <p>Female breast cancer is the major cause of death by cancer in western countries. Efforts in Computer Vision have been made in order to improve the diagnostic accuracy by radiologists. Some methods of lesion diagnosis in mammogram images were developed based in the technique of principal component analysis which has been used in efficient coding of signals and 2D Gabor wavelets used for computer vision applications and modeling biological vision.</p> <p>Methods</p> <p>In this work, we present a methodology that uses efficient coding along with linear discriminant analysis to distinguish between mass and non-mass from 5090 region of interest from mammograms.</p> <p>Results</p> <p>The results show that the best rates of success reached with Gabor wavelets and principal component analysis were 85.28% and 87.28%, respectively. In comparison, the model of efficient coding presented here reached up to 90.07%.</p> <p>Conclusions</p> <p>Altogether, the results presented demonstrate that independent component analysis performed successfully the efficient coding in order to discriminate mass from non-mass tissues. In addition, we have observed that LDA with ICA bases showed high predictive performance for some datasets and thus provide significant support for a more detailed clinical investigation.</p

Spatially varying threshold models for the automated segmentation of radiodense tissue in digitized mammograms

The percentage of radiodense (bright) tissue in a mammogram has been correlated to an increased risk of breast cancer. This thesis presents an automated method to quantify the amount of radiodense tissue found in a digitized mammogram. The algorithm employs a radial basis function neural network in order to segment the breast tissue region from the remainder of the X-ray. A spatially varying Neyman-Pearson threshold is used to calculate the percentage of radiodense tissue and compensate for the effects of tissue compression that occurs during a mammography procedure. Results demonstrating the efficacy of the technique are demonstrated by exercising the algorithm on two separate sets of mammograms - one obtained from Brigham Women\u27s Hospital, Harvard Medical School and the other set obtained from Fox Chase Cancer Center and digitized at Rowan University. The results of the algorithm compare favorably with a previously established manual segmentation technique

Advances in Cost-Effectiveness Analysis of Health Interventions

The growing application of cost-effectiveness (CE) analysis and controversies about its methods has led to a need to explore its welfare economic foundations. Examination of its welfare theoretic foundations can provide a rationale for selecting specific standards for the application of CE analysis while deepening our understanding of the implications of alternative methodological approaches. In this paper, I explore conditions under which decision making based on CE analysis, carried out a specific way, leads to a distribution of resources that has desirable social welfare properties. The first section describes the basics of CE analysis and how it can be applied to aid decisions about the allocation of health resources. The paper then turns to the potential welfare economic foundations of CE analysis, and addresses specific issues in carrying out CE analysis, such as which costs to include, whose perspective matters in the analysis, and how health outcomes are measured. It demonstrates how a welfare economic foundation can help resolve ambiguities and uncertainties about the application of CE analysis. The paper also discusses the limitations of such an approach, which indeed reflect limitations of CE analysis as an analytic framework. Finally, it addresses unresolved issues such as the difficulties in using the results of CE analysis to make health policy at the societal or group level.