11,778 research outputs found
Comparison of physical fitness between healthy and mildâtoâmoderate asthmatic children with exercise symptoms: A crossâsectional study
.Objective
Asthma is a chronic disease that may affect physical fitness, although its primary effects on exercise capacity, muscle strength, functionality and lifestyle, in children and adolescents, are still poorly understood. This study aimed to evaluate the differences in cardiorespiratory fitness, muscle strength, lifestyle, lung function, and functionality between asthmatics with exercise symptoms and healthy children. In addition, we have analyzed the association between clinical history and the presence of asthma.
Study Design
Cross-sectional study including 71 patients with a diagnosis of asthma and 71 healthy children and adolescents (7â17 years of age). Anthropometric data, clinical history, disease control, lifestyle (KIDMED and physical activity questionnaires), lung function (spirometry), exercise-induced bronchoconstriction test, aerobic fitness (cardiopulmonary exercise test), muscle strength and functionality (timed up and go; timed up and down stairs) were evaluated.
Results
Seventy-one patients with asthma (mean age 11.5â±â2.7) and 71 healthy subjects (mean age 10.7â±â2.5) were included. All asthmatic children had mild to moderate and stable asthma. EIB occurred in 56.3% of asthmatic children. Lung function was significantly (pâ<â.05) lower in the asthmatic group when compared to healthy peers, as well as the cardiorespiratory fitness, muscle strength, lifestyle and functionality. Moreover, asthmatic children were more likely to have atopic dermatitis, allergic reactions, food allergies, and a family history of asthma when compared to healthy children.
Conclusions
Children with mild-to-moderate asthma presenting exercise symptoms show a reduction in cardiorespiratory fitness, muscle strength, lung function, functionality, and lifestyle when compared to healthy peers. The study provides data for pediatricians to support exercise practice aiming to improve prognosis and quality of life in asthmatic children.S
Factors Influencing Teachers' Use of ICT in Class: Evidence from a Multilevel Logistic Model
Information and Communication Technologies (ICTs) have become a key factor in the educational context, especially in the aftermath of the COVID-19 pandemic, and, correctly implemented, can help to improve academic performance. The aim of this research was to analyse the factors that influence teachers' decisions to use ICT more- or less frequently to carry out tasks and exercises in their classes. To this end, we estimated a multilevel logistic model with census data from the individualized evaluation of students of the Community of Madrid (Spain) carried out at the end of the 2018-2019 academic year in primary and secondary education. Additionally, we applied multiple imputation techniques to deal with missing values. Based on our results, we found that motivated teachers who have received ICT training, teach calm and respectful classes, and work at schools where students have access to digital devices and frequently use ICT at home, have a high predisposition to use ICT in their classes. Considering our results, our recommendations are aimed at improving teacher training in ICT, encouraging a frequent but responsible use of ICT at home, and increasing the provision of technological resources in schools
Making Sense of Ayahuasca Non-Sense: A critical study of UK groups consuming a psychoactive plant mixture and their struggle to find religious meaning
How we make sense of ourselves, and the cosmos is an ongoing concern, guided by the people we meet, environments we exist within, and plants we consume. Having spent over a year observing forty-nine participants within three UK-based ayahuasca churches, it is clear that the psychoactive 'brew' ayahuasca creates intense changes to how individuals think about themselves and the world they live in. At the heart of the ayahuasca experience are non-sensical hallucinations and visions, which often exist outside of perceptual understanding, leaving individuals feeling lost in an unknowable universe. As we will come to see, making sense of non-sensical ayahuasca experiences requires individuals to negotiate multiple 'common-sense' views of reality. Taking a view that mind is something that happens within life, this ethnographic study uses participant observation, interviews, conversations, personal diaries, and my experiences as an ayahuasca tourist to detail how making sense of reality is also an act of making oneself. In so doing, I argue that ayahuasca hallucinations and visions function as a source of ongoing mental innovation, facilitating preferred views of reality throughout these psychoactive churches. Critically, we will see how frequent ayahuasca consumption engenders in-depth beliefs in the supernatural, and in particular, devotion to the goddess Ayahuasca, who functions as the unchallengeable road to knowing oneself and reality. Acting as an otherworldly guide, the immaterial goddess Ayahuasca plays a key part in how individuals convert non-sensical experiences into sense, while providing practical advice for how to achieve salvation. Problematically though, positioning the universe and oneself as predominantly supernatural tends to erode beliefs in the physical world, leaving these churches with incoherent views of reality, and at the periphery of everyday social life. As such, church doctrines seem increasingly unable to cope with life outside of their groups, and thus, tactically stigmatise competing views of reality as sinful and individuals espousing such heresies as under the control of malevolent demonic beings. Not surprisingly, this binary belief in a good and evil cosmos is a powerful regulatory force dictating what reality is within these churches, and who church members can claim to be
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Choosers: A Visual Programming Language for Nondeterministic Music Composition by Non-Programmers
This thesis focuses on the design of Choosers, a prototype algorithmic programming system centred around a new abstraction (of the same name) designed to allow non-programmers access to nondeterministic music composition methods.
Algorithmic composition typically involves structural elements such as indeterminism, parallelism, choice, multi-choice, nesting, weighting, and looping. There are powerful existing tools for manipulating these and other elements of music. However, while these systems give substantial compositional power to musicians who are also skilled programmers, many musicians who lack programming skills find these tools inaccessible and difficult to understand and use. This thesis presents the design and evaluation of a prototype visual programming language designed to allow structural elements of the kind involved in nondeterministic music composition to be readily visualised and manipulated, while making little or no demand on programming ability.
Initially, a Cognitive Dimensions of Notations review of a representative selection of user interfaces for algorithmic composition software was conducted. The review led to a set of findings used to identify candidate design principles which were then tested via a series of design exercises. The findings from these design exercises led to the development of a new abstraction, the Chooser, via a series of iterative design cycles. Once a candidate design had been finalised it was evaluated with participants via two sets of programming walkthroughs, with the findings from each step used to refine the formalism. The final study used Choosers as a design probe through a series of interviews with domain experts in which manipulable compositions were introduced to prompt discussions on potential future implications for music computing education, music production, and music composition
Donât be a Waster! Student Perceptions of Recycling Strategies at an English Universityâs Halls of Residence
Purpose: This paper explores student perceptions of recycling, and explores whether one universityâs strategy helped or hindered student recycling in their university's halls of residence. There is near-universal acknowledgement of the urgency of the climate crisis, yet household recycling rates remain low at 45.2%. Student-recycling rates have been suggested to be even lower. After a brief consideration of the recent history of sustainability and recycling, this paper identifies the actions required to increase student recycling, including peer influence, education and information, physical structures, and attitudes and motivations. Design/methodology/approach: Twelve in-depth, semi-structured interviews were undertaken at one Southern English university. The rich, qualitative data obtained were then analysed thematically. The theory of environmentally significant behaviour provided a framework for understanding perceptions and behaviours in that site. Findings: Confirming aspects of existing literature, studentsâ recycling behaviours were found to be limited through lack of perceived ability, lack of facilities and unconfident knowledge. Students were also found to be limiting their own actions. A holistic approach including peer influence, education and information, physical structures, and attitudes and motivations was recommended. Originality: There is little research into student recycling behaviours and limited literature concerning halls of residence, especially in the UK. This paper draws on one case to add to nascent understandings. Whilst limited to one site and by sample size, a number of recommendations are made, covering university facilities, student empowerment, and individual responsibility to increase future recycling
Mandatory detention and treatment of drug users in Malaysia : The implications for the principles of human rights
The research framework is founded upon a critical analysis of the extent to which the legal process involved in the mandatory treatment and rehabilitation of drug users in Malaysia is consistent with the principles of human rights according to the national and international human rights instruments; the Malaysian Constitution and the UDHR respectively. The mandatory treatment is based upon the principles of punishment rather than rehabilitation. The arrest and detention of these drug users, which are salient features of the legal process raises the issue of serious violations of the human rights principles. To fulfill the true objective of the government's Drug Intervention Programme (DIP) through treatment and rehabilitation at Puspen centres, by reducing drug dependency and preventing relapse, treatment must be consistent with the principles of human rights for it to be effective. Data and information were gathered from empirical research through the application of various qualitative methods: these include a case study, direct observation, semistructured and unstructured interviews with key stakeholders, focus group with former drug users and an analysis of case files. Findings revealed that the legal process of funneling 'suspected drug dependants' into treatment involved a series of breaches of the fundamental human rights principles that could not be justified. The scope of police powers with regard to the arrest and detention of 'suspected drug dependants' has been widely abused and such exercise of power has been without proper statutory safeguards to protect the rights of these individuals from such arbitrary arrest. Unnecessary prolonged period of detention have led to grave infringement of individual liberty whilst conditions of confinement and failure to provide medical assistance and medication-assisted treatment particularly during withdrawal symptoms have amounted to inhuman, cruel and degrading treatment. Lack of due process including denying the right to legal representation has caused severe legal implications upon the drug users. As a consequence, the flaw in the legal system has deprived them of their constitutional rights and in contravention of
the international human rights principles. Recommendations are proposed for an immediate reform to the drug policies and procedures with paramount consideration towards a more humane and effective treatment
Modelling approaches for histology-independent cancer drugs to inform NICE appraisals : a systematic review and decision-framework
Background
The first histology-independent marketing authorisation in Europe was granted in 2019. This was the first time that a cancer treatment was approved based on a common biomarker rather than the location in the body at which the tumour originated. This research aims to explore the implications for National Institute for Health and Care Excellence appraisals.
Methods
Targeted reviews were undertaken to determine the type of evidence that is likely to be available at the point of marketing authorisation and the analyses required to support National Institute for Health and Care Excellence appraisals. Several challenges were identified concerning the design and conduct of trials for histology-independent products, the greater levels of heterogeneity within the licensed population and the use of surrogate end points. We identified approaches to address these challenges by reviewing key statistical literature that focuses on the design and analysis of histology-independent trials and by undertaking a systematic review to evaluate the use of response end points as surrogate outcomes for survival end points. We developed a decision framework to help to inform approval and research policies for histology-independent products. The framework explored the uncertainties and risks associated with different approval policies, including the role of further data collection, pricing schemes and stratified decision-making.
Results
We found that the potential for heterogeneity in treatment effects, across tumour types or other characteristics, is likely to be a central issue for National Institute for Health and Care Excellence appraisals. Bayesian hierarchical methods may serve as a useful vehicle to assess the level of heterogeneity across tumours and to estimate the pooled treatment effects for each tumour, which can inform whether or not the assumption of homogeneity is reasonable. Our review suggests that response end points may not be reliable surrogates for survival end points. However, a surrogate-based modelling approach, which captures all relevant uncertainty, may be preferable to the use of immature survival data. Several additional sources of heterogeneity were identified as presenting potential challenges to National Institute for Health and Care Excellence appraisal, including the cost of testing, baseline risk, quality of life and routine management costs. We concluded that a range of alternative approaches will be required to address different sources of heterogeneity to support National Institute for Health and Care Excellence appraisals. An exemplar case study was developed to illustrate the nature of the assessments that may be required.
Conclusions
Adequately designed and analysed basket studies that assess the homogeneity of outcomes and allow borrowing of information across baskets, where appropriate, are recommended. Where there is evidence of heterogeneity in treatment effects and estimates of cost-effectiveness, consideration should be given to optimised recommendations. Routine presentation of the scale of the consequences of heterogeneity and decision uncertainty may provide an important additional approach to the assessments specified in the current National Institute for Health and Care Excellence methods guide.
Further research
Further exploration of Bayesian hierarchical methods could help to inform decision-makers on whether or not there is sufficient evidence of homogeneity to support pooled analyses. Further research is also required to determine the appropriate basis for apportioning genomic testing costs where there are multiple targets and to address the challenges of uncontrolled Phase II studies, including the role and use of surrogate end points
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Engaging Distance Learners in an Academic Community: Student Hub Live
In higher education (HE), studies of effective practice relating to student retention, progression and attainment suggest that student engagement is a major factor in terms of success, and this involves a sense of belonging to a community. Studies have identified initiatives that have proved successful in traditional HE contexts, however ideas of belonging and community are problematic when translated to distance-learning contexts. Many distance-learning students, who are often mature and part-time learners, appear to be successful in their studies without identifying as a student or interacting socially with others, which calls into question the way in which belonging is conceptualised in distance-learning settings. The focus of this research was to identify the value of attending specific, live, online, interactive events at Student Hub Live (SHL) which were designed by the Open University to facilitate academic community and to provide a space outside of the curriculum for students to socialise and perform other aspects of student identity that require interaction with others. Using an ethnographic approach and grounded theory methods, chatlogs of four SHL events were analysed and the emergent themes informed semi-structured interviews which were carried out with six participants, all of whom had attended SHL events. Both sets of findings were combined and further analysed using thematic network maps. The finding was that communities of practice with shared repertoires enabled students to feel a sense of belonging through participating in discussions which created a conducive learning environment to develop skills, share experiences and feel validated. Community and belonging enabled students to deeply apply learning to their studies through sharing the experience and their experiences with others. In this sense, belonging and community matter to distance-learning students but for different reasons than for face-to-face students. The findings are relevant to other distance and face-to-face HE providers who are keen to engage students in virtual extracurricular spaces to support learning and facilitate community
An insight on time-use surveys: a case study on time poverty in Spain
Programa de Doctorado en Ciencias SocialesLĂnea de InvestigaciĂłn: Genero e IgualdadClave Programa: DSOCĂłdigo LĂnea: 59Historically speaking, time-use surveys are not a new survey method. They were first designed and used in the early years of the 20th century to understand that part of people's lives for which information was not available from conventional data sources such as national income, labour and employment statistics. From a feminist perspective, one of the main contributions of time-use surveys is that they have allowed "measuring" unpaid work, which until recently was concealed despite being essential for understanding gender inequalities-and inequalities in general-and labour market organisation.
Time-use surveys allow introducing and improving the measurement of poverty that emphasising gender differences and finding other perspectives that are far removed from the "traditional" economic ones based on male conceptions and understandings.
The main objective of this work it to provide some insights into how to improve time-use data and time-poverty indicators from a feminist perspective. In order to do this, we analyse time poverty in Spain using the last two Spanish time-use surveys. Although time surveys are a powerful tool to measure unpaid work, we have found significant limitations in the way data are collected and studies are carried out. We analyse the determinants that affect time poverty in Spain, and will look as well at children and older adults' time poverty, which help us make some policy recommendations.
At the same time this thesis aims at contributing to the theoretical framework of poverty in two original ways: 1) analysing the Spanish case, the concept of time poverty, and the methodology used to measure it in rich countries with different time-income dynamics; 2) analysing poverty from a different perspective, which enables an improvement in time-use statistics still very much driven by male standards of economic behaviour.
The main driver of this work is the awareness of the need to improve time-use surveys and their comparability, and of the possibility of carrying out an important amount of research by using time-use survey data. In this sense, this work aims at contributing to the discussion on how to improve time-use surveys from a feminist perspective through the analysis of Spanish time-use data.Universidad Pablo de Olavide de Sevilla. Departamento de EconomĂa, MĂ©todos Cuantitativos e Historia EconĂłmic
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