2,256 research outputs found

    A survey of random processes with reinforcement

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    The models surveyed include generalized P\'{o}lya urns, reinforced random walks, interacting urn models, and continuous reinforced processes. Emphasis is on methods and results, with sketches provided of some proofs. Applications are discussed in statistics, biology, economics and a number of other areas.Comment: Published at http://dx.doi.org/10.1214/07-PS094 in the Probability Surveys (http://www.i-journals.org/ps/) by the Institute of Mathematical Statistics (http://www.imstat.org

    From microscopic to macroscopic descriptions of cell\ud migration on growing domains

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    Cell migration and growth are essential components of the development of multicellular organisms. The role of various cues in directing cell migration is widespread, in particular, the role of signals in the environment in the control of cell motility and directional guidance. In many cases, especially in developmental biology, growth of the domain also plays a large role in the distribution of cells and, in some cases, cell or signal distribution may actually drive domain growth. There is a ubiquitous use of partial differential equations (PDEs) for modelling the time evolution of cellular density and environmental cues. In the last twenty years, a lot of attention has been devoted to connecting macroscopic PDEs with more detailed microscopic models of cellular motility, including models of directional sensing and signal transduction pathways. However, domain growth is largely omitted in the literature. In this paper, individual-based models describing cell movement and domain growth are studied, and correspondence with a macroscopic-level PDE describing the evolution of cell density is demonstrated. The individual-based models are formulated in terms of random walkers on a lattice. Domain growth provides an extra mathematical challenge by making the lattice size variable over time. A reaction-diffusion master equation formalism is generalised to the case of growing lattices and used in the derivation of the macroscopic PDEs

    Using mathematical models to help understand biological pattern formation

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    One of the characteristics of biological systems is their ability to produce and sustain spatial and spatio-temporal pattern. Elucidating the underlying mechanisms responsible for this phenomenon has been the goal of much experimental and theoretical research. This paper illustrates this area of research by presenting some of the mathematical models that have been proposed to account for pattern formation in biology and considering their implications.To cite this article: P.K. Maini, C. R. Biologies 327 (2004)

    Mathematical analysis and stability of a chemotaxis model with logistic term.

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    In this paper we study a non-linear system of dierential equations arising in chemotaxis. The system consists of a PDE that describes the evolution of a population and an ODE which models the concentration of a chemical substance. We study the number of steady states under suitable assumptions, the existence of one global solution to the evolution problem in terms of weak solutions and the stability of the steady states
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