Stem cell therapies for ischemic cardiovascular diseases

Myocardial infarction results in loss of cardiac muscle and deficiency in cardiac performance. Likewise, peripheral artery disease can result in critical limb ischemia leading to reduced mobility, non-healing ulcers, gangrene and amputation. Both of these common conditions diminish quality of life and enhance risk of mortality. Successful advances in treatment have led to more people surviving incidences of myocardial infarction or living with peripheral artery disease. However, the current treatments are inadequate in repairing ischemic tissue. Over the last 5 years, a vast number of patents have been submitted concerning the use of stem cells, which correlates with the exponential growth in stem cell publications. Exploiting stem cell therapy offers a real potential in replacing ischemic tissue with functional cells. In this paper, we review recent patents concerning stem cell therapy that have the potential to provide or potentiate novel treatment for ischemic cardiovascular disease. In addition, we evaluate the promise of the inventions by describing some clinical trials that are currently taking place, as well as considering how current research on ischemic cardiovascular disease may change the patent landscape in the future

A Human-Machine Interface Based on Eye Tracking for Controlling and Monitoring a Smart Home Using the Internet of Things

Não consta

Diagnostics of inflammatory bowel disease using fecal microbiota: Diagnostic markers and commercial potential

Mastergradsoppgave i næringsrettet bioteknologi, Avdeling for lærerutdanning og naturvitenskap, Høgskolen i Hedmark, 2010. Master of applied and commercial biotechnology.Establishing the diagnosis of Inflammatory Bowel Disease (IBD) with its two main sub forms Crohn‟s Disease (CD) and Ulcerative colitis (UC) are based on medical history, clinical evaluation, laboratory tests, endoscopy, radiology and histology. However no gold standard exists. The lack of appropriate diagnostic tools leads to delayed and incorrect treatment of IBD patients. A substantial amount of patients diagnosed as CD are later reclassified as UC and opposite. Also the type of colitis remains unclassified in many patients. In addition, non- IBD patients presenting with similar symptoms as IBD are unnecessarily investigated with invasive tests leading to increased hospitals costs. The cause of IBD is not yet completely described, but most evidence points to a combination of genetic predisposition, immunological factors, environmental triggers, and gastro intestinal (GI) microbes. However, neither the types of microbes responsible for the diseases nor changes in the microbiota as a result of the diseases have been sufficiently identified. The aim of this thesis was to evaluate the potential of using the fecal microbiota for IBD diagnostics. This was achieved through a combination of a literature study, lab study and investigations of the commercial potential including a patent search. The literature study revealed conflicting evidence related to the amounts of bacteria in IBD patients relative to controls. Nevertheless, a majority of the articles agreed in decreased amounts of Clostridia species and increased amounts of Gammaproteobacteria species in the GI microbiota of IBD patients. The lab study comprised an evaluation of a genetic test, GA-map™, commercialized by Genetic Analysis AS (GA). By using variable regions in the 16S rRNA gene, simultaneous detection and identification of multiple bacteria in a complex mixture of DNA is possible. Probes and analytic methods are suitable for several types of diagnostic tests among other IBD. A sequence analysis of fecal samples from 152 IBD patients and 105 non-IBD controls was performed. Significantly a probe detecting increased relative amounts of Proteobacteria and Bacteroidetes species was identified as a new possible diagnostic test for CD patients. A search in European and American patent databases revealed several patents related to IBD diagnostics. Especially important, a patent application from George Mason University comprised claims referring to IBD diagnostics by using the microbial community of the digestive tract and lumen. If issued, this application could influence the freedom to operate to companies focusing on bacterial markers in IBD diagnostics. Few other patents or patent applications from the search query include claims for identification of bacteria in fecal samples. A concluding remark from examining the commercial potential of IBD diagnostics in this thesis is to tailor make a diagnostic test separating IBD from irritating bowel syndrome (IBS), a common functional disease frequently confused with IBD. Based on estimations of price and profit per test, a €7Mill research budget was recommended for the normal case scenario. Finally it is concluded that development of a diagnostic test based on fecal microbiota has a commercial potential within the proposed framework

Progress in Landslide Research and Technology, Volume 1 Issue 2, 2022

This open access book provides an overview of the progress in landslide research and technology and is part of a book series of the International Consortium on Landslides (ICL). It gives an overview of recent progress in landslide research and technology for practical applications and the benefit for the society contributing to understanding and reducing landslide disaster risk

Innovation in a Circular Economy: Conceptual, empirical and policy underpinnings for transition through an eco-innovation pathway

As the world seeks answers to the defining challenges of climate change and environmental sustainability, several hypotheses are being canvased in the search for a solution to decouple economic growth and social development from resource exploitation. Among those, the circular economy (CE) emerged as an operational response defined by its opposition to a harvesting-wasting economic model, proposing instead restorative and regenerative activities. But reconfiguring existing paradigms is not trivial. Aligning innovation activities with more sustainable paths is a central requirement for the desired socio-techno-economic paradigm shift. This work proposes that a new pathway is needed for gearing the sustainable innovation agenda towards a CE, and foster structural change. CE-inducing eco-innovation (EI) must, however, be monitored and measured, and implications to socio-cultural agents, organisational strategies and policy priorities have to be bore in mind, if we are to ascertain if progress is being made. As CE and the EI – CE nexus research is still in its early days, this work adds to the discussion by contributing (1) to the theoretical development of these concepts and their interrelations; (2) to the empirical definition of pro CE EI proxies; and (3) to the prospective anticipation of CE developments. Within the sustainability debate, and using an innovation studies perspective, this research adopted a mixed methods approach, using both quantitative and qualitative methods such as literature reviews, bibliometrics, patent and trademark analysis (using the specific case of Portugal), and foresight techniques (Delphi study). The overall findings suggest that CE’s main ideas are arguably timely. CE’s establishment within the sustainability debate seems, nevertheless, dependent on overcoming short term barriers constraining its further development, of technological and economic nature, but also of a socio-cultural kind. CE is argued as a multidimensional, multi-actor approach reliant on “systemic transformative” innovation, thus dependent on a combination of “harder”, (technological, R&D-driven), and “softer” (non-technological change in social and business culture) knowledge. The empirical diagnosis of an innovation system’s pro circularity tendencies proved to be informative as to assess convergence to circularity. In the Portuguese case, it successfully shed light on ongoing dynamics related with signs of effective transformation towards CE activities, even if highlighting structural limitations associated with systemic failures regarding actors and networks. Redirecting innovation systems towards a more “circular” paradigm is, therefore, deeply dependent on an institutional “coordination role” enabling “framework conditions” directly linked to a systemic action. That is, associating bottom-up measures to top-down policies in a coherent strategic roadmap, in order to avoid mismatches and contradictory incentives. This pointed to the usefulness of rethinking innovation policy design. In one hand, to address market and system failures, leading to underinvestment and lack of connectivity in innovation. In the other hand, to promote the diffusion of CE related information for enterprises and civil society, in order to encourage market awareness and change mind-sets towards “circular” behaviours. As the conceptual and practical implementation challenge remains pressing, this work added important underpinnings for fine-tuning a CE inducing “policy mix”.Num mundo crescentemente interdependente, as alterações climáticas e a sustentabilidade ambiental são questões globais complexas. A importância de dissociar desenvolvimento da exploração de recursos tem propiciado um alargamento de horizontes a novos conceitos. Nesse contexto, a economia circular emergiu como uma resposta operacional, definida pela sua oposição ao modelo económico atual de exploração/desperdício. Contrapõe, ao invés, processos restaurativos e regenerativos. A reconfiguração dos paradigmas existentes, a este nível, não é, contudo, algo trivial. Uma vez que o alinhamento das atividades de inovação com objetivos mais sustentáveis é um requisito central na alteração de paradigma sócio-tecno-económico, este trabalho foca a necessidade de orientar a agenda de inovação para a “circularidade”. A eco-inovação pro-circularidade deve, no entanto, ser monitorizada e medida, e as implicações para os agentes socioculturais, estratégias organizacionais e prioridades políticas levadas em conta, se quisermos verificar o seu progresso. Nesse âmbito, pretendeu-se contribuir para o debate em curso contribuindo para: 1) uma melhor compreensão teórica do papel da eco-inovação na implementação de uma economia circular; 2) a definição e teste de proxies empíricas de inovação pro-circularidade; 3) o desenvolvimento de uma visão prospetiva de futuros desenvolvimentos nesta área. No contexto do debate da sustentabilidade, e usando uma perspetiva baseada nos estudos da inovação, foram adotados métodos quantitativos e qualitativos, incluindo revisões de literatura, métodos bibliométricos, análise de patentes e de marcas comerciais (usando o caso específico de Portugal), assim como o uso do método prospetivo Delphi. As conclusões gerais sugerem que as principais ideias da economia circular são indiscutivelmente oportunas. Dentro do debate da sustentabilidade o estabelecimento de uma economia circular parece, no entanto, dependente de se vencerem barreiras de curto prazo, de natureza tecnológica, económica e sociocultural. A abordagem preconizada pela economia circular é assim tida como multidimensional, multi-ator, dependente de uma inovação sistémica "transformadora”, compreendendo não só inovação tecnológica, mas também mudanças institucionais abrangentes quanto a políticas públicas, mercados e práticas sociais. O diagnóstico empírico das tendências pró-circularidade de um sistema de inovação provou ser informativo nessa avaliação. No caso português, permitiu conhecer as atuais dinâmicas, sublinhando sinais de transformação efetivas em direção a atividades circulares, ao mesmo tempo que assinalou as limitações estruturais associadas a falhas sistémicas quanto aos atores e redes (interconexões). Redirecionar os sistemas de inovação para um paradigma mais “circular” é, portanto, profundamente dependente de um “papel de coordenação” institucional que permita “condições de enquadramento” diretamente ligadas a uma ação sistémica. Isto é, associando medidas bottom-up e top-down num roteiro estratégico coerente, a fim de evitar desequilíbrios e incentivos contraditórios. Importa, por isso, repensar igualmente os instrumentos das políticas de inovação. Por um lado, resolvendo falhas de mercado e sistema, que levam a sub-investimento e falta de conectividade. Por outro, promovendo a difusão de informação para empresas e sociedade civil, a fim de estimular a conscientização e mudar mentalidades em relação a comportamentos “circulares”. O desafio de implementação continua a ser premente, este trabalho pretendeu contudo acrescentar ao debate tendo em vista contribuir para o ajuste do “mix de políticas” indutoras de circularidade