3,929 research outputs found
High-throughput screening of encapsulated islets using wide-field lens-free on-chip imaging
Islet microencapsulation is a promising solution to diabetes treatment, but
its quality control based on manual microscopic inspection is extremely
low-throughput, highly variable and laborious. This study presents a
high-throughput islet-encapsulation quality screening system based on lens-free
on-chip imaging with a wide field-of-view of 18.15 cm^2, which is more than 100
times larger than that of a lens-based optical microscope, enabling it to image
and analyze ~8,000 microcapsules in a single frame. Custom-written image
reconstruction and processing software provides the user with clinically
important information, such as microcapsule count, size, intactness, and
information on whether each capsule contains an islet. This high-throughput and
cost-effective platform can be useful for researchers to develop better
encapsulation protocols as well as perform quality control prior to
transplantation
Future large-scale water-Cherenkov detector
MEMPHYS (MEgaton Mass PHYSics) is a proposed large-scale water-Cherenkov
experiment to be performed deep underground. It is dedicated to nucleon decay
searches and the detection of neutrinos from supernovae, solar, and atmospheric
neutrinos, as well as neutrinos from a future beam to measure the CP violating
phase in the leptonic sector and the mass hierarchy. This paper provides an
overview of the latest studies on the expected performance of MEMPHYS in view
of detailed estimates of its physics reach, mainly concerning neutrino beams
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