113,346 research outputs found
Innovation as a Nonlinear Process, the Scientometric Perspective, and the Specification of an "Innovation Opportunities Explorer"
The process of innovation follows non-linear patterns across the domains of
science, technology, and the economy. Novel bibliometric mapping techniques can
be used to investigate and represent distinctive, but complementary
perspectives on the innovation process (e.g., "demand" and "supply") as well as
the interactions among these perspectives. The perspectives can be represented
as "continents" of data related to varying extents over time. For example, the
different branches of Medical Subject Headings (MeSH) in the Medline database
provide sources of such perspectives (e.g., "Diseases" versus "Drugs and
Chemicals"). The multiple-perspective approach enables us to reconstruct facets
of the dynamics of innovation, in terms of selection mechanisms shaping
localizable trajectories and/or resulting in more globalized regimes. By
expanding the data with patents and scholarly publications, we demonstrate the
use of this multi-perspective approach in the case of RNA Interference (RNAi).
The possibility to develop an "Innovation Opportunities Explorer" is specified.Comment: Technology Analysis and Strategic Management (forthcoming in 2013
Monitoring land use changes using geo-information : possibilities, methods and adapted techniques
Monitoring land use with geographical databases is widely used in decision-making. This report presents the possibilities, methods and adapted techniques using geo-information in monitoring land use changes. The municipality of Soest was chosen as study area and three national land use databases, viz. Top10Vector, CBS land use statistics and LGN, were used. The restrictions of geo-information for monitoring land use changes are indicated. New methods and adapted techniques improve the monitoring result considerably. Providers of geo-information, however, should coordinate on update frequencies, semantic content and spatial resolution to allow better possibilities of monitoring land use by combining data sets
Bibliometric Perspectives on Medical Innovation using the Medical Subject Headings (MeSH) of PubMed
Multiple perspectives on the nonlinear processes of medical innovations can
be distinguished and combined using the Medical Subject Headings (MeSH) of the
Medline database. Focusing on three main branches-"diseases," "drugs and
chemicals," and "techniques and equipment"-we use base maps and overlay
techniques to investigate the translations and interactions and thus to gain a
bibliometric perspective on the dynamics of medical innovations. To this end,
we first analyze the Medline database, the MeSH index tree, and the various
options for a static mapping from different perspectives and at different
levels of aggregation. Following a specific innovation (RNA interference) over
time, the notion of a trajectory which leaves a signature in the database is
elaborated. Can the detailed index terms describing the dynamics of research be
used to predict the diffusion dynamics of research results? Possibilities are
specified for further integration between the Medline database, on the one
hand, and the Science Citation Index and Scopus (containing citation
information), on the other.Comment: forthcoming in the Journal of the American Society for Information
Science and Technolog
The computer revolution in science: steps towards the realization of computer-supported discovery environments
The tools that scientists use in their search processes together form so-called discovery environments. The promise of artificial intelligence and other branches of computer science is to radically transform conventional discovery environments by equipping scientists with a range of powerful computer tools including large-scale, shared knowledge bases and discovery programs. We will describe the future computer-supported discovery environments that may result, and illustrate by means of a realistic scenario how scientists come to new discoveries in these environments. In order to make the step from the current generation of discovery tools to computer-supported discovery environments like the one presented in the scenario, developers should realize that such environments are large-scale sociotechnical systems. They should not just focus on isolated computer programs, but also pay attention to the question how these programs will be used and maintained by scientists in research practices. In order to help developers of discovery programs in achieving the integration of their tools in discovery environments, we will formulate a set of guidelines that developers could follow
DNA expression microarrays may be the wrong tool to identify biological pathways
DNA microarray expression signatures are expected to provide new insights into patho- physiological pathways. Numerous variant statistical methods have been described for each step of the signal analysis. We employed five similar statistical tests on the same data set at the level of gene selection. Inter-test agreement for the identification of biological pathways in BioCarta, KEGG and Reactome was calculated using Cohen’s k- score. The identification of specific biological pathways showed only moderate agreement (0.30 < k < 0.79) between the analysis methods used. Pathways identified by microarrays must be treated cautiously as they vary according to the statistical method used
- …