A Source Domain Extension Method for Inductive Transfer Learning Based on Flipping Output

Transfer learning aims for high accuracy by applying knowledge of source domains for which data collection is easy in order to target domains where data collection is difficult, and has attracted attention in recent years because of its significant potential to enable the application of machine learning to a wide range of real-world problems. However, since the technique is user-dependent, with data prepared as a source domain which in turn becomes a knowledge source for transfer learning, it often involves the adoption of inappropriate data. In such cases, the accuracy may be reduced due to “negative transfer.” Thus, in this paper, we propose a novel transfer learning method that utilizes the flipping output technique to provide multiple labels in the source domain. The accuracy of the proposed method is statistically demonstrated to be significantly better than that of the conventional transfer learning method, and its effect size is as high as 0.9, showing high performance

Deep learning in food category recognition

Integrating artificial intelligence with food category recognition has been a field of interest for research for the past few decades. It is potentially one of the next steps in revolutionizing human interaction with food. The modern advent of big data and the development of data-oriented fields like deep learning have provided advancements in food category recognition. With increasing computational power and ever-larger food datasets, the approach’s potential has yet to be realized. This survey provides an overview of methods that can be applied to various food category recognition tasks, including detecting type, ingredients, quality, and quantity. We survey the core components for constructing a machine learning system for food category recognition, including datasets, data augmentation, hand-crafted feature extraction, and machine learning algorithms. We place a particular focus on the field of deep learning, including the utilization of convolutional neural networks, transfer learning, and semi-supervised learning. We provide an overview of relevant studies to promote further developments in food category recognition for research and industrial applicationsMRC (MC_PC_17171)Royal Society (RP202G0230)BHF (AA/18/3/34220)Hope Foundation for Cancer Research (RM60G0680)GCRF (P202PF11)Sino-UK Industrial Fund (RP202G0289)LIAS (P202ED10Data Science Enhancement Fund (P202RE237)Fight for Sight (24NN201);Sino-UK Education Fund (OP202006)BBSRC (RM32G0178B8

Deep Learning for Detection and Segmentation in High-Content Microscopy Images

High-content microscopy led to many advances in biology and medicine. This fast emerging technology is transforming cell biology into a big data driven science. Computer vision methods are used to automate the analysis of microscopy image data. In recent years, deep learning became popular and had major success in computer vision. Most of the available methods are developed to process natural images. Compared to natural images, microscopy images pose domain specific challenges such as small training datasets, clustered objects, and class imbalance. In this thesis, new deep learning methods for object detection and cell segmentation in microscopy images are introduced. For particle detection in fluorescence microscopy images, a deep learning method based on a domain-adapted Deconvolution Network is presented. In addition, a method for mitotic cell detection in heterogeneous histopathology images is proposed, which combines a deep residual network with Hough voting. The method is used for grading of whole-slide histology images of breast carcinoma. Moreover, a method for both particle detection and cell detection based on object centroids is introduced, which is trainable end-to-end. It comprises a novel Centroid Proposal Network, a layer for ensembling detection hypotheses over image scales and anchors, an anchor regularization scheme which favours prior anchors over regressed locations, and an improved algorithm for Non-Maximum Suppression. Furthermore, a novel loss function based on Normalized Mutual Information is proposed which can cope with strong class imbalance and is derived within a Bayesian framework. For cell segmentation, a deep neural network with increased receptive field to capture rich semantic information is introduced. Moreover, a deep neural network which combines both paradigms of multi-scale feature aggregation of Convolutional Neural Networks and iterative refinement of Recurrent Neural Networks is proposed. To increase the robustness of the training and improve segmentation, a novel focal loss function is presented. In addition, a framework for black-box hyperparameter optimization for biomedical image analysis pipelines is proposed. The framework has a modular architecture that separates hyperparameter sampling and hyperparameter optimization. A visualization of the loss function based on infimum projections is suggested to obtain further insights into the optimization problem. Also, a transfer learning approach is presented, which uses only one color channel for pre-training and performs fine-tuning on more color channels. Furthermore, an approach for unsupervised domain adaptation for histopathological slides is presented. Finally, Galaxy Image Analysis is presented, a platform for web-based microscopy image analysis. Galaxy Image Analysis workflows for cell segmentation in cell cultures, particle detection in mice brain tissue, and MALDI/H&E image registration have been developed. The proposed methods were applied to challenging synthetic as well as real microscopy image data from various microscopy modalities. It turned out that the proposed methods yield state-of-the-art or improved results. The methods were benchmarked in international image analysis challenges and used in various cooperation projects with biomedical researchers

Data-Efficient Machine Learning with Focus on Transfer Learning

Machine learning (ML) has attracted a significant amount of attention from the artifi- cial intelligence community. ML has shown state-of-art performance in various fields, such as signal processing, healthcare system, and natural language processing (NLP). However, most conventional ML algorithms suffer from three significant difficulties: 1) insufficient high-quality training data, 2) costly training process, and 3) domain dis- crepancy. Therefore, it is important to develop solutions for these problems, so the future of ML will be more sustainable. Recently, a new concept, data-efficient ma- chine learning (DEML), has been proposed to deal with the current bottlenecks of ML. Moreover, transfer learning (TL) has been considered as an effective solution to address the three shortcomings of conventional ML. Furthermore, TL is one of the most active areas in the DEML. Over the past ten years, significant progress has been made in TL. In this dissertation, I propose to address the three problems by developing a software- oriented framework and TL algorithms. Firstly, I introduce a DEML framework and a evaluation system. Moreover, I present two novel TL algorithms and applications on real-world problems. Furthermore, I will first present the first well-defined DEML framework and introduce how it can address the challenges in ML. After that, I will give an updated overview of the state-of-the-art and open challenges in the TL. I will then introduce two novel algorithms for two of the most challenging TL topics: distant domain TL and cross-modality TL (image-text). A detailed algorithm introduction and preliminary results on real-world applications (Covid-19 diagnosis and image clas- sification) will be presented. Then, I will discuss the current trends in TL algorithms and real-world applications. Lastly, I will present the conclusion and future research directions