The role of information in therapeutic decision-making for adults living with Multiple Sclerosis (MS)

Background: People with MS (pwMS) are confronted with 16 therapies. These come with risks that have led to drug withdrawals and changes to prescribing regulations. Patient autonomy is seen as desirable and has challenged the role of the health care professional (HCP). Greater scrutiny of the decisional process is necessary to determine if complex decision-making can be influenced. Methods: i) Attendees to an MS conference (n=105) and a cohort of patients on treatment (n=76) were contacted about their current treatment status and if they had decisional conflict (DC). ii) Prospective study (n=73) of pwMS offered treatment, used instruments to map pwMS through their decision post-consultation. iii) Results informed a film aimed at pwMS (n=1001) and a comparator group without MS (n=148). Participants reviewed the film with the primary aim of measuring understanding of the concepts portrayed. Results: i) Data from the cohorts in methods i-ii (n=254) were compared. The treatment status ‘not satisfied’ was present in 113/254 (44%) and 135/254 (53%) had DC. ii) DC was significantly increased in a treatment naïve subgroup 75% (27/36), p=0.013. iii) In the ‘offered treatment’ study, making a treatment decision took a mean of 29 days (range 0-308). Multivariate regression analysis found those with less confidence in their healthcare decision-making were more likely to have DC (n=72, SURE scale; adjusted R2 0.11, p=0.02; SURE-subscale adjusted R2 0.04 p=0.04; DCG adjusted R2 0.04 p=0.04). iv) The neurologist perceived significantly more consensus during the consultation (39.24±6.54) than pwMS (31.22±10.64; p<0.001). A multivariate regression analysis found that shared decision making (SDM) was associated with lower DC alongside patient engagement (n=67, adjusted R2 0.382; p<0.001). v) There was a high level of film understanding in the total population (85%). vi) A multivariate regression analysis found that ‘education’ was associated with film ‘understanding’ (n=892, adjusted R2 0.023, p=0.000). This meant having less education was associated with increased understanding. A one point increase in education was associated with a .170 reduction in understanding. Conclusions: i) PwMS have high levels of DC when making treatment decisions. ii) Low engagement is associated with increased DC but an HCP consultation with good SDM is associated with lower DC. iii) A film produced a high level of understanding in both MS and non-MS populations. Those less educated had the highest understanding overall.Open Acces

The Internet of Robotic Things:A review of concept, added value and applications

The Internet of Robotic Things is an emerging vision that brings together pervasive sensors and objects with robotic and autonomous systems. This survey examines how the merger of robotic and Internet of Things technologies will advance the abilities of both the current Internet of Things and the current robotic systems, thus enabling the creation of new, potentially disruptive services. We discuss some of the new technological challenges created by this merger and conclude that a truly holistic view is needed but currently lacking.Funding Agency:imec ACTHINGS High Impact initiative</p

A framework for Model-Driven Engineering of resilient software-controlled systems

AbstractEmergent paradigms of Industry 4.0 and Industrial Internet of Things expect cyber-physical systems to reliably provide services overcoming disruptions in operative conditions and adapting to changes in architectural and functional requirements. In this paper, we describe a hardware/software framework supporting operation and maintenance of software-controlled systems enhancing resilience by promoting a Model-Driven Engineering (MDE) process to automatically derive structural configurations and failure models from reliability artifacts. Specifically, a reflective architecture developed around digital twins enables representation and control of system Configuration Items properly derived from SysML Block Definition Diagrams, providing support for variation. Besides, a plurality of distributed analytic agents for qualitative evaluation over executable failure models empowers the system with runtime self-assessment and dynamic adaptation capabilities. We describe the framework architecture outlining roles and responsibilities in a System of Systems perspective, providing salient design traits about digital twins and data analytic agents for failure propagation modeling and analysis. We discuss a prototype implementation following the MDE approach, highlighting self-recovery and self-adaptation properties on a real cyber-physical system for vehicle access control to Limited Traffic Zones

Plot-based urbanism and urban morphometrics : measuring the evolution of blocks, street fronts and plots in cities

Generative urban design has been always conceived as a creation-centered process, i.e. a process mainly concerned with the creation phase of a spatial transformation. We argue that, though the way we create a space is important, how that space evolves in time is ways more important when it comes to providing livable places gifted by identity and sense of attachment. We are presenting in this paper this idea and its major consequences for urban design under the title of “Plot-Based Urbanism”. We will argue that however, in order for a place to be adaptable in time, the right structure must be provided “by design” from the outset. We conceive urban design as the activity aimed at designing that structure. The force that shapes (has always shaped) the adaptability in time of livable urban places is the restless activity of ordinary people doing their own ordinary business, a kind of participation to the common good, which has hardly been acknowledged as such, that we term “informal participation”. Investigating what spatial components belong to the spatial structure and how they relate to each other is of crucial importance for urban design and that is the scope of our research. In this paper a methodology to represent and measure form-related properties of streets, blocks, plots and buildings in cities is presented. Several dozens of urban blocks of different historic formation in Milan (IT) and Glasgow (UK) are surveyed and analyzed. Effort is posed to identify those spatial properties that are shared by clusters of cases in history and therefore constitute the set of spatial relationships that determine the morphological identity of places. To do so, we investigate the analogy that links the evolution of urban form as a cultural construct to that of living organisms, outlining a conceptual framework of reference for the further investigation of “the DNA of places”. In this sense, we identify in the year 1950 the nominal watershed that marks the first “speciation” in urban history and we find that factors of location/centrality, scale and street permeability are the main drivers of that transition towards the entirely new urban forms of contemporary cities

A holonic manufacturing architecture for line-less mobile assembly systems operations planning and control

Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Automação e Sistemas, Florianópolis, 2022.O Line-Less Mobile Assembly Systems (LMAS) é um paradigma de fabricação que visa maximizar a resposta às tendências do mercado através de configurações adaptáveis de fábrica utilizando recursos de montagem móvel. Tais sistemas podem ser caracterizados como holonic manufacturing systems (HMS), cujas chamadas holonic control architecture (HCA) são recentemente retratadas como abordagens habilitadoras da Indústria 4.0 devido a suas relações de entidades temporárias (hierárquicas e/ou heterárquicas). Embora as estruturas de referência HCA como PROSA ou ADACOR/ADACOR² tenham sido muito discutidas na literatura, nenhuma delas pode ser aplicada diretamente ao contexto LMAS. Assim, esta dissertação visa responder à pergunta \"Como uma arquitetura de produção e sistema de controle LMAS precisa ser projetada?\" apresentando os modelos de projeto de arquitetura desenvolvidos de acordo com as etapas da metodologia para desenvolvimento de sistemas holônicos multi-agentes ANEMONA. A fase de análise da ANEMONA resulta em uma especificação do caso de uso, requisitos, objetivos do sistema, simplificações e suposições. A fase de projeto resulta nos modelos de organização, interação e agentes, seguido de uma breve análise de sua cobertura comportamental. O resultado da fase de implementação é um protótipo (realizado com o Robot Operation System) que implementa os modelos ANEMONA e uma ontologia LMAS, que reutiliza elementos de ontologias de referência do domínio de manufatura. A fim de testar o protótipo, um algoritmo para geração de dados para teste baseado na complexidade dos produtos e na flexibilidade do chão de fábrica é apresentado. A validação qualitativa dos modelos HCA é baseada em como o HCA proposto atende a critérios específicos para avaliar sistemas HCA. A validação é complementada por uma análise quantitativa considerando o comportamento dos modelos implementados durante a execução normal e a execução interrompida (e.g. equipamento defeituoso) em um ambiente simulado. A validação da execução normal concentra-se no desvio de tempo entre as agendas planejadas e executadas, o que provou ser em média irrelevante dentro do caso simulado considerando a ordem de magnitude das operações típicas demandadas. Posteriormente, durante a execução do caso interrompido, o sistema é testado sob a simulação de uma falha, onde duas estratégias são aplicadas, LOCAL\_FIX e REORGANIZATION, e seu resultado é comparado para decidir qual é a opção apropriada quando o objetivo é reduzir o tempo total de execução. Finalmente, é apresentada uma análise sobre a cobertura desta dissertação culminando em diretrizes que podem ser vistas como uma resposta possível (entre muitas outras) para a questão de pesquisa apresentada. Além disso, são apresentados pontos fortes e fracos dos modelos desenvolvidos, e possíveis melhorias e idéias para futuras contribuições para a implementação de sistemas de controle holônico para LMAS.Abstract: The Line-Less Mobile Assembly Systems (LMAS) is a manufacturing paradigm aiming to maximize responsiveness to market trends (product-individualization and ever-shortening product lifecycles) by adaptive factory configurations utilizing mobile assembly resources. Such responsive systems can be characterized as holonic manufacturing systems (HMS), whose so-called holonic control architectures (HCA) are recently portrayed as Industry 4.0-enabling approaches due to their mixed-hierarchical and -heterarchical temporary entity relationships. They are particularly suitable for distributed and flexible systems as the Line-Less Mobile Assembly or Matrix-Production, as they meet reconfigurability capabilities. Though HCA reference structures as PROSA or ADACOR/ADACOR² have been heavily discussed in the literature, neither can directly be applied to the LMAS context. Methodologies such as ANEMONA provide guidelines and best practices for the development of holonic multi-agent systems. Accordingly, this dissertation aims to answer the question \"How does an LMAS production and control system architecture need to be designed?\" presenting the architecture design models developed according to the steps of the ANEMONA methodology. The ANEMONA analysis phase results in a use case specification, requirements, system goals, simplifications, and assumptions. The design phase results in an LMAS architecture design consisting of the organization, interaction, and agent models followed by a brief analysis of its behavioral coverage. The implementation phase result is an LMAS ontology, which reuses elements from the widespread manufacturing domain ontologies MAnufacturing's Semantics Ontology (MASON) and Manufacturing Resource Capability Ontology (MaRCO) enriched with essential holonic concepts. The architecture approach and ontology are implemented using the Robot Operating System (ROS) robotic framework. In order to create test data sets validation, an algorithm for test generation based on the complexity of products and the shopfloor flexibility is presented considering a maximum number of operations per work station and the maximum number of simultaneous stations. The validation phase presents a two-folded validation: qualitative and quantitative. The qualitative validation of the HCA models is based on how the proposed HCA attends specific criteria for evaluating HCA systems (e.g., modularity, integrability, diagnosability, fault tolerance, distributability, developer training requirements). The validation is complemented by a quantitative analysis considering the behavior of the implemented models during the normal execution and disrupted execution (e.g.; defective equipment) in a simulated environment (in the form of a software prototype). The normal execution validation focuses on the time drift between the planned and executed schedules, which has proved to be irrelevant within the simulated case considering the order of magnitude of the typical demanded operations. Subsequently, during the disrupted case execution, the system is tested under the simulation of a failure, where two strategies are applied, LOCAL\_FIX and REORGANIZATION, and their outcome is compared to decide which one is the appropriate option when the goal is to reduce the overall execution time. Ultimately, it is presented an analysis about the coverage of this dissertation culminating into guidelines that can be seen as one possible answer (among many others) for the presented research question. Furthermore, strong and weak points of the developed models are presented, and possible improvements and ideas for future contributions towards the implementation of holonic control systems for LMAS

Analysis and evaluation of multi-agent systems for digital production planning and control

Industrial manufacturing companies have different IT control functions that can be represented with a so-called hierarchical automation pyramid. While these conventional software systems especially support the mass production with consistent demand, the future project “Industry 4.0” focuses on customer-oriented and adaptable production processes. In order to move from conventional production systems to a factory of the future, the control levels must be redistributed. With the help of cyber-physical production systems, an interoperable architecture must be, implemented which removes the hierarchical connection of the former control levels. The accompanied digitalisation of industrial companies makes the transition to modular production possible. At the same time, the requirements for production planning and control are increasing, which can be solved with approaches such as multi-agent systems (MASs). These software solutions are autonomous and intelligent objects with a distinct collaborative ability. There are different modelling methods, communication and interaction structures, as well as different development frameworks for these new systems. Since multi-agent systems have not yet been established as an industrial standard due to their high complexity, they are usually only tested in simulations. In this bachelor thesis, a detailed literature review on the topic of MASs in the field of production planning and control is presented. In addition, selected multi-agent approaches are evaluated and compared using specific classification criteria. In addition, the applicability of using these systems in digital and modular production is assessed

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N/ACustomer experience is one strategic option for organisations wishing to differentiate their service offering. Little research however has been conducted to explain how service design and management practices influence customer experience in non-hedonic contexts, settings in which the objectives for the design of the delivery system are not experiential. The objective of this research is to address this gap in academic knowledge. The conceptual framework used as the basis of the empirical research demonstrates how four experience mechanism constructs, incorporated into the design of the delivery system, facilitate the customer’s involvement in the delivery of the service and influence how they perceive the experience that emerges as a result. To explore the relevance of the framework two case studies were conducted. Data was collected principally through interviews with employees working at various levels throughout the organisations hierarchy and with customers. Observations and secondary source material also provided additional evidence. The thesis provides an original and distinct contribution to knowledge, through three main findings: Firstly, the research found evidence that the conceptual framework was relevant to the design of the delivery system and in customers’ perception of their experience. This challenges assumptions in existing literature that experience might not be a relevant design consideration in non-hedonic service contexts. Secondly, the findings provide a point of distinction between experiences in hedonic and non-hedonic contexts. Finally the study extends experience design theory demonstrating how in the contexts studied, the experience mechanisms act as antecedents for the experience a customer perceives. Whilst conducting only two case studies limits the impact of the findings, the propositions formulated to explain the key themes identified, can be used as a vehicle through which future quantitative research can be carried out, therefore extending the generalisability of the study beyond the contexts studied.N/

Theoretical concepts of consumer resilience to online privacy violation

Resilience is a multifaceted concept used to explain both system and individual behavior across disciplines. Although definitions and research concepts of resilience vary significantly, resilience has become a boundary object in diverse academic fields calling for a holistic approach. This work aims to elaborate the theoretical concepts that might be applied in the research of consumer resilience to online privacy violation, a new and unexplored aspect of consumer behavior in the digital environment. It contributes to the privacy resilience debate and lays the groundwork for developing a conceptual model of online consumer resilience that would explore how individual behavior is affected after online privacy violation occurrence

Theoretical concepts of consumer resilience to online privacy violation

Resilience is a multifaceted concept used to explain both system and individual behavior across disciplines. Although definitions and research concepts of resilience vary significantly, resilience has become a boundary object in diverse academic fields calling for a holistic approach. This work aims to elaborate the theoretical concepts that might be applied in the research of consumer resilience to online privacy violation, a new and unexplored aspect of consumer behavior in the digital environment. It contributes to the privacy resilience debate and lays the groundwork for developing a conceptual model of online consumer resilience that would explore how individual behavior is affected after online privacy violation occurrence