8,782 research outputs found

    Spatial epidemiology of a highly transmissible disease in urban neighbourhoods: Using COVID-19 outbreaks in Toronto as a case study

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    The emergence of infectious diseases in an urban area involves a complex interaction between the socioecological processes in the neighbourhood and urbanization. As a result, such an urban environment can be the incubator of new epidemics and spread diseases more rapidly in densely populated areas than elsewhere. Most recently, the Coronavirus-19 (COVID-19) pandemic has brought unprecedented challenges around the world. Toronto, the capital city of Ontario, Canada, has been severely impacted by COVID-19. Understanding the spatiotemporal patterns and the key drivers of such patterns is imperative for designing and implementing an effective public health program to control the spread of the pandemic. This dissertation was designed to contribute to the global research effort on the COVID-19 pandemic by conducting spatial epidemiological studies to enhance our understanding of the disease's epidemiology in a spatial context to guide enhancing the public health strategies in controlling the disease. Comprised of three original research manuscripts, this dissertation focuses on the spatial epidemiology of COVID-19 at a neighbourhood scale in Toronto. Each manuscript makes scientific contributions and enhances our knowledge of how interactions between different socioecological processes in the neighbourhood and urbanization can influence spatial spread and patterns of COVID-19 in Toronto with the application of novel and advanced methodological approaches. The findings of the outcomes of the analyses are intended to contribute to the public health policy that informs neighbourhood-based disease intervention initiatives by the public health authorities, local government, and policymakers. The first manuscript analyzes the globally and locally variable socioeconomic drivers of COVID-19 incidence and examines how these relationships vary across different neighbourhoods. In the global model, lower levels of education and the percentage of immigrants were found to have a positive association with increased risk for COVID-19. This study provides the methodological framework for identifying the local variations in the association between risk for COVID-19 and socioeconomic factors in an urban environment by applying a local multiscale geographically weighted regression (MGWR) modelling approach. The MGWR model is an improvement over the methods used in earlier studies of COVID-19 in identifying local variations of COVID-19 by incorporating a correction factor for the multiple testing problem in the geographically weighted regression models. The second manuscript quantifies the associations between COVID-19 cases and urban socioeconomic and land surface temperature (LST) at the neighbourhood scale in Toronto. Four spatiotemporal Bayesian hierarchical models with spatial, temporal, and varying space-time interaction terms are compared. The results of this study identified the seasonal trends of COVID-19 risk, where the spatiotemporal trends show increasing, decreasing, or stable patterns, and identified area-specific spatial risk for targeted interventions. Educational level and high land surface temperature are shown to have a positive association with the risk for COVID-19. In this study, high spatial and temporal resolution satellite images were used to extract LST, and atmospheric corrections methods were applied to these images by adopting a land surface emissivity (LSE) model, which provided a high estimation accuracy. The methodological approach of this work will help researchers understand how to acquire long time-series data of LST at a spatial scale from satellite images, develop methodological approaches for atmospheric correction and create the environmental data with a high estimation accuracy to fit into modelling disease. Applying to policy, the findings of this study can inform the design and implementation of urban planning strategies and programs to control disease risks. The third manuscript developed a novel approach for visualization of the spread of infectious disease outbreaks by incorporating neighbourhood networks and the time-series data of the disease at the neighbourhood level. The findings of the model provide an understanding of the direction and magnitude of spatial risk for the outbreak and guide for the importance of early intervention in order to stop the spread of the outbreak. The manuscript also identified hotspots using incidence rate and disease persistence, the findings of which may inform public health planners to develop priority-based intervention plans in a resource constraint situation

    Computational and experimental studies on the reaction mechanism of bio-oil components with additives for increased stability and fuel quality

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    As one of the world’s largest palm oil producers, Malaysia encountered a major disposal problem as vast amount of oil palm biomass wastes are produced. To overcome this problem, these biomass wastes can be liquefied into biofuel with fast pyrolysis technology. However, further upgradation of fast pyrolysis bio-oil via direct solvent addition was required to overcome it’s undesirable attributes. In addition, the high production cost of biofuels often hinders its commercialisation. Thus, the designed solvent-oil blend needs to achieve both fuel functionality and economic targets to be competitive with the conventional diesel fuel. In this thesis, a multi-stage computer-aided molecular design (CAMD) framework was employed for bio-oil solvent design. In the design problem, molecular signature descriptors were applied to accommodate different classes of property prediction models. However, the complexity of the CAMD problem increases as the height of signature increases due to the combinatorial nature of higher order signature. Thus, a consistency rule was developed reduce the size of the CAMD problem. The CAMD problem was then further extended to address the economic aspects via fuzzy multi-objective optimisation approach. Next, a rough-set based machine learning (RSML) model has been proposed to correlate the feedstock characterisation and pyrolysis condition with the pyrolysis bio-oil properties by generating decision rules. The generated decision rules were analysed from a scientific standpoint to identify the underlying patterns, while ensuring the rules were logical. The decision rules generated can be used to select optimal feedstock composition and pyrolysis condition to produce pyrolysis bio-oil of targeted fuel properties. Next, the results obtained from the computational approaches were verified through experimental study. The generated pyrolysis bio-oils were blended with the identified solvents at various mixing ratio. In addition, emulsification of the solvent-oil blend in diesel was also conducted with the help of surfactants. Lastly, potential extensions and prospective work for this study have been discuss in the later part of this thesis. To conclude, this thesis presented the combination of computational and experimental approaches in upgrading the fuel properties of pyrolysis bio-oil. As a result, high quality biofuel can be generated as a cleaner burning replacement for conventional diesel fuel

    Beam scanning by liquid-crystal biasing in a modified SIW structure

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    A fixed-frequency beam-scanning 1D antenna based on Liquid Crystals (LCs) is designed for application in 2D scanning with lateral alignment. The 2D array environment imposes full decoupling of adjacent 1D antennas, which often conflicts with the LC requirement of DC biasing: the proposed design accommodates both. The LC medium is placed inside a Substrate Integrated Waveguide (SIW) modified to work as a Groove Gap Waveguide, with radiating slots etched on the upper broad wall, that radiates as a Leaky-Wave Antenna (LWA). This allows effective application of the DC bias voltage needed for tuning the LCs. At the same time, the RF field remains laterally confined, enabling the possibility to lay several antennas in parallel and achieve 2D beam scanning. The design is validated by simulation employing the actual properties of a commercial LC medium

    OBSERVATIONAL CAUSAL INFERENCE FOR NETWORK DATA SETTINGS

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    Observational causal inference (OCI) has shown significant promise in recent years, both as a tool for improving existing machine learning techniques and as an avenue to aid decision makers in applied areas, such as health and climate science. OCI relies on a key notion, identification, which links the counterfactual of interest to the observed data via a set of assumptions. Historically, OCI has relied on unrealistic assumptions, such as the ’no latent confounders’ assumption. To address this, Huang and Valtorta (2006) and Shpitser and Pearl (2006) provided sound and complete algorithms for identification of causal effects in causal directed acyclic graphs with latent variables. Nevertheless, these algorithms can only handle relatively simple causal queries. In this dissertation, I will detail my contributions which generalize identification theory in key directions. I will describe theory which enables identification of causal effects when i) data do not satisfy the ’independent and identically distributed’ assumption, as in vaccine or social network data, and ii) the intervention of interest is a function of other model variables, as in off-line, off-policy learning, iii) when these two complicated settings intersect. Additionally, I will highlight some novel ways to conceive of interventions in networks. I will conclude with a discussion of future directions

    Optimal Robust Network Design: Formulations and Algorithms for Maximizing Algebraic Connectivity

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    This paper focuses on the design of edge-weighted networks, whose robustness is characterized by maximizing algebraic connectivity, or the smallest non-zero eigenvalue of the Laplacian matrix. This problem is motivated by the application of cooperative localization for accurately estimating positions of autonomous vehicles by choosing a set of relative position measurements and establishing associated communication links. We also examine an associated problem where every robot is limited by payload, budget, and communication to pick no more than a specified number of relative position measurements. The basic underlying formulation for these problems is nonlinear and is known to be NP-hard. We solve this network design problem by formulating it as a mixed-integer semi-definite program (MISDP) and reformulating it into a mixed-integer linear program to obtain optimal solutions using cutting plane algorithms. We propose a novel upper-bounding algorithm based on the hierarchy of principal minor characterization of positive semi-definite matrices. We further discuss a degree-constrained lower bounding formulation, inspired by robust network structures. In addition, we propose a maximum-cost heuristic with low computational complexity to find high-quality feasible solutions. We show extensive computational results corroborating our proposed methods

    WearPut : Designing Dexterous Wearable Input based on the Characteristics of Human Finger Motions

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    Department of Biomedical Engineering (Human Factors Engineering)Powerful microchips for computing and networking allow a wide range of wearable devices to be miniaturized with high fidelity and availability. In particular, the commercially successful smartwatches placed on the wrist drive market growth by sharing the role of smartphones and health management. The emerging Head Mounted Displays (HMDs) for Augmented Reality (AR) and Virtual Reality (VR) also impact various application areas in video games, education, simulation, and productivity tools. However, these powerful wearables have challenges in interaction with the inevitably limited space for input and output due to the specialized form factors for fitting the body parts. To complement the constrained interaction experience, many wearable devices still rely on other large form factor devices (e.g., smartphones or hand-held controllers). Despite their usefulness, the additional devices for interaction can constrain the viability of wearable devices in many usage scenarios by tethering users' hands to the physical devices. This thesis argues that developing novel Human-Computer interaction techniques for the specialized wearable form factors is vital for wearables to be reliable standalone products. This thesis seeks to address the issue of constrained interaction experience with novel interaction techniques by exploring finger motions during input for the specialized form factors of wearable devices. The several characteristics of the finger input motions are promising to enable increases in the expressiveness of input on the physically limited input space of wearable devices. First, the input techniques with fingers are prevalent on many large form factor devices (e.g., touchscreen or physical keyboard) due to fast and accurate performance and high familiarity. Second, many commercial wearable products provide built-in sensors (e.g., touchscreen or hand tracking system) to detect finger motions. This enables the implementation of novel interaction systems without any additional sensors or devices. Third, the specialized form factors of wearable devices can create unique input contexts while the fingers approach their locations, shapes, and components. Finally, the dexterity of fingers with a distinctive appearance, high degrees of freedom, and high sensitivity of joint angle perception have the potential to widen the range of input available with various movement features on the surface and in the air. Accordingly, the general claim of this thesis is that understanding how users move their fingers during input will enable increases in the expressiveness of the interaction techniques we can create for resource-limited wearable devices. This thesis demonstrates the general claim by providing evidence in various wearable scenarios with smartwatches and HMDs. First, this thesis explored the comfort range of static and dynamic touch input with angles on the touchscreen of smartwatches. The results showed the specific comfort ranges on variations in fingers, finger regions, and poses due to the unique input context that the touching hand approaches a small and fixed touchscreen with a limited range of angles. Then, finger region-aware systems that recognize the flat and side of the finger were constructed based on the contact areas on the touchscreen to enhance the expressiveness of angle-based touch input. In the second scenario, this thesis revealed distinctive touch profiles of different fingers caused by the unique input context for the touchscreen of smartwatches. The results led to the implementation of finger identification systems for distinguishing two or three fingers. Two virtual keyboards with 12 and 16 keys showed the feasibility of touch-based finger identification that enables increases in the expressiveness of touch input techniques. In addition, this thesis supports the general claim with a range of wearable scenarios by exploring the finger input motions in the air. In the third scenario, this thesis investigated the motions of in-air finger stroking during unconstrained in-air typing for HMDs. The results of the observation study revealed details of in-air finger motions during fast sequential input, such as strategies, kinematics, correlated movements, inter-fingerstroke relationship, and individual in-air keys. The in-depth analysis led to a practical guideline for developing robust in-air typing systems with finger stroking. Lastly, this thesis examined the viable locations of in-air thumb touch input to the virtual targets above the palm. It was confirmed that fast and accurate sequential thumb touch can be achieved at a total of 8 key locations with the built-in hand tracking system in a commercial HMD. Final typing studies with a novel in-air thumb typing system verified increases in the expressiveness of virtual target selection on HMDs. This thesis argues that the objective and subjective results and novel interaction techniques in various wearable scenarios support the general claim that understanding how users move their fingers during input will enable increases in the expressiveness of the interaction techniques we can create for resource-limited wearable devices. Finally, this thesis concludes with thesis contributions, design considerations, and the scope of future research works, for future researchers and developers to implement robust finger-based interaction systems on various types of wearable devices.ope

    OpenLB User Guide: Associated with Release 1.6 of the Code

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    OpenLB is an object-oriented implementation of LBM. It is the first implementation of a generic platform for LBM programming, which is shared with the open source community (GPLv2). Since the first release in 2007, the code has been continuously improved and extended which is documented by thirteen releases as well as the corresponding release notes which are available on the OpenLB website (https://www.openlb.net). The OpenLB code is written in C++ and is used by application programmers as well as developers, with the ability to implement custom models OpenLB supports complex data structures that allow simulations in complex geometries and parallel execution using MPI, OpenMP and CUDA on high-performance computers. The source code uses the concepts of interfaces and templates, so that efficient, direct and intuitive implementations of the LBM become possible. The efficiency and scalability has been checked and proved by code reviews. This user manual and a source code documentation by DoxyGen are available on the OpenLB project website

    Middleware control systems design and analysis using message interpreted Petri Nets (MIPN)

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    Many distributed frameworks use a message-oriented middleware to interchange information among several independent distributed modules. Those modules make up complex systems implementing basic actions and reporting events about their state. This paper introduces the Message Interpreted Petri Net (MIPN) model to design, analyze, and execute the central control of these middleware systems. The MIPN is a new Petri net extension that adds message-based high-level information communications and hierarchic capabilities. It also contributes to the definition and study of new properties such as terminability for the hierarchy-wide analysis of a system. Special attention is given to the analyzability of the model. Useful relations between the individual properties of each MIPN and the global properties of a hierarchic MIPNs system are extracted through a mathematical analysis of the model. The goal is to analyze each net separately and then build up the properties of the whole system. This results in a great aid for the programmer and optimizes the development process. This paper also shows the actual integration of this new MIPN model in different robot control frameworks to design, analyze, execute, monitor, log, and debug tasks in such heterogeneous systems. Finally, some applications created with this framework in the fields of robotics, autonomous vehicles, and logistics are also presentedMinisterio de Ciencia e InnovaciĂłn | Ref. EXP00139978CER-2021100

    Ciguatoxins

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    Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies
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